Incidental Mutation 'IGL01951:Lrp10'
ID181048
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrp10
Ensembl Gene ENSMUSG00000022175
Gene Namelow-density lipoprotein receptor-related protein 10
SynonymsLrp9
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01951
Quality Score
Status
Chromosome14
Chromosomal Location54464137-54471497 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 54468662 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Stop codon at position 436 (Y436*)
Ref Sequence ENSEMBL: ENSMUSP00000022782 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022782] [ENSMUST00000227760]
Predicted Effect probably null
Transcript: ENSMUST00000022782
AA Change: Y436*
SMART Domains Protein: ENSMUSP00000022782
Gene: ENSMUSG00000022175
AA Change: Y436*

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
CUB 29 137 5.33e-2 SMART
LDLa 140 177 5.26e-13 SMART
CUB 193 306 2.57e-4 SMART
LDLa 308 356 1.05e-3 SMART
LDLa 357 399 4.89e-2 SMART
LDLa 400 436 1.63e-9 SMART
transmembrane domain 442 464 N/A INTRINSIC
low complexity region 544 569 N/A INTRINSIC
low complexity region 614 629 N/A INTRINSIC
low complexity region 634 655 N/A INTRINSIC
low complexity region 672 681 N/A INTRINSIC
low complexity region 685 710 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226346
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226472
Predicted Effect probably benign
Transcript: ENSMUST00000227760
Predicted Effect probably benign
Transcript: ENSMUST00000228407
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921539E11Rik A G 4: 103,235,668 I152T probably damaging Het
A2m C T 6: 121,667,190 T949I possibly damaging Het
Begain T A 12: 109,033,645 Y605F probably benign Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Cavin2 A G 1: 51,289,411 E9G possibly damaging Het
Cdh16 A G 8: 104,617,691 V72A probably damaging Het
Dgkd T C 1: 87,916,916 L268P probably damaging Het
Eps8 T A 6: 137,537,671 Y28F possibly damaging Het
Erap1 T C 13: 74,675,295 I816T probably damaging Het
Fli1 A T 9: 32,461,364 F126Y probably damaging Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm21957 A T 7: 125,219,832 noncoding transcript Het
Gm5862 A C 5: 26,022,771 W41G probably benign Het
Gm9833 G A 3: 10,089,058 V296M probably damaging Het
Hectd1 T A 12: 51,794,497 R618* probably null Het
Homez T C 14: 54,858,176 E25G probably damaging Het
Ifngr1 C A 10: 19,609,454 N400K possibly damaging Het
Lin7a G A 10: 107,412,025 V186I possibly damaging Het
Lpcat2 G T 8: 92,918,047 S448I probably damaging Het
Myo1f A G 17: 33,598,017 H707R possibly damaging Het
Neurl4 A G 11: 69,909,623 N1147D probably damaging Het
Olfr1272 G T 2: 90,282,007 D189E probably damaging Het
Olfr1414 T C 1: 92,511,131 D299G probably null Het
Pak6 T C 2: 118,693,260 S299P probably benign Het
Panx2 A G 15: 89,068,767 D487G probably damaging Het
Sbspon T C 1: 15,858,934 N211S probably benign Het
Sgsm1 T A 5: 113,286,767 probably benign Het
Slc38a4 T C 15: 97,019,763 Y27C probably benign Het
Sorbs1 A G 19: 40,318,016 probably benign Het
Ssh1 A T 5: 113,966,247 Y35N possibly damaging Het
Stx2 A T 5: 128,992,265 F127L probably damaging Het
Synm A T 7: 67,739,137 I325N probably damaging Het
Szt2 A G 4: 118,376,493 probably benign Het
Tbc1d23 A G 16: 57,186,685 probably benign Het
Tmem50a T C 4: 134,898,428 probably benign Het
Tpx2 T G 2: 152,884,176 L354V probably benign Het
Trafd1 G A 5: 121,374,031 R399C possibly damaging Het
Trem3 C T 17: 48,249,875 R125W probably damaging Het
Ubp1 T A 9: 113,951,618 Y92* probably null Het
Wnk1 T A 6: 119,963,485 T62S probably damaging Het
Zbtb6 T C 2: 37,429,331 E195G probably benign Het
Zc3h15 A G 2: 83,661,485 D306G probably damaging Het
Other mutations in Lrp10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02641:Lrp10 APN 14 54468611 nonsense probably null
IGL02697:Lrp10 APN 14 54469697 missense probably damaging 1.00
IGL02974:Lrp10 APN 14 54467884 nonsense probably null
IGL03030:Lrp10 APN 14 54469162 missense possibly damaging 0.69
chowmein UTSW 14 54468090 missense probably damaging 1.00
egg_fu_young UTSW 14 54469266 missense possibly damaging 0.66
R0452:Lrp10 UTSW 14 54467579 missense probably benign 0.08
R0765:Lrp10 UTSW 14 54468090 missense probably damaging 1.00
R1700:Lrp10 UTSW 14 54469752 missense possibly damaging 0.94
R1726:Lrp10 UTSW 14 54469656 missense probably damaging 0.99
R2943:Lrp10 UTSW 14 54469845 unclassified probably benign
R3746:Lrp10 UTSW 14 54469266 missense possibly damaging 0.66
R3749:Lrp10 UTSW 14 54469266 missense possibly damaging 0.66
R4356:Lrp10 UTSW 14 54468366 missense probably damaging 0.98
R4357:Lrp10 UTSW 14 54468366 missense probably damaging 0.98
R4358:Lrp10 UTSW 14 54468366 missense probably damaging 0.98
R4379:Lrp10 UTSW 14 54468366 missense probably damaging 0.98
R4380:Lrp10 UTSW 14 54468366 missense probably damaging 0.98
R4751:Lrp10 UTSW 14 54468592 missense probably damaging 1.00
R5055:Lrp10 UTSW 14 54468345 missense probably benign 0.00
R5133:Lrp10 UTSW 14 54469610 missense probably benign
R6633:Lrp10 UTSW 14 54469074 missense probably benign 0.03
R6845:Lrp10 UTSW 14 54469688 missense probably damaging 1.00
R6874:Lrp10 UTSW 14 54468213 missense possibly damaging 0.50
R6958:Lrp10 UTSW 14 54469821 unclassified probably benign
R6989:Lrp10 UTSW 14 54468493 missense probably benign 0.30
R7162:Lrp10 UTSW 14 54465706 missense possibly damaging 0.60
R7453:Lrp10 UTSW 14 54468456 missense probably damaging 1.00
R7600:Lrp10 UTSW 14 54469395 missense possibly damaging 0.93
X0026:Lrp10 UTSW 14 54469399 nonsense probably null
X0027:Lrp10 UTSW 14 54468535 missense probably damaging 1.00
Z1088:Lrp10 UTSW 14 54467922 missense probably benign 0.01
Z1177:Lrp10 UTSW 14 54467561 missense possibly damaging 0.75
Posted On2014-05-07