Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01942:Slc35f4'

180901

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc35f4

Ensembl Gene

ENSMUSG00000021852

Gene Name

solute carrier family 35, member F4

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.151) question?

Stock #

IGL01942

Quality Score

Status

Chromosome

Chromosomal Location

49298519-49526046 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 49525505 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000154089 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074368] [ENSMUST00000123534] [ENSMUST00000138884] [ENSMUST00000146164]

AlphaFold

Q8BZK4

Predicted Effect

probably benign
Transcript: ENSMUST00000074368

SMART Domains

Protein: ENSMUSP00000073972
Gene: ENSMUSG00000021852

Domain	Start	End	E-Value	Type
low complexity region	22	30	N/A	INTRINSIC
transmembrane domain	123	145	N/A	INTRINSIC
transmembrane domain	160	182	N/A	INTRINSIC
Pfam:SLC35F	216	435	7.6e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000123534

SMART Domains

Protein: ENSMUSP00000122405
Gene: ENSMUSG00000021852

Domain	Start	End	E-Value	Type
low complexity region	22	30	N/A	INTRINSIC
transmembrane domain	123	145	N/A	INTRINSIC
transmembrane domain	160	182	N/A	INTRINSIC
transmembrane domain	217	234	N/A	INTRINSIC
transmembrane domain	239	261	N/A	INTRINSIC
transmembrane domain	274	296	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000138884

SMART Domains

Protein: ENSMUSP00000119007
Gene: ENSMUSG00000021852

Domain	Start	End	E-Value	Type
Pfam:EmrE	18	143	1e-12	PFAM
Pfam:EamA	57	135	8.4e-9	PFAM
Pfam:DUF914	68	314	4.8e-8	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000146164

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	G	A	7: 45,986,573	R1017W	possibly damaging	Het
Arhgef26	A	G	3: 62,340,094	R200G	probably benign	Het
Arid4b	A	T	13: 14,136,164		probably benign	Het
Atp1a2	A	C	1: 172,286,309	S369A	probably benign	Het
Bag3	T	A	7: 128,546,300	D546E	probably benign	Het
Bcl6b	T	A	11: 70,226,743	Y379F	probably damaging	Het
Cbln2	T	C	18: 86,716,325	V136A	probably benign	Het
Ccnf	A	T	17: 24,242,320	D120E	probably benign	Het
Cd14	T	A	18: 36,725,640	H254L	possibly damaging	Het
Chd3	A	G	11: 69,350,105		probably null	Het
Csf2rb	G	A	15: 78,340,492	R150H	probably benign	Het
Dhx35	T	C	2: 158,831,864	L405P	probably damaging	Het
Dpf1	G	A	7: 29,316,502	C383Y	probably damaging	Het
Dse	T	A	10: 34,155,993	Q345L	probably benign	Het
Gnaz	A	G	10: 75,014,874	M244V	probably damaging	Het
Gpr65	A	T	12: 98,275,715	Y209F	possibly damaging	Het
Inpp5f	T	C	7: 128,667,769	I281T	probably damaging	Het
Kntc1	T	C	5: 123,778,267	F721S	probably damaging	Het
Mapk8ip2	G	A	15: 89,457,017		probably null	Het
Med24	G	A	11: 98,709,682	R646W	probably damaging	Het
Nup98	A	T	7: 102,194,711	F102Y	probably damaging	Het
Olfr1260	G	T	2: 89,977,978	V67L	probably benign	Het
Olfr150	A	T	9: 39,737,666	M284L	possibly damaging	Het
Olfr354	A	G	2: 36,907,857	M304V	probably benign	Het
Pgap3	T	C	11: 98,397,954	Y125C	probably damaging	Het
Rasl12	T	C	9: 65,408,362	V96A	probably damaging	Het
Rbm20	G	A	19: 53,813,443	M127I	probably damaging	Het
Rnf114	T	A	2: 167,512,626		probably null	Het
Serpinb1b	C	T	13: 33,085,311	T9I	possibly damaging	Het
Setd1b	T	A	5: 123,163,426	F16I	possibly damaging	Het
Slc25a28	A	G	19: 43,664,508	F238S	probably damaging	Het
Slc2a2	T	C	3: 28,705,803	V30A	probably damaging	Het
Socs4	T	A	14: 47,290,650	C347*	probably null	Het
Spock1	C	T	13: 57,430,328	E367K	probably damaging	Het
Ubap2	C	T	4: 41,251,608	R8H	probably benign	Het
Vmn1r44	T	A	6: 89,893,824	M41K	probably benign	Het
Vmn2r-ps159	C	T	4: 156,338,254		noncoding transcript	Het
Zfp575	T	C	7: 24,585,815	T134A	possibly damaging	Het

Other mutations in Slc35f4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01511:Slc35f4	APN	14	49298877	missense	probably benign	0.15
IGL01640:Slc35f4	APN	14	49318768	missense	probably damaging	0.99
IGL01990:Slc35f4	APN	14	49304169	critical splice donor site	probably null
IGL02097:Slc35f4	APN	14	49306246	missense	probably damaging	1.00
IGL02803:Slc35f4	APN	14	49304257	missense	probably benign	0.00
R0005:Slc35f4	UTSW	14	49322486	splice site	probably benign
R0238:Slc35f4	UTSW	14	49304256	missense	possibly damaging	0.78
R0238:Slc35f4	UTSW	14	49304256	missense	possibly damaging	0.78
R0239:Slc35f4	UTSW	14	49304256	missense	possibly damaging	0.78
R0239:Slc35f4	UTSW	14	49304256	missense	possibly damaging	0.78
R0764:Slc35f4	UTSW	14	49306339	splice site	probably benign
R1884:Slc35f4	UTSW	14	49313634	missense	probably damaging	1.00
R1916:Slc35f4	UTSW	14	49303923	intron	probably benign
R2047:Slc35f4	UTSW	14	49303572	intron	probably benign
R2239:Slc35f4	UTSW	14	49306203	critical splice donor site	probably null
R2380:Slc35f4	UTSW	14	49306203	critical splice donor site	probably null
R4273:Slc35f4	UTSW	14	49304301	missense	possibly damaging	0.81
R4420:Slc35f4	UTSW	14	49313577	unclassified	probably benign
R4425:Slc35f4	UTSW	14	49318850	missense	possibly damaging	0.85
R5261:Slc35f4	UTSW	14	49303489	intron	probably benign
R5398:Slc35f4	UTSW	14	49298847	missense	probably damaging	1.00
R5402:Slc35f4	UTSW	14	49318874	missense	probably damaging	1.00
R6310:Slc35f4	UTSW	14	49322457	missense	probably damaging	1.00
R6596:Slc35f4	UTSW	14	49525600	missense	probably damaging	1.00
R6729:Slc35f4	UTSW	14	49318960	missense	probably benign	0.16
R6864:Slc35f4	UTSW	14	49318853	missense	possibly damaging	0.55
R7427:Slc35f4	UTSW	14	49298898	missense	probably damaging	0.99
R7428:Slc35f4	UTSW	14	49298898	missense	probably damaging	0.99
R7559:Slc35f4	UTSW	14	49304275	missense	probably benign	0.03
R7596:Slc35f4	UTSW	14	49306209	missense	probably damaging	1.00
R7722:Slc35f4	UTSW	14	49306274	missense	probably benign	0.22
R8263:Slc35f4	UTSW	14	49313627	missense	probably damaging	1.00
R8525:Slc35f4	UTSW	14	49304224	missense	possibly damaging	0.56
R9198:Slc35f4	UTSW	14	49318920	missense	unknown
R9615:Slc35f4	UTSW	14	49318849	missense	probably benign	0.00
R9751:Slc35f4	UTSW	14	49298834	missense	possibly damaging	0.49
R9772:Slc35f4	UTSW	14	49313718	missense	probably damaging	1.00

Posted On

2014-05-07