Incidental Mutation 'IGL01954:Gpr149'
ID 181381
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr149
Ensembl Gene ENSMUSG00000043441
Gene Name G protein-coupled receptor 149
Synonyms PGR10, 9630018L10Rik, R35, Ieda
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # IGL01954
Quality Score
Status
Chromosome 3
Chromosomal Location 62436851-62512861 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 62438348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 603 (N603S)
Ref Sequence ENSEMBL: ENSMUSP00000060893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058535]
AlphaFold Q3UVY1
Predicted Effect probably benign
Transcript: ENSMUST00000058535
AA Change: N603S

PolyPhen 2 Score 0.364 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000060893
Gene: ENSMUSG00000043441
AA Change: N603S

DomainStartEndE-ValueType
Pfam:7tm_1 52 363 7.2e-7 PFAM
coiled coil region 694 730 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Female mice homozygous for a knock-out allele exhibit increased fertility with increased litter size and frequency. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm4 A T 4: 144,396,741 (GRCm39) D330E probably damaging Het
Acsm3 T C 7: 119,374,306 (GRCm39) probably benign Het
Ankrd26 T A 6: 118,535,966 (GRCm39) Y156F possibly damaging Het
Bcr G A 10: 75,011,173 (GRCm39) probably null Het
Cpn2 C T 16: 30,079,138 (GRCm39) A188T probably benign Het
Ctdsp1 T C 1: 74,433,242 (GRCm39) probably benign Het
Cts7 T A 13: 61,500,637 (GRCm39) R303S probably benign Het
Dock7 T C 4: 98,971,388 (GRCm39) D59G probably damaging Het
Garre1 A T 7: 33,944,460 (GRCm39) W91R probably damaging Het
Gucy2g A G 19: 55,187,123 (GRCm39) I1099T probably benign Het
Gzf1 G A 2: 148,525,981 (GRCm39) A151T probably benign Het
Ighv1-80 A T 12: 115,876,253 (GRCm39) V21D probably benign Het
Klhl18 T C 9: 110,257,934 (GRCm39) Y432C probably damaging Het
Lama4 A G 10: 38,963,295 (GRCm39) D1289G probably benign Het
Mab21l4 T A 1: 93,079,794 (GRCm39) D432V probably damaging Het
Mcm7 T C 5: 138,165,507 (GRCm39) T466A probably damaging Het
Megf8 A G 7: 25,048,439 (GRCm39) E1704G possibly damaging Het
Mettl25 C T 10: 105,659,068 (GRCm39) C405Y probably damaging Het
Muc6 A C 7: 141,218,497 (GRCm39) S2059A probably benign Het
Ndc1 T A 4: 107,253,001 (GRCm39) I590N probably damaging Het
Npnt G T 3: 132,615,724 (GRCm39) N137K probably damaging Het
Numa1 C T 7: 101,645,300 (GRCm39) R309* probably null Het
Ogfod3 G A 11: 121,093,851 (GRCm39) T53I probably benign Het
Or11i1 A G 3: 106,729,311 (GRCm39) I188T possibly damaging Het
Or5v1 C A 17: 37,809,540 (GRCm39) probably benign Het
Pcdhb9 G T 18: 37,534,794 (GRCm39) V263F probably damaging Het
Pld4 T C 12: 112,734,355 (GRCm39) probably null Het
Ppp2r3c A G 12: 55,339,353 (GRCm39) L170P probably damaging Het
Prex2 T A 1: 11,210,235 (GRCm39) D558E possibly damaging Het
Rasal2 A G 1: 157,005,269 (GRCm39) S227P possibly damaging Het
Rasal2 A T 1: 157,003,686 (GRCm39) D324E probably damaging Het
Rcbtb1 A G 14: 59,467,416 (GRCm39) Y418C probably damaging Het
Rhag T C 17: 41,139,341 (GRCm39) F92S possibly damaging Het
Scel T C 14: 103,840,678 (GRCm39) probably benign Het
Serinc5 A G 13: 92,819,441 (GRCm39) N125S probably damaging Het
Sgpl1 A T 10: 60,936,672 (GRCm39) M561K probably benign Het
Sostdc1 T C 12: 36,367,121 (GRCm39) V99A probably damaging Het
Them6 A G 15: 74,593,538 (GRCm39) Y132C probably damaging Het
Vmn2r129 C T 4: 156,690,549 (GRCm39) noncoding transcript Het
Vmn2r27 A T 6: 124,169,207 (GRCm39) F641Y probably damaging Het
Vps13c A G 9: 67,876,580 (GRCm39) Y3384C probably damaging Het
Zbtb32 G T 7: 30,289,353 (GRCm39) probably null Het
Other mutations in Gpr149
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00330:Gpr149 APN 3 62,438,094 (GRCm39) missense probably damaging 1.00
IGL01339:Gpr149 APN 3 62,511,718 (GRCm39) missense probably damaging 1.00
IGL01399:Gpr149 APN 3 62,511,852 (GRCm39) missense probably damaging 1.00
IGL02115:Gpr149 APN 3 62,502,336 (GRCm39) missense probably benign 0.02
IGL02218:Gpr149 APN 3 62,437,952 (GRCm39) utr 3 prime probably benign
IGL02592:Gpr149 APN 3 62,511,231 (GRCm39) missense possibly damaging 0.75
IGL03393:Gpr149 APN 3 62,511,366 (GRCm39) missense probably benign 0.15
R0578:Gpr149 UTSW 3 62,510,110 (GRCm39) missense possibly damaging 0.81
R1173:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1174:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1175:Gpr149 UTSW 3 62,511,888 (GRCm39) missense probably damaging 1.00
R1432:Gpr149 UTSW 3 62,438,439 (GRCm39) missense probably damaging 1.00
R1484:Gpr149 UTSW 3 62,502,592 (GRCm39) missense probably benign 0.00
R1972:Gpr149 UTSW 3 62,438,216 (GRCm39) missense probably benign 0.39
R1973:Gpr149 UTSW 3 62,438,216 (GRCm39) missense probably benign 0.39
R2180:Gpr149 UTSW 3 62,511,489 (GRCm39) missense probably damaging 1.00
R2241:Gpr149 UTSW 3 62,511,474 (GRCm39) missense probably benign 0.00
R3118:Gpr149 UTSW 3 62,502,443 (GRCm39) missense probably benign 0.00
R3547:Gpr149 UTSW 3 62,502,549 (GRCm39) missense probably benign 0.01
R3548:Gpr149 UTSW 3 62,502,549 (GRCm39) missense probably benign 0.01
R4206:Gpr149 UTSW 3 62,511,924 (GRCm39) missense possibly damaging 0.92
R4332:Gpr149 UTSW 3 62,511,794 (GRCm39) missense possibly damaging 0.93
R4531:Gpr149 UTSW 3 62,510,099 (GRCm39) missense probably benign 0.00
R4557:Gpr149 UTSW 3 62,511,918 (GRCm39) missense probably benign 0.02
R4557:Gpr149 UTSW 3 62,438,291 (GRCm39) missense probably damaging 1.00
R4593:Gpr149 UTSW 3 62,510,151 (GRCm39) intron probably benign
R5397:Gpr149 UTSW 3 62,438,226 (GRCm39) missense probably damaging 1.00
R6592:Gpr149 UTSW 3 62,437,961 (GRCm39) missense probably benign 0.02
R6642:Gpr149 UTSW 3 62,437,995 (GRCm39) missense probably damaging 1.00
R6845:Gpr149 UTSW 3 62,511,942 (GRCm39) missense possibly damaging 0.58
R7303:Gpr149 UTSW 3 62,502,491 (GRCm39) missense possibly damaging 0.59
R7659:Gpr149 UTSW 3 62,511,256 (GRCm39) missense probably benign 0.01
R7682:Gpr149 UTSW 3 62,438,160 (GRCm39) missense probably damaging 1.00
R7803:Gpr149 UTSW 3 62,438,136 (GRCm39) missense probably damaging 1.00
R7904:Gpr149 UTSW 3 62,502,356 (GRCm39) missense probably benign 0.00
R7943:Gpr149 UTSW 3 62,438,132 (GRCm39) missense probably damaging 1.00
R8844:Gpr149 UTSW 3 62,502,572 (GRCm39) missense probably benign 0.05
R8919:Gpr149 UTSW 3 62,438,478 (GRCm39) missense probably damaging 1.00
R9043:Gpr149 UTSW 3 62,511,360 (GRCm39) missense probably damaging 1.00
R9209:Gpr149 UTSW 3 62,511,093 (GRCm39) missense probably benign 0.40
Z1177:Gpr149 UTSW 3 62,511,380 (GRCm39) frame shift probably null
Z1190:Gpr149 UTSW 3 62,511,972 (GRCm39) missense possibly damaging 0.95
Posted On 2014-05-07