Incidental Mutation 'IGL01942:Zfp575'
ID180884
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp575
Ensembl Gene ENSMUSG00000066721
Gene Namezinc finger protein 575
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.149) question?
Stock #IGL01942
Quality Score
Status
Chromosome7
Chromosomal Location24583838-24587641 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 24585815 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 134 (T134A)
Ref Sequence ENSEMBL: ENSMUSP00000092294 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077191] [ENSMUST00000094705]
Predicted Effect probably benign
Transcript: ENSMUST00000077191
SMART Domains Protein: ENSMUSP00000076433
Gene: ENSMUSG00000064254

DomainStartEndE-ValueType
Lactamase_B 34 195 1.05e-22 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000094705
AA Change: T134A

PolyPhen 2 Score 0.579 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000092294
Gene: ENSMUSG00000066721
AA Change: T134A

DomainStartEndE-ValueType
ZnF_C2H2 57 79 3.58e-2 SMART
ZnF_C2H2 85 107 4.11e-2 SMART
ZnF_C2H2 113 135 1.14e0 SMART
ZnF_C2H2 141 163 2.71e-2 SMART
ZnF_C2H2 171 193 1.08e-1 SMART
ZnF_C2H2 207 229 8.81e-2 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc6 G A 7: 45,986,573 R1017W possibly damaging Het
Arhgef26 A G 3: 62,340,094 R200G probably benign Het
Arid4b A T 13: 14,136,164 probably benign Het
Atp1a2 A C 1: 172,286,309 S369A probably benign Het
Bag3 T A 7: 128,546,300 D546E probably benign Het
Bcl6b T A 11: 70,226,743 Y379F probably damaging Het
Cbln2 T C 18: 86,716,325 V136A probably benign Het
Ccnf A T 17: 24,242,320 D120E probably benign Het
Cd14 T A 18: 36,725,640 H254L possibly damaging Het
Chd3 A G 11: 69,350,105 probably null Het
Csf2rb G A 15: 78,340,492 R150H probably benign Het
Dhx35 T C 2: 158,831,864 L405P probably damaging Het
Dpf1 G A 7: 29,316,502 C383Y probably damaging Het
Dse T A 10: 34,155,993 Q345L probably benign Het
Gnaz A G 10: 75,014,874 M244V probably damaging Het
Gpr65 A T 12: 98,275,715 Y209F possibly damaging Het
Inpp5f T C 7: 128,667,769 I281T probably damaging Het
Kntc1 T C 5: 123,778,267 F721S probably damaging Het
Mapk8ip2 G A 15: 89,457,017 probably null Het
Med24 G A 11: 98,709,682 R646W probably damaging Het
Nup98 A T 7: 102,194,711 F102Y probably damaging Het
Olfr1260 G T 2: 89,977,978 V67L probably benign Het
Olfr150 A T 9: 39,737,666 M284L possibly damaging Het
Olfr354 A G 2: 36,907,857 M304V probably benign Het
Pgap3 T C 11: 98,397,954 Y125C probably damaging Het
Rasl12 T C 9: 65,408,362 V96A probably damaging Het
Rbm20 G A 19: 53,813,443 M127I probably damaging Het
Rnf114 T A 2: 167,512,626 probably null Het
Serpinb1b C T 13: 33,085,311 T9I possibly damaging Het
Setd1b T A 5: 123,163,426 F16I possibly damaging Het
Slc25a28 A G 19: 43,664,508 F238S probably damaging Het
Slc2a2 T C 3: 28,705,803 V30A probably damaging Het
Slc35f4 T C 14: 49,525,505 probably benign Het
Socs4 T A 14: 47,290,650 C347* probably null Het
Spock1 C T 13: 57,430,328 E367K probably damaging Het
Ubap2 C T 4: 41,251,608 R8H probably benign Het
Vmn1r44 T A 6: 89,893,824 M41K probably benign Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Other mutations in Zfp575
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01293:Zfp575 APN 7 24585757 missense probably damaging 1.00
IGL03136:Zfp575 APN 7 24585956 missense probably damaging 1.00
R0051:Zfp575 UTSW 7 24586087 missense probably benign
R0834:Zfp575 UTSW 7 24585820 missense probably damaging 1.00
R2251:Zfp575 UTSW 7 24585590 missense probably damaging 1.00
R4036:Zfp575 UTSW 7 24586015 missense possibly damaging 0.94
R5416:Zfp575 UTSW 7 24586722 missense probably benign
R5625:Zfp575 UTSW 7 24585652 missense possibly damaging 0.61
R5782:Zfp575 UTSW 7 24585602 missense possibly damaging 0.64
R7599:Zfp575 UTSW 7 24586668 missense probably benign 0.24
Posted On2014-05-07