Incidental Mutation 'IGL01951:Homez'
ID181037
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Homez
Ensembl Gene ENSMUSG00000057156
Gene Namehomeodomain leucine zipper-encoding gene
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01951
Quality Score
Status
Chromosome14
Chromosomal Location54852736-54870961 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 54858176 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 25 (E25G)
Ref Sequence ENSEMBL: ENSMUSP00000117828 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081162] [ENSMUST00000142283] [ENSMUST00000146642] [ENSMUST00000176259] [ENSMUST00000218311] [ENSMUST00000219350] [ENSMUST00000219519] [ENSMUST00000220122] [ENSMUST00000220208] [ENSMUST00000220403]
Predicted Effect probably damaging
Transcript: ENSMUST00000081162
AA Change: E25G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079929
Gene: ENSMUSG00000057156
AA Change: E25G

DomainStartEndE-ValueType
HOX 37 93 1.7e-1 SMART
low complexity region 244 261 N/A INTRINSIC
HOX 327 388 2.24e-6 SMART
Pfam:Homez 421 477 3.6e-25 PFAM
low complexity region 481 513 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000142283
AA Change: E25G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000117828
Gene: ENSMUSG00000057156
AA Change: E25G

DomainStartEndE-ValueType
HOX 37 93 1.7e-1 SMART
low complexity region 244 261 N/A INTRINSIC
HOX 327 388 2.24e-6 SMART
Pfam:Homez 421 477 7.3e-31 PFAM
low complexity region 481 513 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000146642
AA Change: E25G

PolyPhen 2 Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000114619
Gene: ENSMUSG00000057156
AA Change: E25G

DomainStartEndE-ValueType
HOX 37 93 1.7e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000176259
SMART Domains Protein: ENSMUSP00000135648
Gene: ENSMUSG00000057156

DomainStartEndE-ValueType
Blast:HOX 1 37 7e-20 BLAST
PDB:2ECC|A 1 42 1e-24 PDB
Pfam:Homez 70 126 3.4e-26 PFAM
low complexity region 130 145 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000218311
Predicted Effect probably benign
Transcript: ENSMUST00000219350
Predicted Effect probably benign
Transcript: ENSMUST00000219496
Predicted Effect probably benign
Transcript: ENSMUST00000219519
Predicted Effect probably benign
Transcript: ENSMUST00000220122
Predicted Effect probably benign
Transcript: ENSMUST00000220208
Predicted Effect probably benign
Transcript: ENSMUST00000220403
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik A G 4: 103,235,668 I152T probably damaging Het
A2m C T 6: 121,667,190 T949I possibly damaging Het
Begain T A 12: 109,033,645 Y605F probably benign Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Cavin2 A G 1: 51,289,411 E9G possibly damaging Het
Cdh16 A G 8: 104,617,691 V72A probably damaging Het
Dgkd T C 1: 87,916,916 L268P probably damaging Het
Eps8 T A 6: 137,537,671 Y28F possibly damaging Het
Erap1 T C 13: 74,675,295 I816T probably damaging Het
Fli1 A T 9: 32,461,364 F126Y probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21957 A T 7: 125,219,832 noncoding transcript Het
Gm5862 A C 5: 26,022,771 W41G probably benign Het
Gm9833 G A 3: 10,089,058 V296M probably damaging Het
Hectd1 T A 12: 51,794,497 R618* probably null Het
Ifngr1 C A 10: 19,609,454 N400K possibly damaging Het
Lin7a G A 10: 107,412,025 V186I possibly damaging Het
Lpcat2 G T 8: 92,918,047 S448I probably damaging Het
Lrp10 C A 14: 54,468,662 Y436* probably null Het
Myo1f A G 17: 33,598,017 H707R possibly damaging Het
Neurl4 A G 11: 69,909,623 N1147D probably damaging Het
Olfr1272 G T 2: 90,282,007 D189E probably damaging Het
Olfr1414 T C 1: 92,511,131 D299G probably null Het
Pak6 T C 2: 118,693,260 S299P probably benign Het
Panx2 A G 15: 89,068,767 D487G probably damaging Het
Sbspon T C 1: 15,858,934 N211S probably benign Het
Sgsm1 T A 5: 113,286,767 probably benign Het
Slc38a4 T C 15: 97,019,763 Y27C probably benign Het
Sorbs1 A G 19: 40,318,016 probably benign Het
Ssh1 A T 5: 113,966,247 Y35N possibly damaging Het
Stx2 A T 5: 128,992,265 F127L probably damaging Het
Synm A T 7: 67,739,137 I325N probably damaging Het
Szt2 A G 4: 118,376,493 probably benign Het
Tbc1d23 A G 16: 57,186,685 probably benign Het
Tmem50a T C 4: 134,898,428 probably benign Het
Tpx2 T G 2: 152,884,176 L354V probably benign Het
Trafd1 G A 5: 121,374,031 R399C possibly damaging Het
Trem3 C T 17: 48,249,875 R125W probably damaging Het
Ubp1 T A 9: 113,951,618 Y92* probably null Het
Wnk1 T A 6: 119,963,485 T62S probably damaging Het
Zbtb6 T C 2: 37,429,331 E195G probably benign Het
Zc3h15 A G 2: 83,661,485 D306G probably damaging Het
Other mutations in Homez
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00817:Homez APN 14 54857118 nonsense probably null
IGL01780:Homez APN 14 54857898 missense probably damaging 1.00
IGL02466:Homez APN 14 54858102 missense probably damaging 1.00
R1528:Homez UTSW 14 54857705 missense probably benign 0.13
R1702:Homez UTSW 14 54856995 missense probably damaging 0.99
R1804:Homez UTSW 14 54857141 missense probably damaging 1.00
R2422:Homez UTSW 14 54857574 missense probably benign 0.02
R3121:Homez UTSW 14 54857321 missense probably benign
R4589:Homez UTSW 14 54857030 missense probably damaging 0.99
R4927:Homez UTSW 14 54857807 missense possibly damaging 0.77
R5240:Homez UTSW 14 54858074 missense probably damaging 1.00
R5958:Homez UTSW 14 54856841 missense probably benign 0.17
R7080:Homez UTSW 14 54857655 missense probably benign 0.02
R7256:Homez UTSW 14 54857420 missense probably damaging 1.00
R7815:Homez UTSW 14 54858218 missense probably benign 0.02
R8017:Homez UTSW 14 54858232 missense probably benign 0.00
R8019:Homez UTSW 14 54858232 missense probably benign 0.00
T0975:Homez UTSW 14 54857339 missense possibly damaging 0.85
Posted On2014-05-07