Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01958:Lrrc59'

181485

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc59

Ensembl Gene

ENSMUSG00000020869

Gene Name

leucine rich repeat containing 59

Synonyms

C78668

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.277) question?

Stock #

IGL01958

Quality Score

Status

Chromosome

Chromosomal Location

94520603-94536049 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to A at 94529354 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000021239 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021239]

AlphaFold

Q922Q8

Predicted Effect

probably null
Transcript: ENSMUST00000021239

SMART Domains

Protein: ENSMUSP00000021239
Gene: ENSMUSG00000020869

Domain	Start	End	E-Value	Type
LRR	38	60	6.22e0	SMART
LRR	61	83	1.33e-1	SMART
LRR	84	106	3.75e0	SMART
LRR	107	131	1.09e2	SMART
coiled coil region	148	216	N/A	INTRINSIC
transmembrane domain	244	266	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138782

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4732465J04Rik	T	C	10: 95,629,659 (GRCm39)	I29T	probably damaging	Het
Agps	G	A	2: 75,740,045 (GRCm39)		probably null	Het
Agxt2	A	G	15: 10,393,794 (GRCm39)		probably null	Het
Ahnak	T	C	19: 8,992,273 (GRCm39)	V4519A	possibly damaging	Het
Aktip	T	C	8: 91,852,853 (GRCm39)	D159G	probably damaging	Het
Ankrd44	T	C	1: 54,806,125 (GRCm39)	I94V	probably damaging	Het
Asph	T	C	4: 9,474,904 (GRCm39)	E674G	possibly damaging	Het
Atat1	T	A	17: 36,219,735 (GRCm39)		probably benign	Het
Ccar1	G	A	10: 62,626,714 (GRCm39)	A20V	possibly damaging	Het
Cdc26	T	C	4: 62,321,001 (GRCm39)	D14G	probably damaging	Het
Cdh15	T	C	8: 123,586,089 (GRCm39)	F156S	probably damaging	Het
Dctn1	A	G	6: 83,168,326 (GRCm39)	T525A	possibly damaging	Het
Dnah8	T	G	17: 31,074,869 (GRCm39)		probably benign	Het
Dnajc10	T	A	2: 80,151,648 (GRCm39)		probably benign	Het
Dtl	C	A	1: 191,300,489 (GRCm39)	W125L	probably damaging	Het
Fam3c	G	A	6: 22,318,954 (GRCm39)	T149I	probably damaging	Het
Fgd6	A	G	10: 93,974,170 (GRCm39)	T1304A	probably benign	Het
Gm10718	A	T	9: 3,025,118 (GRCm39)	Y194F	probably benign	Het
Gm6578	A	G	6: 12,099,766 (GRCm39)		noncoding transcript	Het
Gnai1	A	G	5: 18,478,568 (GRCm39)	F199S	probably damaging	Het
Grb7	T	A	11: 98,345,480 (GRCm39)	V480D	probably damaging	Het
Hdc	A	G	2: 126,436,452 (GRCm39)	L473P	possibly damaging	Het
Hmcn1	T	C	1: 150,479,622 (GRCm39)	N4614S	probably benign	Het
Il20ra	A	G	10: 19,634,791 (GRCm39)	D344G	probably benign	Het
Ints1	C	T	5: 139,745,843 (GRCm39)	R1342Q	possibly damaging	Het
Itga9	T	A	9: 118,465,562 (GRCm39)		probably benign	Het
Kat14	T	C	2: 144,236,285 (GRCm39)	L339P	probably damaging	Het
Klhl22	A	G	16: 17,594,326 (GRCm39)	I152V	probably benign	Het
Krtap5-2	C	A	7: 141,729,459 (GRCm39)	G74*	probably null	Het
Map3k13	A	G	16: 21,710,873 (GRCm39)	Q52R	probably benign	Het
Mb21d2	A	G	16: 28,646,495 (GRCm39)		probably benign	Het
Mphosph9	A	T	5: 124,463,053 (GRCm39)		probably benign	Het
Myrf	A	G	19: 10,187,742 (GRCm39)		probably benign	Het
Nek11	T	C	9: 105,177,502 (GRCm39)	T250A	probably benign	Het
Nek5	A	T	8: 22,586,842 (GRCm39)	V323E	probably benign	Het
Nfasc	A	T	1: 132,536,176 (GRCm39)	C586*	probably null	Het
Nup210l	T	A	3: 90,111,231 (GRCm39)	L1711Q	possibly damaging	Het
Parp8	T	G	13: 117,013,108 (GRCm39)	K644Q	probably benign	Het
Pcnt	G	T	10: 76,269,513 (GRCm39)	Q252K	probably damaging	Het
Pianp	A	G	6: 124,977,646 (GRCm39)	T181A	possibly damaging	Het
Pkd1	T	C	17: 24,799,298 (GRCm39)	V2839A	probably damaging	Het
Poli	C	T	18: 70,659,657 (GRCm39)	R58H	possibly damaging	Het
Ptk7	T	C	17: 46,890,353 (GRCm39)	D447G	probably benign	Het
Rapgef5	A	G	12: 117,694,386 (GRCm39)	I637V	probably benign	Het
Rasip1	A	T	7: 45,286,188 (GRCm39)	R804*	probably null	Het
Relt	A	G	7: 100,500,350 (GRCm39)	V113A	probably benign	Het
Rnf215	G	T	11: 4,090,317 (GRCm39)	C345F	probably damaging	Het
Scart2	T	C	7: 139,854,040 (GRCm39)	C348R	probably damaging	Het
Scn2a	A	G	2: 65,532,173 (GRCm39)	D595G	probably damaging	Het
Serpina3k	G	A	12: 104,307,316 (GRCm39)	V183M	probably damaging	Het
Snapc4	T	C	2: 26,256,452 (GRCm39)		probably benign	Het
Sparcl1	A	T	5: 104,240,406 (GRCm39)	D339E	probably benign	Het
Tg	T	C	15: 66,631,335 (GRCm39)	F535L	probably benign	Het
Zbtb45	C	A	7: 12,740,203 (GRCm39)	A471S	probably benign	Het
Zfp106	T	A	2: 120,365,288 (GRCm39)	K373M	probably benign	Het

Other mutations in Lrrc59

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01321:Lrrc59	APN	11	94,529,426 (GRCm39)	nonsense	probably null
IGL01525:Lrrc59	APN	11	94,525,522 (GRCm39)	missense	probably damaging	0.99
IGL01929:Lrrc59	APN	11	94,534,342 (GRCm39)	missense	possibly damaging	0.69
IGL02635:Lrrc59	APN	11	94,534,282 (GRCm39)	missense	probably damaging	1.00
R0277:Lrrc59	UTSW	11	94,534,248 (GRCm39)	missense	probably damaging	1.00
R0323:Lrrc59	UTSW	11	94,534,248 (GRCm39)	missense	probably damaging	1.00
R1794:Lrrc59	UTSW	11	94,529,421 (GRCm39)	missense	probably benign
R4833:Lrrc59	UTSW	11	94,525,498 (GRCm39)	missense	probably benign	0.00
R6242:Lrrc59	UTSW	11	94,525,809 (GRCm39)	missense	possibly damaging	0.65
R6817:Lrrc59	UTSW	11	94,520,891 (GRCm39)	missense	probably damaging	1.00
R7709:Lrrc59	UTSW	11	94,525,811 (GRCm39)	missense	probably damaging	1.00
R7724:Lrrc59	UTSW	11	94,534,170 (GRCm39)	missense	probably damaging	0.99
R8066:Lrrc59	UTSW	11	94,525,426 (GRCm39)	missense	possibly damaging	0.88
R9143:Lrrc59	UTSW	11	94,525,456 (GRCm39)	missense	probably damaging	1.00
R9166:Lrrc59	UTSW	11	94,522,959 (GRCm39)	missense	probably benign	0.00
R9266:Lrrc59	UTSW	11	94,532,044 (GRCm39)	critical splice acceptor site	probably null
Z1176:Lrrc59	UTSW	11	94,534,147 (GRCm39)	missense	probably benign	0.19

Posted On

2014-05-07