Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01958:Lrrc59'

181485

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc59

Ensembl Gene

ENSMUSG00000020869

Gene Name

leucine rich repeat containing 59

Synonyms

C78668

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.283) question?

Stock #

IGL01958

Quality Score

Status

Chromosome

Chromosomal Location

94629767-94645216 bp(+) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

C to A at 94638528 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000021239 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021239]

AlphaFold

Q922Q8

Predicted Effect

probably null
Transcript: ENSMUST00000021239

SMART Domains

Protein: ENSMUSP00000021239
Gene: ENSMUSG00000020869

Domain	Start	End	E-Value	Type
LRR	38	60	6.22e0	SMART
LRR	61	83	1.33e-1	SMART
LRR	84	106	3.75e0	SMART
LRR	107	131	1.09e2	SMART
coiled coil region	148	216	N/A	INTRINSIC
transmembrane domain	244	266	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138782

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4732465J04Rik	T	C	10: 95,793,797	I29T	probably damaging	Het
5830411N06Rik	T	C	7: 140,274,127	C348R	probably damaging	Het
Agps	G	A	2: 75,909,701		probably null	Het
Agxt2	A	G	15: 10,393,708		probably null	Het
Ahnak	T	C	19: 9,014,909	V4519A	possibly damaging	Het
Aktip	T	C	8: 91,126,225	D159G	probably damaging	Het
Ankrd44	T	C	1: 54,766,966	I94V	probably damaging	Het
Asph	T	C	4: 9,474,904	E674G	possibly damaging	Het
Atat1	T	A	17: 35,908,843		probably benign	Het
Ccar1	G	A	10: 62,790,935	A20V	possibly damaging	Het
Cdc26	T	C	4: 62,402,764	D14G	probably damaging	Het
Cdh15	T	C	8: 122,859,350	F156S	probably damaging	Het
Dctn1	A	G	6: 83,191,344	T525A	possibly damaging	Het
Dnah8	T	G	17: 30,855,895		probably benign	Het
Dnajc10	T	A	2: 80,321,304		probably benign	Het
Dtl	C	A	1: 191,568,377	W125L	probably damaging	Het
Fam3c	G	A	6: 22,318,955	T149I	probably damaging	Het
Fgd6	A	G	10: 94,138,308	T1304A	probably benign	Het
Gm10718	A	T	9: 3,025,118	Y194F	probably benign	Het
Gm6578	A	G	6: 12,099,767		noncoding transcript	Het
Gnai1	A	G	5: 18,273,570	F199S	probably damaging	Het
Grb7	T	A	11: 98,454,654	V480D	probably damaging	Het
Hdc	A	G	2: 126,594,532	L473P	possibly damaging	Het
Hmcn1	T	C	1: 150,603,871	N4614S	probably benign	Het
Il20ra	A	G	10: 19,759,043	D344G	probably benign	Het
Ints1	C	T	5: 139,760,088	R1342Q	possibly damaging	Het
Itga9	T	A	9: 118,636,494		probably benign	Het
Kat14	T	C	2: 144,394,365	L339P	probably damaging	Het
Klhl22	A	G	16: 17,776,462	I152V	probably benign	Het
Krtap5-2	C	A	7: 142,175,722	G74*	probably null	Het
Map3k13	A	G	16: 21,892,123	Q52R	probably benign	Het
Mb21d2	A	G	16: 28,827,743		probably benign	Het
Mphosph9	A	T	5: 124,324,990		probably benign	Het
Myrf	A	G	19: 10,210,378		probably benign	Het
Nek11	T	C	9: 105,300,303	T250A	probably benign	Het
Nek5	A	T	8: 22,096,826	V323E	probably benign	Het
Nfasc	A	T	1: 132,608,438	C586*	probably null	Het
Nup210l	T	A	3: 90,203,924	L1711Q	possibly damaging	Het
Parp8	T	G	13: 116,876,572	K644Q	probably benign	Het
Pcnt	G	T	10: 76,433,679	Q252K	probably damaging	Het
Pianp	A	G	6: 125,000,683	T181A	possibly damaging	Het
Pkd1	T	C	17: 24,580,324	V2839A	probably damaging	Het
Poli	C	T	18: 70,526,586	R58H	possibly damaging	Het
Ptk7	T	C	17: 46,579,427	D447G	probably benign	Het
Rapgef5	A	G	12: 117,730,651	I637V	probably benign	Het
Rasip1	A	T	7: 45,636,764	R804*	probably null	Het
Relt	A	G	7: 100,851,143	V113A	probably benign	Het
Rnf215	G	T	11: 4,140,317	C345F	probably damaging	Het
Scn2a	A	G	2: 65,701,829	D595G	probably damaging	Het
Serpina3k	G	A	12: 104,341,057	V183M	probably damaging	Het
Snapc4	T	C	2: 26,366,440		probably benign	Het
Sparcl1	A	T	5: 104,092,540	D339E	probably benign	Het
Tg	T	C	15: 66,759,486	F535L	probably benign	Het
Zbtb45	C	A	7: 13,006,276	A471S	probably benign	Het
Zfp106	T	A	2: 120,534,807	K373M	probably benign	Het

Other mutations in Lrrc59

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01321:Lrrc59	APN	11	94638600	nonsense	probably null
IGL01525:Lrrc59	APN	11	94634696	missense	probably damaging	0.99
IGL01929:Lrrc59	APN	11	94643516	missense	possibly damaging	0.69
IGL02635:Lrrc59	APN	11	94643456	missense	probably damaging	1.00
R0277:Lrrc59	UTSW	11	94643422	missense	probably damaging	1.00
R0323:Lrrc59	UTSW	11	94643422	missense	probably damaging	1.00
R1794:Lrrc59	UTSW	11	94638595	missense	probably benign
R4833:Lrrc59	UTSW	11	94634672	missense	probably benign	0.00
R6242:Lrrc59	UTSW	11	94634983	missense	possibly damaging	0.65
R6817:Lrrc59	UTSW	11	94630065	missense	probably damaging	1.00
R7709:Lrrc59	UTSW	11	94634985	missense	probably damaging	1.00
R7724:Lrrc59	UTSW	11	94643344	missense	probably damaging	0.99
R8066:Lrrc59	UTSW	11	94634600	missense	possibly damaging	0.88
R9143:Lrrc59	UTSW	11	94634630	missense	probably damaging	1.00
R9166:Lrrc59	UTSW	11	94632133	missense	probably benign	0.00
R9266:Lrrc59	UTSW	11	94641218	critical splice acceptor site	probably null
Z1176:Lrrc59	UTSW	11	94643321	missense	probably benign	0.19

Posted On

2014-05-07