Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01946:Ppp1r3g'

180949

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ppp1r3g

Ensembl Gene

ENSMUSG00000050423

Gene Name

protein phosphatase 1, regulatory subunit 3G

Synonyms

1600032L17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL01946

Quality Score

Status

Chromosome

Chromosomal Location

36142822-36154371 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 36152978 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 133 (A133T)

Ref Sequence

ENSEMBL: ENSMUSP00000153702 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000132661] [ENSMUST00000225537]

AlphaFold

Q9CW07

Predicted Effect

possibly damaging
Transcript: ENSMUST00000132661
AA Change: A133T

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000122712
Gene: ENSMUSG00000050423
AA Change: A133T

Domain	Start	End	E-Value	Type
low complexity region	88	102	N/A	INTRINSIC
Pfam:CBM_21	202	339	9.2e-29	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000172766

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000223592

Predicted Effect

possibly damaging
Transcript: ENSMUST00000225537
AA Change: A133T

PolyPhen 2 Score 0.902 (Sensitivity: 0.82; Specificity: 0.94)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	C	T	6: 128,547,442 (GRCm39)	E343K	possibly damaging	Het
Abcc9	T	C	6: 142,571,763 (GRCm39)	I1087V	probably benign	Het
Bcam	A	C	7: 19,494,042 (GRCm39)	Y416*	probably null	Het
Bhlhe22	T	A	3: 18,109,960 (GRCm39)	C337S	probably damaging	Het
Cerkl	T	C	2: 79,223,364 (GRCm39)	D119G	probably benign	Het
Cog6	T	C	3: 52,909,825 (GRCm39)		probably benign	Het
Dchs1	T	C	7: 105,408,312 (GRCm39)	D1840G	probably damaging	Het
Dhx16	G	T	17: 36,196,396 (GRCm39)	M521I	probably benign	Het
Dnaja2	A	G	8: 86,273,329 (GRCm39)	I196T	probably damaging	Het
Fbxw7	T	C	3: 84,811,369 (GRCm39)	Y165H	possibly damaging	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm3371	A	G	14: 44,646,178 (GRCm39)	Y96H	probably damaging	Het
H2-T10	G	A	17: 36,431,608 (GRCm39)	A82V	possibly damaging	Het
Hydin	A	G	8: 111,217,350 (GRCm39)	T1413A	possibly damaging	Het
Krt23	T	A	11: 99,383,665 (GRCm39)	M76L	possibly damaging	Het
Lipe	A	T	7: 25,082,701 (GRCm39)	M504K	possibly damaging	Het
Lrrc37	T	A	11: 103,503,759 (GRCm39)	R560S	probably benign	Het
Lta4h	T	A	10: 93,307,232 (GRCm39)		probably benign	Het
Ltbp2	T	C	12: 84,877,522 (GRCm39)	T348A	probably damaging	Het
Mybpc2	C	A	7: 44,159,322 (GRCm39)		probably benign	Het
Or51r1	T	C	7: 102,227,734 (GRCm39)		probably null	Het
Or52r1b	T	A	7: 102,691,357 (GRCm39)	S219T	probably damaging	Het
Pdp2	G	A	8: 105,320,824 (GRCm39)	M224I	probably benign	Het
Pimreg	C	T	11: 71,935,804 (GRCm39)		probably benign	Het
Pld1	A	T	3: 28,178,766 (GRCm39)	S887C	probably damaging	Het
Prpf8	G	A	11: 75,390,818 (GRCm39)	G1323D	probably damaging	Het
Rab3ip	A	G	10: 116,773,300 (GRCm39)		probably null	Het
Rpain	A	G	11: 70,861,358 (GRCm39)	H9R	possibly damaging	Het
Scin	T	C	12: 40,110,490 (GRCm39)		probably benign	Het
Serpinb6d	A	G	13: 33,855,369 (GRCm39)	T348A	probably benign	Het
Smad3	A	G	9: 63,664,835 (GRCm39)	L42P	probably damaging	Het
Smr3a	C	T	5: 88,156,014 (GRCm39)		probably benign	Het
Vmn2r129	C	T	4: 156,690,549 (GRCm39)		noncoding transcript	Het
Vmn2r13	G	A	5: 109,322,085 (GRCm39)	T204I	probably benign	Het
Zfhx3	A	G	8: 109,660,561 (GRCm39)	N1272D	probably damaging	Het

Other mutations in Ppp1r3g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02890:Ppp1r3g	APN	13	36,153,314 (GRCm39)	missense	probably damaging	0.98
R0413:Ppp1r3g	UTSW	13	36,153,331 (GRCm39)	missense	probably damaging	1.00
R1065:Ppp1r3g	UTSW	13	36,153,418 (GRCm39)	missense	probably benign	0.07
R4497:Ppp1r3g	UTSW	13	36,153,603 (GRCm39)	missense	probably benign	0.15
R5677:Ppp1r3g	UTSW	13	36,153,245 (GRCm39)	missense	probably damaging	1.00
R6705:Ppp1r3g	UTSW	13	36,152,880 (GRCm39)	missense	probably benign	0.08
R8832:Ppp1r3g	UTSW	13	36,153,143 (GRCm39)	nonsense	probably null
R9127:Ppp1r3g	UTSW	13	36,152,621 (GRCm39)	missense	probably benign
R9287:Ppp1r3g	UTSW	13	36,152,834 (GRCm39)	missense	possibly damaging	0.92
R9626:Ppp1r3g	UTSW	13	36,153,612 (GRCm39)	missense	probably benign	0.08
X0027:Ppp1r3g	UTSW	13	36,153,206 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07