Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01940:Odam'

180854

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Odam

Ensembl Gene

ENSMUSG00000009580

Gene Name

odontogenic, ameloblast asssociated

Synonyms

2310011G06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL01940

Quality Score

Status

Chromosome

Chromosomal Location

88032888-88042033 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 88035192 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Tyrosine at position 52 (S52Y)

Ref Sequence

ENSEMBL: ENSMUSP00000117898 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000113274] [ENSMUST00000129757]

AlphaFold

A1E960

Predicted Effect

possibly damaging
Transcript: ENSMUST00000113274
AA Change: S52Y

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000108899
Gene: ENSMUSG00000009580
AA Change: S52Y

Domain	Start	End	E-Value	Type
Pfam:ODAM	16	273	1.4e-128	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000129757
AA Change: S52Y

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000117898
Gene: ENSMUSG00000009580
AA Change: S52Y

Domain	Start	End	E-Value	Type
Pfam:ODAM	16	273	5.1e-132	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	C	11: 9,517,661 (GRCm39)		probably benign	Het
Ahnak	A	T	19: 8,983,921 (GRCm39)	D1735V	probably benign	Het
Alkbh3	G	A	2: 93,811,940 (GRCm39)	T231I	probably damaging	Het
Ap4e1	T	C	2: 126,885,431 (GRCm39)	V344A	probably damaging	Het
Brip1	T	A	11: 85,955,792 (GRCm39)	D907V	probably benign	Het
Clca3a1	A	T	3: 144,452,737 (GRCm39)	M582K	probably benign	Het
Csf2	G	T	11: 54,140,351 (GRCm39)	P29H	probably damaging	Het
Cyp2d26	C	T	15: 82,676,758 (GRCm39)	R196H	probably benign	Het
Dagla	A	G	19: 10,229,535 (GRCm39)	V575A	probably benign	Het
Dimt1	T	A	13: 107,085,206 (GRCm39)		probably benign	Het
Ei24	A	T	9: 36,693,687 (GRCm39)	F288L	probably damaging	Het
Fam107a	T	C	14: 8,298,766 (GRCm38)	H120R	probably benign	Het
Fancl	G	T	11: 26,409,752 (GRCm39)	V203F	probably damaging	Het
Fgd6	T	A	10: 93,925,512 (GRCm39)		probably null	Het
Flrt2	A	G	12: 95,747,012 (GRCm39)	Y450C	probably damaging	Het
Gm21738	G	A	14: 19,416,979 (GRCm38)	S144L	probably benign	Het
Ift122	A	G	6: 115,864,332 (GRCm39)		probably benign	Het
Kcnk13	A	G	12: 100,027,683 (GRCm39)	S253G	probably benign	Het
Lcp1	A	T	14: 75,453,805 (GRCm39)	N469I	probably benign	Het
Lrrc24	T	C	15: 76,600,257 (GRCm39)	Y294C	probably damaging	Het
Or14j7	C	T	17: 38,235,177 (GRCm39)	T240I	probably damaging	Het
Or4a71	T	A	2: 89,358,154 (GRCm39)	N200I	probably damaging	Het
Or51i2	A	G	7: 103,689,129 (GRCm39)	N42S	probably damaging	Het
Pkd1	G	T	17: 24,798,720 (GRCm39)	R2676L	possibly damaging	Het
Plec	T	C	15: 76,064,529 (GRCm39)	D1915G	probably damaging	Het
Ptbp2	A	G	3: 119,519,764 (GRCm39)	V9A	possibly damaging	Het
Ptk2b	A	G	14: 66,396,062 (GRCm39)	I802T	probably benign	Het
Rabgap1	G	T	2: 37,377,079 (GRCm39)	A304S	probably damaging	Het
Sema3f	T	C	9: 107,560,896 (GRCm39)		probably benign	Het
Serpinb3a	A	T	1: 106,973,915 (GRCm39)	V332E	probably damaging	Het
Skil	T	A	3: 31,165,793 (GRCm39)	M370K	probably benign	Het
Slc25a1	T	A	16: 17,744,304 (GRCm39)	Y209F	probably benign	Het
Smim15	A	G	13: 108,184,164 (GRCm39)	K57E	probably damaging	Het
Taar3	T	A	10: 23,825,855 (GRCm39)	C134S	probably damaging	Het
Tns4	C	T	11: 98,959,047 (GRCm39)	S684N	probably benign	Het
Vmn2r58	A	G	7: 41,487,071 (GRCm39)	V608A	probably benign	Het
Zbtb26	A	T	2: 37,325,987 (GRCm39)	C350S	possibly damaging	Het

Other mutations in Odam

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00970:Odam	APN	5	88,034,467 (GRCm39)	splice site	probably benign
IGL01339:Odam	APN	5	88,033,755 (GRCm39)	critical splice donor site	probably null
IGL02895:Odam	APN	5	88,033,723 (GRCm39)	missense	probably benign	0.32
IGL03051:Odam	APN	5	88,040,335 (GRCm39)	splice site	probably benign
IGL03118:Odam	APN	5	88,033,613 (GRCm39)	missense	unknown
BB005:Odam	UTSW	5	88,035,269 (GRCm39)	missense	possibly damaging	0.95
BB015:Odam	UTSW	5	88,035,269 (GRCm39)	missense	possibly damaging	0.95
R1816:Odam	UTSW	5	88,037,329 (GRCm39)	splice site	probably null
R2033:Odam	UTSW	5	88,040,278 (GRCm39)	missense	probably benign
R4965:Odam	UTSW	5	88,037,967 (GRCm39)	nonsense	probably null
R7257:Odam	UTSW	5	88,035,404 (GRCm39)	missense	probably benign	0.14
R7682:Odam	UTSW	5	88,040,287 (GRCm39)	missense	possibly damaging	0.71
R7928:Odam	UTSW	5	88,035,269 (GRCm39)	missense	possibly damaging	0.95
R8099:Odam	UTSW	5	88,040,299 (GRCm39)	missense	possibly damaging	0.52
R8844:Odam	UTSW	5	88,037,322 (GRCm39)	missense	probably damaging	0.98
R8872:Odam	UTSW	5	88,035,797 (GRCm39)	critical splice acceptor site	probably null
R9006:Odam	UTSW	5	88,040,298 (GRCm39)	missense	probably benign	0.16
R9227:Odam	UTSW	5	88,034,457 (GRCm39)	missense	probably benign	0.32
R9230:Odam	UTSW	5	88,034,457 (GRCm39)	missense	probably benign	0.32
R9705:Odam	UTSW	5	88,037,228 (GRCm39)	missense	probably benign	0.06
R9779:Odam	UTSW	5	88,037,327 (GRCm39)	critical splice donor site	probably null

Posted On

2014-05-07