Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01950:Vmn2r23'

181286

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL01950

Quality Score

Status

Chromosome

Chromosomal Location

123702821-123742291 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123741886 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 733 (F733L)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000158091

Predicted Effect

possibly damaging
Transcript: ENSMUST00000172391
AA Change: F733L

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: F733L

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adm	G	A	7: 110,628,900 (GRCm38)	R96H	probably damaging	Het
Aebp1	C	T	11: 5,869,108 (GRCm38)	T198I	probably benign	Het
Arhgap8	G	A	15: 84,766,349 (GRCm38)	A237T	probably benign	Het
Arid3b	A	T	9: 57,794,974 (GRCm38)	I500N	probably damaging	Het
Clec1b	T	A	6: 129,400,080 (GRCm38)	W29R	probably damaging	Het
Cyp2e1	T	C	7: 140,764,961 (GRCm38)		probably null	Het
Dnah5	A	G	15: 28,290,289 (GRCm38)	E1275G	probably null	Het
Dnajc13	A	T	9: 104,190,432 (GRCm38)	I1171N	possibly damaging	Het
Dpf3	T	G	12: 83,324,949 (GRCm38)	T171P	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm38)	Y194F	probably benign	Het
Hk1	T	C	10: 62,315,394 (GRCm38)	D57G	probably damaging	Het
Kcnc2	T	G	10: 112,462,075 (GRCm38)		probably benign	Het
Kcnj11	A	T	7: 46,099,149 (GRCm38)	F250Y	probably damaging	Het
Kirrel3	C	T	9: 35,028,329 (GRCm38)		probably benign	Het
Lmbrd1	T	C	1: 24,711,602 (GRCm38)		probably null	Het
Mga	T	C	2: 119,941,654 (GRCm38)	V1665A	possibly damaging	Het
Ms4a3	G	T	19: 11,632,835 (GRCm38)	A121E	probably damaging	Het
Nfix	T	C	8: 84,713,786 (GRCm38)	*392W	probably null	Het
Noxred1	C	T	12: 87,221,416 (GRCm38)	V314M	probably damaging	Het
Or2t47	A	T	11: 58,551,734 (GRCm38)	C168*	probably null	Het
Or51aa5	T	A	7: 103,518,265 (GRCm38)	T40S	probably benign	Het
Phospho1	A	G	11: 95,828,722 (GRCm38)		probably benign	Het
Rev3l	C	T	10: 39,821,157 (GRCm38)	T550M	probably damaging	Het
Sbf2	A	G	7: 110,365,825 (GRCm38)	F955L	probably benign	Het
Slc38a9	C	T	13: 112,695,253 (GRCm38)	T179M	probably damaging	Het
Trpv5	T	G	6: 41,675,978 (GRCm38)	D87A	probably benign	Het
Tubgcp5	A	G	7: 55,806,088 (GRCm38)	Q288R	possibly damaging	Het
Uqcc1	A	G	2: 155,858,138 (GRCm38)	Y172H	probably damaging	Het
Vmn2r71	A	G	7: 85,615,619 (GRCm38)	Y53C	probably damaging	Het
Vwa5a	T	A	9: 38,726,970 (GRCm38)	M263K	probably damaging	Het
Zfp503	C	A	14: 21,986,420 (GRCm38)	A143S	probably benign	Het
Zfp958	T	C	8: 4,628,917 (GRCm38)	L314P	probably damaging	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123,729,725 (GRCm38)	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123,729,596 (GRCm38)	missense	probably benign
IGL01073:Vmn2r23	APN	6	123,712,800 (GRCm38)	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123,704,424 (GRCm38)	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123,704,407 (GRCm38)	missense	probably damaging	1.00
IGL02028:Vmn2r23	APN	6	123,741,860 (GRCm38)	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123,741,744 (GRCm38)	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123,741,836 (GRCm38)	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123,704,478 (GRCm38)	missense	probably benign
IGL02831:Vmn2r23	APN	6	123,704,385 (GRCm38)	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123,704,396 (GRCm38)	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123,741,619 (GRCm38)	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123,741,782 (GRCm38)	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123,704,374 (GRCm38)	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123,729,626 (GRCm38)	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123,712,977 (GRCm38)	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123,729,721 (GRCm38)	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123,713,451 (GRCm38)	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123,742,135 (GRCm38)	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123,742,004 (GRCm38)	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123,713,270 (GRCm38)	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123,713,427 (GRCm38)	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123,729,690 (GRCm38)	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123,702,915 (GRCm38)	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123,713,010 (GRCm38)	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123,741,499 (GRCm38)	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123,704,425 (GRCm38)	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123,742,188 (GRCm38)	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123,713,164 (GRCm38)	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123,713,164 (GRCm38)	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123,713,170 (GRCm38)	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123,741,389 (GRCm38)	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123,729,738 (GRCm38)	missense	probably benign
R4506:Vmn2r23	UTSW	6	123,702,925 (GRCm38)	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123,741,730 (GRCm38)	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123,741,826 (GRCm38)	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123,713,074 (GRCm38)	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123,733,349 (GRCm38)	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123,712,977 (GRCm38)	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123,713,002 (GRCm38)	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123,713,451 (GRCm38)	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123,713,074 (GRCm38)	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123,733,273 (GRCm38)	missense	probably benign
R5761:Vmn2r23	UTSW	6	123,712,759 (GRCm38)	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123,733,393 (GRCm38)	missense	probably damaging	1.00
R5868:Vmn2r23	UTSW	6	123,712,942 (GRCm38)	missense	probably benign	0.12
R5935:Vmn2r23	UTSW	6	123,741,895 (GRCm38)	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123,704,400 (GRCm38)	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123,712,902 (GRCm38)	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123,713,425 (GRCm38)	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123,733,273 (GRCm38)	missense	probably benign
R6925:Vmn2r23	UTSW	6	123,704,553 (GRCm38)	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123,713,022 (GRCm38)	missense	probably benign
R7215:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123,741,581 (GRCm38)	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123,704,579 (GRCm38)	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123,704,541 (GRCm38)	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123,741,353 (GRCm38)	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123,704,640 (GRCm38)	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123,741,656 (GRCm38)	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123,713,472 (GRCm38)	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123,703,032 (GRCm38)	missense
R8966:Vmn2r23	UTSW	6	123,742,120 (GRCm38)	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123,742,079 (GRCm38)	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123,741,823 (GRCm38)	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123,704,364 (GRCm38)	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123,733,393 (GRCm38)	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123,712,713 (GRCm38)	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123,712,713 (GRCm38)	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123,713,116 (GRCm38)	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123,713,161 (GRCm38)	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123,742,108 (GRCm38)	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123,729,725 (GRCm38)	frame shift	probably null

Posted On

2014-05-07