Mutagenetix > Incidental Mutation

Incidental Mutation 'R0058:Tmem207'

18109

Institutional Source

Beutler Lab

Gene Symbol

Tmem207

Ensembl Gene

ENSMUSG00000091972

Gene Name

transmembrane protein 207

Synonyms

LOC224058, 100043057

MMRRC Submission

038352-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R0058 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

26503656-26526769 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 26524829 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000127563 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165687]

AlphaFold

P86045

Predicted Effect

probably benign
Transcript: ENSMUST00000165687

SMART Domains

Protein: ENSMUSP00000127563
Gene: ENSMUSG00000091972

Domain	Start	End	E-Value	Type
Pfam:TMEM52	31	92	4.2e-10	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000231658

Coding Region Coverage

1x: 87.4%
3x: 82.9%
10x: 66.9%
20x: 41.4%

Validation Efficiency

85% (62/73)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	A	G	13: 81,182,672	V6088A	possibly damaging	Het
Ankrd36	A	G	11: 5,630,691		probably benign	Het
Anxa1	A	T	19: 20,383,777	Y84N	probably damaging	Het
Arnt2	G	A	7: 84,347,530	R63C	probably damaging	Het
Avpr1b	A	G	1: 131,599,786	T16A	probably benign	Het
Cables1	A	G	18: 11,923,413	E316G	possibly damaging	Het
Cadm1	A	T	9: 47,850,331	I427L	probably damaging	Het
Dazap1	T	C	10: 80,261,581		probably benign	Het
Dip2b	A	G	15: 100,215,240	E1512G	probably benign	Het
Dock1	G	A	7: 135,108,761	V1171M	possibly damaging	Het
Dock5	A	T	14: 67,781,036	F1230Y	probably benign	Het
Dst	T	C	1: 34,006,224	S13P	possibly damaging	Het
Dym	G	A	18: 75,043,172	E15K	possibly damaging	Het
Faf1	A	G	4: 109,736,624	Q133R	probably benign	Het
Fcer2a	T	C	8: 3,688,111		probably benign	Het
Fmo2	A	T	1: 162,886,324	S204R	probably benign	Het
Ghitm	A	G	14: 37,131,592	L97P	probably damaging	Het
Gins4	A	G	8: 23,229,510		probably benign	Het
Gm10573	G	A	4: 121,920,736			Het
Golga3	T	A	5: 110,202,777	F766Y	possibly damaging	Het
Hapln1	T	C	13: 89,607,878	I267T	probably benign	Het
Helz	A	T	11: 107,672,558		probably benign	Het
Igll1	A	T	16: 16,863,876	V5E	probably benign	Het
Kif16b	A	G	2: 142,857,305		probably null	Het
Limk1	A	T	5: 134,659,871	W507R	probably damaging	Het
Marf1	C	T	16: 14,142,534	A549T	probably damaging	Het
Mtif3	C	A	5: 146,956,921	V159F	probably benign	Het
Ncoa7	T	A	10: 30,647,541	D887V	probably damaging	Het
Pkd1	G	C	17: 24,564,703	A162P	probably benign	Het
Plce1	A	G	19: 38,525,184	D309G	possibly damaging	Het
Plk4	T	C	3: 40,805,872	V401A	probably benign	Het
Prrc2c	C	T	1: 162,698,884	V253I	unknown	Het
Ranbp2	T	A	10: 58,480,531	S2358T	probably damaging	Het
Setd2	T	A	9: 110,594,426	V2183E	probably damaging	Het
Sgsm1	T	A	5: 113,285,087	S232C	probably damaging	Het
Skint6	A	T	4: 113,046,815		probably benign	Het
Slc15a2	A	G	16: 36,754,547	I531T	probably benign	Het
Slc36a1	C	T	11: 55,221,994		probably benign	Het
Sptan1	T	C	2: 29,993,696		probably null	Het
Tex15	C	T	8: 33,581,502		probably benign	Het
Tlr9	T	G	9: 106,224,965	L485R	possibly damaging	Het
Triml2	T	C	8: 43,185,269		probably benign	Het
Tspear	T	C	10: 77,869,631	F288L	probably benign	Het
Zfp644	A	T	5: 106,637,003	S559R	possibly damaging	Het

Other mutations in Tmem207

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01101:Tmem207	APN	16	26517877	nonsense	probably null
IGL02140:Tmem207	APN	16	26516740	missense	probably benign	0.01
IGL02249:Tmem207	APN	16	26517867	missense	possibly damaging	0.86
IGL02394:Tmem207	APN	16	26516836	splice site	probably benign
IGL03380:Tmem207	APN	16	26526657	missense	probably damaging	1.00
R0058:Tmem207	UTSW	16	26524829	splice site	probably benign
R1839:Tmem207	UTSW	16	26524821	missense	possibly damaging	0.80
R4943:Tmem207	UTSW	16	26517853	nonsense	probably null
R7348:Tmem207	UTSW	16	26516827	missense	possibly damaging	0.68
R7947:Tmem207	UTSW	16	26516745	missense	possibly damaging	0.82
R9358:Tmem207	UTSW	16	26526684	missense	probably benign	0.07
R9464:Tmem207	UTSW	16	26526663	missense
R9564:Tmem207	UTSW	16	26516749	nonsense	probably null

Posted On

2013-03-25