Incidental Mutation 'IGL01956:Olfr776'
ID181092
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr776
Ensembl Gene ENSMUSG00000095483
Gene Nameolfactory receptor 776
SynonymsGA_x6K02T2PULF-10947193-10948131, MOR111-12
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL01956
Quality Score
Status
Chromosome10
Chromosomal Location129259127-129264298 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 129261042 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 27 (I27N)
Ref Sequence ENSEMBL: ENSMUSP00000150656 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073704] [ENSMUST00000204573] [ENSMUST00000213512]
Predicted Effect possibly damaging
Transcript: ENSMUST00000073704
AA Change: I27N

PolyPhen 2 Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000073383
Gene: ENSMUSG00000095483
AA Change: I27N

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 8.3e-50 PFAM
Pfam:7tm_1 39 288 3.9e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204573
SMART Domains Protein: ENSMUSP00000145475
Gene: ENSMUSG00000062914

DomainStartEndE-ValueType
Pfam:7tm_4 28 307 1.4e-42 PFAM
Pfam:7tm_1 38 287 1.5e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213512
AA Change: I27N

PolyPhen 2 Score 0.882 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110002H16Rik A G 18: 12,189,350 N620S probably damaging Het
Adamts3 C T 5: 89,677,911 G1022D probably damaging Het
Adgrv1 T C 13: 81,446,430 H4155R possibly damaging Het
Akna A T 4: 63,379,290 D842E probably benign Het
Cacng5 T C 11: 107,882,909 E88G possibly damaging Het
Ccdc36 T C 9: 108,417,319 probably benign Het
Fbxw18 G A 9: 109,693,357 P148L probably damaging Het
Gzf1 G A 2: 148,684,061 A151T probably benign Het
Myo5c A G 9: 75,242,876 probably null Het
Nudcd1 A G 15: 44,400,216 Y277H probably damaging Het
Nvl A G 1: 181,134,944 S154P probably benign Het
Pah G A 10: 87,538,199 E76K probably benign Het
Peli1 T A 11: 21,148,501 I412N probably damaging Het
Slc18a2 T C 19: 59,287,176 probably benign Het
Stx1a T C 5: 135,037,469 probably benign Het
Syne2 G A 12: 76,097,974 D1566N probably damaging Het
Syt7 G T 19: 10,443,391 E433D probably benign Het
Tas2r102 G A 6: 132,762,453 W108* probably null Het
Trappc11 A G 8: 47,528,001 V135A possibly damaging Het
Unk T C 11: 116,056,334 S598P probably damaging Het
Vmn2r-ps159 C T 4: 156,338,254 noncoding transcript Het
Zfp729a A T 13: 67,621,686 H141Q probably damaging Het
Other mutations in Olfr776
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01444:Olfr776 APN 10 129261335 missense probably damaging 1.00
IGL03299:Olfr776 APN 10 129261327 missense probably benign 0.26
IGL03388:Olfr776 APN 10 129261443 missense probably benign 0.00
IGL02802:Olfr776 UTSW 10 129261267 splice site probably null
R1538:Olfr776 UTSW 10 129261213 missense probably damaging 0.99
R3711:Olfr776 UTSW 10 129261224 nonsense probably null
R3712:Olfr776 UTSW 10 129261224 nonsense probably null
R4201:Olfr776 UTSW 10 129261777 missense probably benign 0.19
R4202:Olfr776 UTSW 10 129261777 missense probably benign 0.19
R4726:Olfr776 UTSW 10 129261176 missense possibly damaging 0.84
R5029:Olfr776 UTSW 10 129261838 missense probably benign 0.15
R5623:Olfr776 UTSW 10 129261032 missense probably benign 0.17
R7566:Olfr776 UTSW 10 129261600 missense probably damaging 1.00
R7678:Olfr776 UTSW 10 129261068 missense probably damaging 0.98
Posted On2014-05-07