Incidental Mutation 'IGL01949:Troap'
ID181011
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Troap
Ensembl Gene ENSMUSG00000032783
Gene Nametrophinin associated protein
SynonymsE130301L11Rik, tastin
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.080) question?
Stock #IGL01949
Quality Score
Status
Chromosome15
Chromosomal Location99074575-99083409 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 99081221 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 341 (S341P)
Ref Sequence ENSEMBL: ENSMUSP00000155404 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039665] [ENSMUST00000064462] [ENSMUST00000230054]
Predicted Effect probably benign
Transcript: ENSMUST00000039665
AA Change: S341P

PolyPhen 2 Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000035389
Gene: ENSMUSG00000032783
AA Change: S341P

DomainStartEndE-ValueType
low complexity region 232 246 N/A INTRINSIC
low complexity region 390 407 N/A INTRINSIC
low complexity region 468 479 N/A INTRINSIC
low complexity region 499 511 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000064462
SMART Domains Protein: ENSMUSP00000068402
Gene: ENSMUSG00000001076

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
C1Q 103 238 2.34e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183449
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229224
Predicted Effect noncoding transcript
Transcript: ENSMUST00000229740
Predicted Effect probably benign
Transcript: ENSMUST00000230054
AA Change: S341P

PolyPhen 2 Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230311
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 C A 15: 94,326,106 R1247L probably benign Het
Atp2a3 T A 11: 72,981,897 M757K probably damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
D430042O09Rik G A 7: 125,761,842 W108* probably null Het
Dusp5 T C 19: 53,537,473 I182T probably damaging Het
Fuca1 T A 4: 135,923,109 probably benign Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21738 G A 14: 19,416,979 S144L probably benign Het
Hap1 G T 11: 100,348,762 D610E probably damaging Het
Hoxa6 T A 6: 52,206,531 Y178F possibly damaging Het
Ighmbp2 A C 19: 3,265,538 D627E probably benign Het
Itgae T C 11: 73,118,184 I497T probably benign Het
Kbtbd3 A G 9: 4,331,066 D480G possibly damaging Het
Kmt2b A T 7: 30,577,161 probably null Het
Krt5 T A 15: 101,710,613 M278L probably benign Het
Krtap4-9 G A 11: 99,785,565 probably benign Het
Myl12a T C 17: 70,996,714 D56G probably benign Het
Olfr117 T C 17: 37,659,466 Y289C probably damaging Het
Pdgfra C A 5: 75,170,665 H310Q probably damaging Het
Pglyrp2 G T 17: 32,416,106 probably null Het
Polk C T 13: 96,483,538 S718N probably benign Het
Ppip5k1 T A 2: 121,337,860 H687L probably benign Het
Pram1 A T 17: 33,641,335 Q292L probably damaging Het
Prodh2 A G 7: 30,509,765 probably null Het
Rgs9 A T 11: 109,259,834 probably null Het
Stk-ps2 A G 1: 46,029,988 noncoding transcript Het
Svep1 C T 4: 58,176,006 G298R probably damaging Het
Ugt3a2 T C 15: 9,335,729 F12S probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp236 G T 18: 82,624,396 T1123K probably damaging Het
Other mutations in Troap
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01140:Troap APN 15 99082146 missense probably damaging 1.00
IGL02468:Troap APN 15 99075361 missense possibly damaging 0.83
IGL02804:Troap APN 15 99077671 splice site probably null
IGL03224:Troap APN 15 99081877 missense probably benign
R0617:Troap UTSW 15 99082660 missense probably damaging 1.00
R1085:Troap UTSW 15 99082163 missense probably damaging 0.99
R1872:Troap UTSW 15 99075352 splice site probably benign
R1884:Troap UTSW 15 99077898 missense probably benign 0.00
R1937:Troap UTSW 15 99077388 missense probably damaging 1.00
R2063:Troap UTSW 15 99082463 missense probably benign 0.00
R2065:Troap UTSW 15 99082463 missense probably benign 0.00
R2066:Troap UTSW 15 99082463 missense probably benign 0.00
R2068:Troap UTSW 15 99082463 missense probably benign 0.00
R2087:Troap UTSW 15 99078817 missense possibly damaging 0.84
R2159:Troap UTSW 15 99077586 missense probably damaging 0.96
R4282:Troap UTSW 15 99078832 missense probably benign
R5296:Troap UTSW 15 99078817 missense probably damaging 0.99
R5557:Troap UTSW 15 99075794 missense possibly damaging 0.92
R5652:Troap UTSW 15 99082264 missense probably benign 0.00
R5764:Troap UTSW 15 99075419 missense probably damaging 1.00
R6891:Troap UTSW 15 99082688 missense possibly damaging 0.56
R8008:Troap UTSW 15 99075630 missense probably benign 0.00
RF012:Troap UTSW 15 99075400 missense probably benign 0.10
Z1177:Troap UTSW 15 99077577 missense probably null
Posted On2014-05-07