Incidental Mutation 'IGL01952:Olfr736'
ID181072
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr736
Ensembl Gene ENSMUSG00000047716
Gene Nameolfactory receptor 736
SynonymsMOR106-5, GA_x6K02T2PMLR-6089963-6090901
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.152) question?
Stock #IGL01952
Quality Score
Status
Chromosome14
Chromosomal Location50381163-50394192 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 50393403 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 216 (F216I)
Ref Sequence ENSEMBL: ENSMUSP00000149654 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058965] [ENSMUST00000213402] [ENSMUST00000213755] [ENSMUST00000215227] [ENSMUST00000215263]
Predicted Effect probably benign
Transcript: ENSMUST00000058965
AA Change: F216I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000062700
Gene: ENSMUSG00000047716
AA Change: F216I

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 1.5e-45 PFAM
Pfam:7TM_GPCR_Srsx 37 175 6.9e-7 PFAM
Pfam:7tm_1 43 294 4.7e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213402
AA Change: F216I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000213755
AA Change: F216I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000215227
AA Change: F216I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect probably benign
Transcript: ENSMUST00000215263
AA Change: F216I

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Astl T C 2: 127,342,478 probably null Het
Bod1l C T 5: 41,816,954 C2339Y possibly damaging Het
C130026I21Rik A G 1: 85,254,186 probably benign Het
Celsr1 T A 15: 85,963,223 I1438F probably benign Het
Dbr1 T A 9: 99,582,412 N297K possibly damaging Het
Dmxl1 A G 18: 49,890,654 H1668R probably benign Het
Dnajb11 A G 16: 22,865,500 E91G probably damaging Het
Elmsan1 G A 12: 84,173,266 P305S probably benign Het
Gm10717 C T 9: 3,025,616 S67L probably benign Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Grin2d C A 7: 45,862,280 R247L probably benign Het
Gzf1 G A 2: 148,684,061 A151T probably benign Het
Hacl1 C T 14: 31,641,122 probably benign Het
Hivep2 C A 10: 14,142,331 T1854K possibly damaging Het
Htr1d T C 4: 136,443,561 V367A probably benign Het
Ifi208 T C 1: 173,679,031 S127P possibly damaging Het
Ifngr2 C T 16: 91,559,988 P137S probably damaging Het
Lcn9 T C 2: 25,824,538 L138P probably damaging Het
Mdn1 T C 4: 32,723,657 V2531A possibly damaging Het
Meioc A T 11: 102,672,185 I70F possibly damaging Het
Mlph A C 1: 90,933,471 D276A probably benign Het
Myh1 T A 11: 67,220,392 probably null Het
Nlrp9a G A 7: 26,558,019 S265N probably benign Het
Ofcc1 G A 13: 40,280,861 A22V probably damaging Het
Pisd C A 5: 32,739,132 probably null Het
Prlr A G 15: 10,328,342 D301G possibly damaging Het
Ptk2 T C 15: 73,229,931 E810G probably damaging Het
Slco1b2 T G 6: 141,671,230 F430V probably benign Het
Supt6 T C 11: 78,225,760 K646R probably benign Het
Tmem260 C T 14: 48,472,476 A52V probably damaging Het
Tmpo G A 10: 91,163,242 R228C probably benign Het
Tulp1 G A 17: 28,356,424 T103M probably damaging Het
Vwa5b1 G A 4: 138,581,217 P770S probably benign Het
Wdr63 T C 3: 146,097,163 H91R probably damaging Het
Zfp639 A G 3: 32,515,347 Y18C probably damaging Het
Other mutations in Olfr736
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01765:Olfr736 APN 14 50392834 missense probably benign 0.33
IGL01996:Olfr736 APN 14 50393659 missense probably damaging 0.99
IGL02694:Olfr736 APN 14 50392800 missense probably benign 0.02
IGL02717:Olfr736 APN 14 50393647 missense probably damaging 1.00
IGL03185:Olfr736 APN 14 50393398 missense probably damaging 0.99
IGL03218:Olfr736 APN 14 50393658 missense probably damaging 0.98
IGL03048:Olfr736 UTSW 14 50392788 missense possibly damaging 0.47
R0066:Olfr736 UTSW 14 50393202 missense probably benign 0.08
R0066:Olfr736 UTSW 14 50393202 missense probably benign 0.08
R0089:Olfr736 UTSW 14 50392864 missense probably benign
R0254:Olfr736 UTSW 14 50393079 missense probably damaging 0.99
R0284:Olfr736 UTSW 14 50392995 missense probably damaging 1.00
R1800:Olfr736 UTSW 14 50393329 nonsense probably null
R3885:Olfr736 UTSW 14 50392869 missense probably benign 0.05
R4302:Olfr736 UTSW 14 50393446 missense probably benign 0.23
R4452:Olfr736 UTSW 14 50392912 missense probably benign
R4705:Olfr736 UTSW 14 50392800 missense probably benign 0.02
R5340:Olfr736 UTSW 14 50393220 missense probably damaging 0.98
R6007:Olfr736 UTSW 14 50393491 missense probably damaging 1.00
R6338:Olfr736 UTSW 14 50393400 missense possibly damaging 0.47
R6358:Olfr736 UTSW 14 50393388 missense possibly damaging 0.78
R6521:Olfr736 UTSW 14 50393548 missense possibly damaging 0.95
R6527:Olfr736 UTSW 14 50393428 nonsense probably null
R6777:Olfr736 UTSW 14 50393658 missense probably damaging 0.98
R6903:Olfr736 UTSW 14 50393632 missense possibly damaging 0.48
X0026:Olfr736 UTSW 14 50393541 missense possibly damaging 0.79
Posted On2014-05-07