Incidental Mutation 'IGL01953:Lrrc74a'
ID 181349
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lrrc74a
Ensembl Gene ENSMUSG00000059114
Gene Name leucine rich repeat containing 74A
Synonyms Gm6772, Lrrc74
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # IGL01953
Quality Score
Status
Chromosome 12
Chromosomal Location 86781143-86810571 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 86788494 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 158 (L158Q)
Ref Sequence ENSEMBL: ENSMUSP00000152661 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095527] [ENSMUST00000222180] [ENSMUST00000223308]
AlphaFold A0A1Y7VMD6
Predicted Effect probably damaging
Transcript: ENSMUST00000095527
AA Change: L158Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000093183
Gene: ENSMUSG00000059114
AA Change: L158Q

DomainStartEndE-ValueType
Blast:LRR 87 116 9e-7 BLAST
LRR 117 144 4.17e-3 SMART
LRR 145 172 3.16e-3 SMART
LRR 174 201 1.92e-2 SMART
LRR 202 229 3.07e-1 SMART
LRR 230 257 1.03e-2 SMART
LRR 258 285 1.64e-1 SMART
LRR 286 313 2.03e0 SMART
LRR 314 341 1.11e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000222180
Predicted Effect unknown
Transcript: ENSMUST00000223197
AA Change: W44R
Predicted Effect probably damaging
Transcript: ENSMUST00000223308
AA Change: L158Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anks3 G A 16: 4,778,408 (GRCm39) A8V probably damaging Het
Atp6v0a4 A G 6: 38,031,552 (GRCm39) S650P probably damaging Het
B3glct C A 5: 149,669,000 (GRCm39) D311E probably benign Het
Cc2d1a G A 8: 84,870,607 (GRCm39) P119S probably benign Het
Cdcp3 T C 7: 130,826,709 (GRCm39) M261T probably benign Het
Chdh T C 14: 29,757,304 (GRCm39) V409A probably benign Het
Cipc T A 12: 86,999,538 (GRCm39) V4E possibly damaging Het
Dock2 G T 11: 34,623,183 (GRCm39) T70K probably benign Het
Dpf1 T C 7: 29,013,732 (GRCm39) V269A probably damaging Het
Drc7 A T 8: 95,785,753 (GRCm39) Y203F probably damaging Het
Dsg3 C T 18: 20,658,361 (GRCm39) T324I probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Iqcd A T 5: 120,738,554 (GRCm39) N124I probably benign Het
Kdm7a T C 6: 39,123,836 (GRCm39) N776S probably benign Het
Lama5 C T 2: 179,832,497 (GRCm39) R1684H probably damaging Het
Lrp12 A T 15: 39,741,497 (GRCm39) V406D probably damaging Het
Mef2d C T 3: 88,063,813 (GRCm39) T80I probably damaging Het
Megf11 T C 9: 64,597,370 (GRCm39) C681R probably damaging Het
Mex3c A G 18: 73,723,104 (GRCm39) D399G probably damaging Het
Muc20 T C 16: 32,614,073 (GRCm39) T435A probably benign Het
Myo5b T C 18: 74,702,838 (GRCm39) Y10H possibly damaging Het
Or12d13 T C 17: 37,647,766 (GRCm39) D119G probably damaging Het
Or4k40 A G 2: 111,250,657 (GRCm39) L213P probably benign Het
Otoa T A 7: 120,759,548 (GRCm39) probably null Het
P4ha2 T C 11: 54,004,996 (GRCm39) F124S probably benign Het
Phkg2 C T 7: 127,181,512 (GRCm39) P232S probably damaging Het
Piezo1 T A 8: 123,217,923 (GRCm39) Q800L probably damaging Het
Pign C A 1: 105,516,764 (GRCm39) probably benign Het
Pik3r5 A G 11: 68,384,997 (GRCm39) D634G probably benign Het
Ptpn9 A G 9: 56,964,072 (GRCm39) T402A possibly damaging Het
Relb A C 7: 19,349,482 (GRCm39) probably null Het
Scgb1b30 A G 7: 33,799,302 (GRCm39) Q78R probably damaging Het
Sema6a C T 18: 47,423,187 (GRCm39) W273* probably null Het
Sestd1 A G 2: 77,042,813 (GRCm39) V247A possibly damaging Het
Specc1 T A 11: 62,009,122 (GRCm39) S293T probably benign Het
Sptbn2 A G 19: 4,799,721 (GRCm39) D2145G probably benign Het
Trim43b T A 9: 88,967,496 (GRCm39) D380V possibly damaging Het
Vmn1r236 A G 17: 21,507,473 (GRCm39) Y197C possibly damaging Het
Vmn1r79 A G 7: 11,910,382 (GRCm39) Y88C probably damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vmn2r61 G A 7: 41,949,613 (GRCm39) V678M probably damaging Het
Wdfy3 A T 5: 102,042,894 (GRCm39) Y1937* probably null Het
Other mutations in Lrrc74a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Lrrc74a APN 12 86,801,204 (GRCm39) missense probably damaging 1.00
IGL01380:Lrrc74a APN 12 86,808,496 (GRCm39) missense possibly damaging 0.62
IGL01715:Lrrc74a APN 12 86,801,189 (GRCm39) missense probably benign 0.05
IGL01832:Lrrc74a APN 12 86,808,488 (GRCm39) missense probably benign 0.00
IGL02218:Lrrc74a APN 12 86,795,822 (GRCm39) missense probably benign 0.15
IGL02637:Lrrc74a APN 12 86,788,521 (GRCm39) nonsense probably null
IGL03397:Lrrc74a APN 12 86,805,312 (GRCm39) missense probably benign 0.39
R0201:Lrrc74a UTSW 12 86,808,547 (GRCm39) splice site probably benign
R0360:Lrrc74a UTSW 12 86,784,569 (GRCm39) missense probably damaging 1.00
R0403:Lrrc74a UTSW 12 86,787,753 (GRCm39) missense probably damaging 1.00
R0729:Lrrc74a UTSW 12 86,792,353 (GRCm39) nonsense probably null
R1675:Lrrc74a UTSW 12 86,787,800 (GRCm39) missense probably damaging 1.00
R1774:Lrrc74a UTSW 12 86,795,827 (GRCm39) missense probably damaging 1.00
R1818:Lrrc74a UTSW 12 86,784,484 (GRCm39) missense probably damaging 1.00
R4688:Lrrc74a UTSW 12 86,784,472 (GRCm39) nonsense probably null
R6023:Lrrc74a UTSW 12 86,805,380 (GRCm39) missense probably damaging 1.00
R6190:Lrrc74a UTSW 12 86,783,263 (GRCm39) missense probably benign 0.01
R6226:Lrrc74a UTSW 12 86,795,231 (GRCm39) missense possibly damaging 0.87
R6247:Lrrc74a UTSW 12 86,805,330 (GRCm39) missense probably damaging 1.00
R7275:Lrrc74a UTSW 12 86,787,753 (GRCm39) missense probably damaging 1.00
R7631:Lrrc74a UTSW 12 86,795,884 (GRCm39) missense probably damaging 1.00
R7857:Lrrc74a UTSW 12 86,788,485 (GRCm39) missense probably benign 0.00
R8172:Lrrc74a UTSW 12 86,788,530 (GRCm39) missense probably damaging 1.00
R8715:Lrrc74a UTSW 12 86,805,239 (GRCm39) missense probably damaging 1.00
R8717:Lrrc74a UTSW 12 86,783,253 (GRCm39) missense probably damaging 0.99
R9080:Lrrc74a UTSW 12 86,795,908 (GRCm39) missense possibly damaging 0.87
R9612:Lrrc74a UTSW 12 86,805,345 (GRCm39) missense possibly damaging 0.84
X0024:Lrrc74a UTSW 12 86,795,819 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07