Incidental Mutation 'IGL01941:Fbxw21'
| ID |
181138 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fbxw21
|
| Ensembl Gene |
ENSMUSG00000047237 |
| Gene Name |
F-box and WD-40 domain protein 21 |
| Synonyms |
E330009P21Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.062)
|
| Stock # |
IGL01941
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
109139447-109162041 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 109148156 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 162
(I162L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000143095
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054925]
[ENSMUST00000198076]
[ENSMUST00000199540]
|
| AlphaFold |
Q8BI38 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054925
AA Change: I162L
PolyPhen 2
Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000056358
Gene: ENSMUSG00000047237
AA Change: I162L
| Domain | Start | End | E-Value | Type |
|---|
|
FBOX
|
5 |
45 |
1.46e-6 |
SMART |
|
SCOP:d1tbga_
|
119 |
249 |
1e-7 |
SMART |
|
Blast:WD40
|
137 |
176 |
1e-6 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197401
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198076
AA Change: I162L
PolyPhen 2
Score 0.067 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000143095
Gene: ENSMUSG00000047237
AA Change: I162L
| Domain | Start | End | E-Value | Type |
|---|
|
FBOX
|
5 |
45 |
1.46e-6 |
SMART |
|
SCOP:d1tbga_
|
119 |
249 |
9e-8 |
SMART |
|
Blast:WD40
|
137 |
176 |
1e-6 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199540
|
| SMART Domains |
Protein: ENSMUSP00000143200
Gene: ENSMUSG00000047237
| Domain | Start | End | E-Value | Type |
|---|
|
FBOX
|
5 |
45 |
9e-9 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9030624G23Rik |
A |
T |
12: 24,044,801 (GRCm38) |
L123Q |
probably benign |
Het |
| Abca2 |
C |
T |
2: 25,443,095 (GRCm38) |
S1602F |
probably benign |
Het |
| Abcc9 |
C |
A |
6: 142,605,904 (GRCm38) |
C1191F |
probably damaging |
Het |
| Adam3 |
G |
T |
8: 24,681,446 (GRCm38) |
|
probably benign |
Het |
| Aldh1l1 |
G |
T |
6: 90,562,695 (GRCm38) |
G202V |
probably damaging |
Het |
| Ankrd46 |
T |
C |
15: 36,485,937 (GRCm38) |
N57D |
possibly damaging |
Het |
| Asic1 |
A |
T |
15: 99,699,101 (GRCm38) |
H548L |
possibly damaging |
Het |
| Atpaf2 |
A |
G |
11: 60,403,898 (GRCm38) |
I233T |
probably benign |
Het |
| Ccdc129 |
A |
G |
6: 55,968,045 (GRCm38) |
R584G |
probably benign |
Het |
| Ccdc185 |
G |
T |
1: 182,748,204 (GRCm38) |
Q307K |
probably benign |
Het |
| Cep120 |
T |
C |
18: 53,723,148 (GRCm38) |
D399G |
probably benign |
Het |
| Cnn2 |
G |
A |
10: 79,992,554 (GRCm38) |
V122M |
probably benign |
Het |
| Dgkd |
T |
C |
1: 87,924,559 (GRCm38) |
S472P |
probably damaging |
Het |
| Dock5 |
A |
C |
14: 67,812,232 (GRCm38) |
I701S |
probably damaging |
Het |
| Efl1 |
A |
G |
7: 82,697,976 (GRCm38) |
E570G |
probably benign |
Het |
| Eln |
G |
A |
5: 134,718,170 (GRCm38) |
|
probably benign |
Het |
| Fat2 |
A |
G |
11: 55,312,005 (GRCm38) |
V81A |
probably benign |
Het |
| Fhl2 |
G |
A |
1: 43,131,672 (GRCm38) |
Q161* |
probably null |
Het |
| Gabrg2 |
A |
G |
11: 41,971,721 (GRCm38) |
Y179H |
probably damaging |
Het |
| Gm10717 |
C |
T |
9: 3,025,616 (GRCm38) |
S67L |
probably benign |
Het |
| Gm10718 |
A |
T |
9: 3,025,118 (GRCm38) |
Y194F |
probably benign |
Het |
| Gm7714 |
A |
G |
5: 88,282,442 (GRCm38) |
S66G |
probably benign |
Het |
| Grik5 |
A |
T |
7: 25,065,182 (GRCm38) |
I152N |
probably damaging |
Het |
| H2-Ab1 |
A |
T |
17: 34,267,434 (GRCm38) |
K156* |
probably null |
Het |
| Hecw1 |
T |
C |
13: 14,316,310 (GRCm38) |
Y699C |
probably benign |
Het |
| Ipo9 |
A |
C |
1: 135,408,073 (GRCm38) |
V202G |
possibly damaging |
Het |
| Jmjd6 |
A |
T |
11: 116,841,358 (GRCm38) |
|
probably null |
Het |
| Lama5 |
A |
G |
2: 180,192,392 (GRCm38) |
I1416T |
possibly damaging |
Het |
| Matn1 |
T |
C |
4: 130,952,261 (GRCm38) |
|
probably benign |
Het |
| Mavs |
T |
C |
2: 131,246,605 (GRCm38) |
V443A |
probably damaging |
Het |
| Mpdz |
A |
T |
4: 81,286,387 (GRCm38) |
S1798R |
possibly damaging |
Het |
| Muc6 |
A |
C |
7: 141,638,584 (GRCm38) |
S2059A |
probably benign |
Het |
| Olfr1251 |
A |
T |
2: 89,667,468 (GRCm38) |
C139* |
probably null |
Het |
| Otud7b |
G |
T |
3: 96,155,459 (GRCm38) |
G672C |
probably benign |
Het |
| Palld |
T |
A |
8: 61,535,700 (GRCm38) |
T572S |
probably benign |
Het |
| Pde6b |
T |
A |
5: 108,423,036 (GRCm38) |
V379E |
probably benign |
Het |
| Peak1 |
A |
G |
9: 56,258,775 (GRCm38) |
V623A |
probably damaging |
Het |
| Prr12 |
C |
T |
7: 45,048,659 (GRCm38) |
|
probably benign |
Het |
| Rxra |
T |
C |
2: 27,754,241 (GRCm38) |
I315T |
probably damaging |
Het |
| Slc11a1 |
C |
T |
1: 74,377,179 (GRCm38) |
A55V |
probably damaging |
Het |
| Slitrk3 |
T |
C |
3: 73,051,071 (GRCm38) |
N123D |
possibly damaging |
Het |
| Spcs1 |
A |
G |
14: 31,000,872 (GRCm38) |
M82T |
probably damaging |
Het |
| Sspo |
A |
G |
6: 48,495,182 (GRCm38) |
E113G |
probably benign |
Het |
| Syne2 |
A |
G |
12: 75,967,220 (GRCm38) |
K3062E |
probably benign |
Het |
| Traf3ip2 |
T |
C |
10: 39,634,660 (GRCm38) |
S310P |
probably benign |
Het |
| Ubp1 |
T |
C |
9: 113,956,758 (GRCm38) |
L167S |
probably damaging |
Het |
| Vmn1r196 |
T |
A |
13: 22,293,699 (GRCm38) |
C169* |
probably null |
Het |
| Vmn1r223 |
T |
A |
13: 23,250,237 (GRCm38) |
F334I |
possibly damaging |
Het |
| Vmn2r10 |
A |
T |
5: 108,995,954 (GRCm38) |
I710N |
probably damaging |
Het |
| Vmn2r-ps159 |
C |
T |
4: 156,338,254 (GRCm38) |
|
noncoding transcript |
Het |
| Wdr26 |
A |
G |
1: 181,211,070 (GRCm38) |
|
probably benign |
Het |
| Wnt7a |
A |
G |
6: 91,394,663 (GRCm38) |
F106L |
probably benign |
Het |
| Zfp940 |
C |
T |
7: 29,846,870 (GRCm38) |
V34M |
probably damaging |
Het |
|
| Other mutations in Fbxw21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00679:Fbxw21
|
APN |
9 |
109,161,964 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00901:Fbxw21
|
APN |
9 |
109,156,399 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01377:Fbxw21
|
APN |
9 |
109,146,645 (GRCm38) |
nonsense |
probably null |
|
|
IGL02491:Fbxw21
|
APN |
9 |
109,143,819 (GRCm38) |
missense |
probably benign |
|
|
IGL03163:Fbxw21
|
APN |
9 |
109,145,484 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL03377:Fbxw21
|
APN |
9 |
109,139,529 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0148:Fbxw21
|
UTSW |
9 |
109,148,017 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0328:Fbxw21
|
UTSW |
9 |
109,146,585 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R0909:Fbxw21
|
UTSW |
9 |
109,156,408 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R1506:Fbxw21
|
UTSW |
9 |
109,148,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1575:Fbxw21
|
UTSW |
9 |
109,161,916 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1615:Fbxw21
|
UTSW |
9 |
109,143,726 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1719:Fbxw21
|
UTSW |
9 |
109,148,174 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R2415:Fbxw21
|
UTSW |
9 |
109,156,401 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R2424:Fbxw21
|
UTSW |
9 |
109,157,519 (GRCm38) |
nonsense |
probably null |
|
|
R2508:Fbxw21
|
UTSW |
9 |
109,145,485 (GRCm38) |
missense |
probably benign |
0.31 |
|
R2898:Fbxw21
|
UTSW |
9 |
109,156,336 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R2964:Fbxw21
|
UTSW |
9 |
109,145,510 (GRCm38) |
missense |
probably benign |
0.10 |
|
R2965:Fbxw21
|
UTSW |
9 |
109,145,510 (GRCm38) |
missense |
probably benign |
0.10 |
|
R2966:Fbxw21
|
UTSW |
9 |
109,145,510 (GRCm38) |
missense |
probably benign |
0.10 |
|
R4809:Fbxw21
|
UTSW |
9 |
109,143,390 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4911:Fbxw21
|
UTSW |
9 |
109,145,663 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5669:Fbxw21
|
UTSW |
9 |
109,145,510 (GRCm38) |
missense |
probably benign |
0.12 |
|
R5928:Fbxw21
|
UTSW |
9 |
109,143,825 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R6043:Fbxw21
|
UTSW |
9 |
109,145,539 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R6277:Fbxw21
|
UTSW |
9 |
109,145,555 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6805:Fbxw21
|
UTSW |
9 |
109,157,565 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6944:Fbxw21
|
UTSW |
9 |
109,157,535 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7079:Fbxw21
|
UTSW |
9 |
109,145,510 (GRCm38) |
missense |
probably benign |
0.10 |
|
R7081:Fbxw21
|
UTSW |
9 |
109,161,922 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7744:Fbxw21
|
UTSW |
9 |
109,157,652 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R7774:Fbxw21
|
UTSW |
9 |
109,143,840 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7980:Fbxw21
|
UTSW |
9 |
109,156,571 (GRCm38) |
splice site |
probably null |
|
|
R8043:Fbxw21
|
UTSW |
9 |
109,146,626 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8260:Fbxw21
|
UTSW |
9 |
109,146,546 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9142:Fbxw21
|
UTSW |
9 |
109,156,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9172:Fbxw21
|
UTSW |
9 |
109,146,696 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9250:Fbxw21
|
UTSW |
9 |
109,143,778 (GRCm38) |
missense |
probably benign |
0.31 |
|
R9251:Fbxw21
|
UTSW |
9 |
109,145,619 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9294:Fbxw21
|
UTSW |
9 |
109,143,762 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9303:Fbxw21
|
UTSW |
9 |
109,157,659 (GRCm38) |
missense |
probably benign |
|
|
R9479:Fbxw21
|
UTSW |
9 |
109,139,544 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9509:Fbxw21
|
UTSW |
9 |
109,148,149 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R9765:Fbxw21
|
UTSW |
9 |
109,146,557 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R9773:Fbxw21
|
UTSW |
9 |
109,148,060 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R9774:Fbxw21
|
UTSW |
9 |
109,161,989 (GRCm38) |
start codon destroyed |
probably null |
0.98 |
|
Z1088:Fbxw21
|
UTSW |
9 |
109,145,537 (GRCm38) |
missense |
probably benign |
|
|
Z1176:Fbxw21
|
UTSW |
9 |
109,145,537 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Fbxw21
|
UTSW |
9 |
109,145,537 (GRCm38) |
missense |
probably benign |
|
|
| Posted On |
2014-05-07 |
Incidental Mutation