Incidental Mutation 'IGL01958:Scart2'
ID 181476
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Scart2
Ensembl Gene ENSMUSG00000054672
Gene Name scavenger receptor family member expressed on T cells 2
Synonyms 5830411N06Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01958
Quality Score
Status
Chromosome 7
Chromosomal Location 139827197-139880649 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 139854040 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 348 (C348R)
Ref Sequence ENSEMBL: ENSMUSP00000131905 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093984] [ENSMUST00000164583]
AlphaFold B3F5L4
Predicted Effect noncoding transcript
Transcript: ENSMUST00000059882
SMART Domains Protein: ENSMUSP00000061346
Gene: ENSMUSG00000054672

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000093984
SMART Domains Protein: ENSMUSP00000091520
Gene: ENSMUSG00000054672

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
SR 238 336 1.65e-34 SMART
SR 340 440 4.53e-32 SMART
SR 446 546 8.78e-30 SMART
SR 551 651 1.26e-53 SMART
SR 656 756 2.88e-16 SMART
SR 783 883 7.62e-48 SMART
transmembrane domain 903 925 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000164583
AA Change: C348R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131905
Gene: ENSMUSG00000054672
AA Change: C348R

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
SR 29 130 1.49e-18 SMART
SR 137 233 2.53e-4 SMART
Blast:SR 291 349 5e-12 BLAST
SR 354 452 1.65e-34 SMART
SR 456 556 4.53e-32 SMART
SR 562 662 8.78e-30 SMART
SR 667 767 1.26e-53 SMART
SR 772 872 2.88e-16 SMART
SR 899 999 7.62e-48 SMART
transmembrane domain 1019 1041 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210212
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4732465J04Rik T C 10: 95,629,659 (GRCm39) I29T probably damaging Het
Agps G A 2: 75,740,045 (GRCm39) probably null Het
Agxt2 A G 15: 10,393,794 (GRCm39) probably null Het
Ahnak T C 19: 8,992,273 (GRCm39) V4519A possibly damaging Het
Aktip T C 8: 91,852,853 (GRCm39) D159G probably damaging Het
Ankrd44 T C 1: 54,806,125 (GRCm39) I94V probably damaging Het
Asph T C 4: 9,474,904 (GRCm39) E674G possibly damaging Het
Atat1 T A 17: 36,219,735 (GRCm39) probably benign Het
Ccar1 G A 10: 62,626,714 (GRCm39) A20V possibly damaging Het
Cdc26 T C 4: 62,321,001 (GRCm39) D14G probably damaging Het
Cdh15 T C 8: 123,586,089 (GRCm39) F156S probably damaging Het
Dctn1 A G 6: 83,168,326 (GRCm39) T525A possibly damaging Het
Dnah8 T G 17: 31,074,869 (GRCm39) probably benign Het
Dnajc10 T A 2: 80,151,648 (GRCm39) probably benign Het
Dtl C A 1: 191,300,489 (GRCm39) W125L probably damaging Het
Fam3c G A 6: 22,318,954 (GRCm39) T149I probably damaging Het
Fgd6 A G 10: 93,974,170 (GRCm39) T1304A probably benign Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm6578 A G 6: 12,099,766 (GRCm39) noncoding transcript Het
Gnai1 A G 5: 18,478,568 (GRCm39) F199S probably damaging Het
Grb7 T A 11: 98,345,480 (GRCm39) V480D probably damaging Het
Hdc A G 2: 126,436,452 (GRCm39) L473P possibly damaging Het
Hmcn1 T C 1: 150,479,622 (GRCm39) N4614S probably benign Het
Il20ra A G 10: 19,634,791 (GRCm39) D344G probably benign Het
Ints1 C T 5: 139,745,843 (GRCm39) R1342Q possibly damaging Het
Itga9 T A 9: 118,465,562 (GRCm39) probably benign Het
Kat14 T C 2: 144,236,285 (GRCm39) L339P probably damaging Het
Klhl22 A G 16: 17,594,326 (GRCm39) I152V probably benign Het
Krtap5-2 C A 7: 141,729,459 (GRCm39) G74* probably null Het
Lrrc59 C A 11: 94,529,354 (GRCm39) probably null Het
Map3k13 A G 16: 21,710,873 (GRCm39) Q52R probably benign Het
Mb21d2 A G 16: 28,646,495 (GRCm39) probably benign Het
Mphosph9 A T 5: 124,463,053 (GRCm39) probably benign Het
Myrf A G 19: 10,187,742 (GRCm39) probably benign Het
Nek11 T C 9: 105,177,502 (GRCm39) T250A probably benign Het
Nek5 A T 8: 22,586,842 (GRCm39) V323E probably benign Het
Nfasc A T 1: 132,536,176 (GRCm39) C586* probably null Het
Nup210l T A 3: 90,111,231 (GRCm39) L1711Q possibly damaging Het
Parp8 T G 13: 117,013,108 (GRCm39) K644Q probably benign Het
Pcnt G T 10: 76,269,513 (GRCm39) Q252K probably damaging Het
Pianp A G 6: 124,977,646 (GRCm39) T181A possibly damaging Het
Pkd1 T C 17: 24,799,298 (GRCm39) V2839A probably damaging Het
Poli C T 18: 70,659,657 (GRCm39) R58H possibly damaging Het
Ptk7 T C 17: 46,890,353 (GRCm39) D447G probably benign Het
Rapgef5 A G 12: 117,694,386 (GRCm39) I637V probably benign Het
Rasip1 A T 7: 45,286,188 (GRCm39) R804* probably null Het
Relt A G 7: 100,500,350 (GRCm39) V113A probably benign Het
Rnf215 G T 11: 4,090,317 (GRCm39) C345F probably damaging Het
Scn2a A G 2: 65,532,173 (GRCm39) D595G probably damaging Het
Serpina3k G A 12: 104,307,316 (GRCm39) V183M probably damaging Het
Snapc4 T C 2: 26,256,452 (GRCm39) probably benign Het
Sparcl1 A T 5: 104,240,406 (GRCm39) D339E probably benign Het
Tg T C 15: 66,631,335 (GRCm39) F535L probably benign Het
Zbtb45 C A 7: 12,740,203 (GRCm39) A471S probably benign Het
Zfp106 T A 2: 120,365,288 (GRCm39) K373M probably benign Het
Other mutations in Scart2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Scart2 APN 7 139,874,755 (GRCm39) missense probably damaging 0.99
IGL01101:Scart2 APN 7 139,876,017 (GRCm39) missense probably benign 0.35
IGL01120:Scart2 APN 7 139,876,472 (GRCm39) missense probably benign 0.02
IGL02150:Scart2 APN 7 139,877,772 (GRCm39) missense possibly damaging 0.84
IGL02193:Scart2 APN 7 139,828,913 (GRCm39) missense probably benign 0.17
IGL02239:Scart2 APN 7 139,875,756 (GRCm39) missense probably damaging 1.00
IGL02335:Scart2 APN 7 139,876,453 (GRCm39) missense probably damaging 1.00
IGL02569:Scart2 APN 7 139,878,275 (GRCm39) missense probably benign 0.01
IGL02993:Scart2 APN 7 139,876,486 (GRCm39) missense probably benign 0.07
IGL03261:Scart2 APN 7 139,874,746 (GRCm39) missense probably benign 0.00
IGL03365:Scart2 APN 7 139,876,682 (GRCm39) missense probably damaging 1.00
IGL03399:Scart2 APN 7 139,827,869 (GRCm39) missense probably benign 0.00
IGL03052:Scart2 UTSW 7 139,828,827 (GRCm39) missense probably damaging 1.00
PIT4791001:Scart2 UTSW 7 139,853,975 (GRCm39) missense possibly damaging 0.53
R0021:Scart2 UTSW 7 139,876,310 (GRCm39) missense probably benign 0.15
R0021:Scart2 UTSW 7 139,876,310 (GRCm39) missense probably benign 0.15
R0347:Scart2 UTSW 7 139,877,767 (GRCm39) missense probably damaging 1.00
R0374:Scart2 UTSW 7 139,828,874 (GRCm39) missense probably damaging 1.00
R0639:Scart2 UTSW 7 139,827,872 (GRCm39) missense probably benign 0.01
R0667:Scart2 UTSW 7 139,841,450 (GRCm39) missense possibly damaging 0.73
R0789:Scart2 UTSW 7 139,828,133 (GRCm39) missense probably damaging 1.00
R0959:Scart2 UTSW 7 139,874,704 (GRCm39) missense probably damaging 1.00
R1316:Scart2 UTSW 7 139,879,583 (GRCm39) missense probably benign 0.09
R1764:Scart2 UTSW 7 139,877,178 (GRCm39) missense probably benign 0.00
R2247:Scart2 UTSW 7 139,829,042 (GRCm39) missense probably null 0.96
R2379:Scart2 UTSW 7 139,879,682 (GRCm39) missense probably benign 0.15
R4112:Scart2 UTSW 7 139,878,281 (GRCm39) nonsense probably null
R4114:Scart2 UTSW 7 139,877,823 (GRCm39) missense probably damaging 1.00
R4346:Scart2 UTSW 7 139,827,878 (GRCm39) missense probably damaging 0.97
R4836:Scart2 UTSW 7 139,879,021 (GRCm39) missense probably benign
R4956:Scart2 UTSW 7 139,878,275 (GRCm39) missense probably benign 0.00
R5208:Scart2 UTSW 7 139,877,949 (GRCm39) missense probably benign 0.00
R5571:Scart2 UTSW 7 139,829,036 (GRCm39) missense probably damaging 1.00
R5583:Scart2 UTSW 7 139,876,739 (GRCm39) missense probably damaging 1.00
R5645:Scart2 UTSW 7 139,828,853 (GRCm39) missense possibly damaging 0.95
R6183:Scart2 UTSW 7 139,875,947 (GRCm39) missense possibly damaging 0.82
R6995:Scart2 UTSW 7 139,841,514 (GRCm39) missense probably benign
R7436:Scart2 UTSW 7 139,841,520 (GRCm39) missense probably benign
R7621:Scart2 UTSW 7 139,876,742 (GRCm39) missense probably damaging 1.00
R7662:Scart2 UTSW 7 139,874,725 (GRCm39) missense possibly damaging 0.58
R7669:Scart2 UTSW 7 139,876,234 (GRCm39) missense possibly damaging 0.47
R7686:Scart2 UTSW 7 139,828,965 (GRCm39) missense probably benign 0.00
R7985:Scart2 UTSW 7 139,876,806 (GRCm39) missense probably damaging 1.00
R8330:Scart2 UTSW 7 139,876,231 (GRCm39) nonsense probably null
R8843:Scart2 UTSW 7 139,828,913 (GRCm39) missense possibly damaging 0.93
R8888:Scart2 UTSW 7 139,841,532 (GRCm39) missense possibly damaging 0.93
R8895:Scart2 UTSW 7 139,841,532 (GRCm39) missense possibly damaging 0.93
R9044:Scart2 UTSW 7 139,828,010 (GRCm39) missense probably damaging 1.00
R9142:Scart2 UTSW 7 139,877,806 (GRCm39) missense probably damaging 1.00
R9152:Scart2 UTSW 7 139,877,256 (GRCm39) missense possibly damaging 0.55
R9470:Scart2 UTSW 7 139,827,345 (GRCm39) missense probably benign 0.07
R9509:Scart2 UTSW 7 139,879,644 (GRCm39) nonsense probably null
R9522:Scart2 UTSW 7 139,853,987 (GRCm39) missense possibly damaging 0.73
R9755:Scart2 UTSW 7 139,841,544 (GRCm39) critical splice donor site probably null
R9794:Scart2 UTSW 7 139,874,716 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07