Incidental Mutation 'IGL01958:Sparcl1'
ID 181442
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sparcl1
Ensembl Gene ENSMUSG00000029309
Gene Name SPARC-like 1
Synonyms hevin, Ecm2, mast9, Sc1
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01958
Quality Score
Status
Chromosome 5
Chromosomal Location 104226977-104261599 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 104240406 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 339 (D339E)
Ref Sequence ENSEMBL: ENSMUSP00000031249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031249] [ENSMUST00000199947]
AlphaFold P70663
Predicted Effect probably benign
Transcript: ENSMUST00000031249
AA Change: D339E

PolyPhen 2 Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000031249
Gene: ENSMUSG00000029309
AA Change: D339E

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 70 81 N/A INTRINSIC
low complexity region 90 101 N/A INTRINSIC
low complexity region 192 210 N/A INTRINSIC
low complexity region 330 340 N/A INTRINSIC
low complexity region 372 381 N/A INTRINSIC
FOLN 418 441 2.33e-5 SMART
KAZAL 441 495 3.62e-11 SMART
Pfam:SPARC_Ca_bdg 498 636 2.8e-44 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000199947
SMART Domains Protein: ENSMUSP00000143177
Gene: ENSMUSG00000029309

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
low complexity region 70 81 N/A INTRINSIC
low complexity region 90 101 N/A INTRINSIC
low complexity region 192 210 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted null mutation exhibit no discernable phenotype; mice are viable and fertile with normal histology and survival. [provided by MGI curators]
Allele List at MGI

All alleles(5) : Targeted(1) Gene trapped(4)

Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4732465J04Rik T C 10: 95,629,659 (GRCm39) I29T probably damaging Het
Agps G A 2: 75,740,045 (GRCm39) probably null Het
Agxt2 A G 15: 10,393,794 (GRCm39) probably null Het
Ahnak T C 19: 8,992,273 (GRCm39) V4519A possibly damaging Het
Aktip T C 8: 91,852,853 (GRCm39) D159G probably damaging Het
Ankrd44 T C 1: 54,806,125 (GRCm39) I94V probably damaging Het
Asph T C 4: 9,474,904 (GRCm39) E674G possibly damaging Het
Atat1 T A 17: 36,219,735 (GRCm39) probably benign Het
Ccar1 G A 10: 62,626,714 (GRCm39) A20V possibly damaging Het
Cdc26 T C 4: 62,321,001 (GRCm39) D14G probably damaging Het
Cdh15 T C 8: 123,586,089 (GRCm39) F156S probably damaging Het
Dctn1 A G 6: 83,168,326 (GRCm39) T525A possibly damaging Het
Dnah8 T G 17: 31,074,869 (GRCm39) probably benign Het
Dnajc10 T A 2: 80,151,648 (GRCm39) probably benign Het
Dtl C A 1: 191,300,489 (GRCm39) W125L probably damaging Het
Fam3c G A 6: 22,318,954 (GRCm39) T149I probably damaging Het
Fgd6 A G 10: 93,974,170 (GRCm39) T1304A probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm6578 A G 6: 12,099,766 (GRCm39) noncoding transcript Het
Gnai1 A G 5: 18,478,568 (GRCm39) F199S probably damaging Het
Grb7 T A 11: 98,345,480 (GRCm39) V480D probably damaging Het
Hdc A G 2: 126,436,452 (GRCm39) L473P possibly damaging Het
Hmcn1 T C 1: 150,479,622 (GRCm39) N4614S probably benign Het
Il20ra A G 10: 19,634,791 (GRCm39) D344G probably benign Het
Ints1 C T 5: 139,745,843 (GRCm39) R1342Q possibly damaging Het
Itga9 T A 9: 118,465,562 (GRCm39) probably benign Het
Kat14 T C 2: 144,236,285 (GRCm39) L339P probably damaging Het
Klhl22 A G 16: 17,594,326 (GRCm39) I152V probably benign Het
Krtap5-2 C A 7: 141,729,459 (GRCm39) G74* probably null Het
Lrrc59 C A 11: 94,529,354 (GRCm39) probably null Het
Map3k13 A G 16: 21,710,873 (GRCm39) Q52R probably benign Het
Mb21d2 A G 16: 28,646,495 (GRCm39) probably benign Het
Mphosph9 A T 5: 124,463,053 (GRCm39) probably benign Het
Myrf A G 19: 10,187,742 (GRCm39) probably benign Het
Nek11 T C 9: 105,177,502 (GRCm39) T250A probably benign Het
Nek5 A T 8: 22,586,842 (GRCm39) V323E probably benign Het
Nfasc A T 1: 132,536,176 (GRCm39) C586* probably null Het
Nup210l T A 3: 90,111,231 (GRCm39) L1711Q possibly damaging Het
Parp8 T G 13: 117,013,108 (GRCm39) K644Q probably benign Het
Pcnt G T 10: 76,269,513 (GRCm39) Q252K probably damaging Het
Pianp A G 6: 124,977,646 (GRCm39) T181A possibly damaging Het
Pkd1 T C 17: 24,799,298 (GRCm39) V2839A probably damaging Het
Poli C T 18: 70,659,657 (GRCm39) R58H possibly damaging Het
Ptk7 T C 17: 46,890,353 (GRCm39) D447G probably benign Het
Rapgef5 A G 12: 117,694,386 (GRCm39) I637V probably benign Het
Rasip1 A T 7: 45,286,188 (GRCm39) R804* probably null Het
Relt A G 7: 100,500,350 (GRCm39) V113A probably benign Het
Rnf215 G T 11: 4,090,317 (GRCm39) C345F probably damaging Het
Scart2 T C 7: 139,854,040 (GRCm39) C348R probably damaging Het
Scn2a A G 2: 65,532,173 (GRCm39) D595G probably damaging Het
Serpina3k G A 12: 104,307,316 (GRCm39) V183M probably damaging Het
Snapc4 T C 2: 26,256,452 (GRCm39) probably benign Het
Tg T C 15: 66,631,335 (GRCm39) F535L probably benign Het
Zbtb45 C A 7: 12,740,203 (GRCm39) A471S probably benign Het
Zfp106 T A 2: 120,365,288 (GRCm39) K373M probably benign Het
Other mutations in Sparcl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00653:Sparcl1 APN 5 104,240,788 (GRCm39) missense probably benign 0.04
IGL01291:Sparcl1 APN 5 104,242,581 (GRCm39) missense possibly damaging 0.88
IGL02749:Sparcl1 APN 5 104,240,746 (GRCm39) missense possibly damaging 0.57
IGL03034:Sparcl1 APN 5 104,241,103 (GRCm39) missense probably damaging 0.96
ANU05:Sparcl1 UTSW 5 104,242,581 (GRCm39) missense possibly damaging 0.88
R0007:Sparcl1 UTSW 5 104,234,946 (GRCm39) missense probably damaging 1.00
R0007:Sparcl1 UTSW 5 104,234,946 (GRCm39) missense probably damaging 1.00
R0071:Sparcl1 UTSW 5 104,233,707 (GRCm39) nonsense probably null
R0071:Sparcl1 UTSW 5 104,233,707 (GRCm39) nonsense probably null
R0278:Sparcl1 UTSW 5 104,236,263 (GRCm39) missense probably benign 0.16
R0360:Sparcl1 UTSW 5 104,237,503 (GRCm39) missense probably damaging 0.99
R0581:Sparcl1 UTSW 5 104,241,178 (GRCm39) missense probably damaging 0.99
R1755:Sparcl1 UTSW 5 104,240,690 (GRCm39) missense probably benign 0.12
R1807:Sparcl1 UTSW 5 104,233,627 (GRCm39) missense probably damaging 1.00
R1925:Sparcl1 UTSW 5 104,241,220 (GRCm39) missense probably benign 0.09
R2110:Sparcl1 UTSW 5 104,236,289 (GRCm39) missense probably damaging 1.00
R2112:Sparcl1 UTSW 5 104,236,289 (GRCm39) missense probably damaging 1.00
R2331:Sparcl1 UTSW 5 104,233,660 (GRCm39) missense probably damaging 1.00
R2567:Sparcl1 UTSW 5 104,232,954 (GRCm39) missense probably damaging 1.00
R3029:Sparcl1 UTSW 5 104,241,092 (GRCm39) missense possibly damaging 0.59
R3104:Sparcl1 UTSW 5 104,241,203 (GRCm39) missense probably benign 0.00
R3106:Sparcl1 UTSW 5 104,241,203 (GRCm39) missense probably benign 0.00
R3979:Sparcl1 UTSW 5 104,240,647 (GRCm39) missense probably benign 0.00
R4772:Sparcl1 UTSW 5 104,236,356 (GRCm39) missense probably benign 0.15
R4967:Sparcl1 UTSW 5 104,240,776 (GRCm39) missense probably damaging 1.00
R5095:Sparcl1 UTSW 5 104,233,629 (GRCm39) missense probably damaging 1.00
R5103:Sparcl1 UTSW 5 104,233,629 (GRCm39) missense probably damaging 1.00
R5105:Sparcl1 UTSW 5 104,233,629 (GRCm39) missense probably damaging 1.00
R5140:Sparcl1 UTSW 5 104,233,629 (GRCm39) missense probably damaging 1.00
R5149:Sparcl1 UTSW 5 104,233,629 (GRCm39) missense probably damaging 1.00
R6245:Sparcl1 UTSW 5 104,233,013 (GRCm39) missense probably damaging 1.00
R6387:Sparcl1 UTSW 5 104,232,926 (GRCm39) missense probably damaging 1.00
R6544:Sparcl1 UTSW 5 104,240,310 (GRCm39) nonsense probably null
R6930:Sparcl1 UTSW 5 104,234,940 (GRCm39) missense probably damaging 1.00
R7246:Sparcl1 UTSW 5 104,233,023 (GRCm39) missense probably benign 0.00
R8490:Sparcl1 UTSW 5 104,233,574 (GRCm39) missense probably null 1.00
R8860:Sparcl1 UTSW 5 104,241,218 (GRCm39) missense probably benign 0.25
R8899:Sparcl1 UTSW 5 104,240,590 (GRCm39) missense probably benign 0.01
R9047:Sparcl1 UTSW 5 104,240,979 (GRCm39) missense possibly damaging 0.90
R9215:Sparcl1 UTSW 5 104,240,701 (GRCm39) missense probably benign 0.05
R9284:Sparcl1 UTSW 5 104,236,345 (GRCm39) nonsense probably null
R9424:Sparcl1 UTSW 5 104,241,030 (GRCm39) missense possibly damaging 0.91
R9622:Sparcl1 UTSW 5 104,234,998 (GRCm39) missense possibly damaging 0.62
Posted On 2014-05-07