Incidental Mutation 'IGL01966:Olfr904'
ID 181543
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr904
Ensembl Gene ENSMUSG00000094380
Gene Name olfactory receptor 904
Synonyms GA_x6K02T2PVTD-32156773-32157705, MOR167-3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # IGL01966
Quality Score
Chromosome 9
Chromosomal Location 38463144-38468995 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38464929 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 296 (D296V)
Ref Sequence ENSEMBL: ENSMUSP00000150057 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058153] [ENSMUST00000216724]
AlphaFold Q7TRC9
Predicted Effect possibly damaging
Transcript: ENSMUST00000058153
AA Change: D296V

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000057148
Gene: ENSMUSG00000094380
AA Change: D296V

Pfam:7tm_4 31 308 5.7e-51 PFAM
Pfam:7tm_1 41 291 1.5e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216724
AA Change: D296V

PolyPhen 2 Score 0.822 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1500002C15Rik A G 4: 155,734,069 probably null Het
Acer2 T A 4: 86,917,578 *230R probably null Het
Adamts12 A G 15: 11,258,183 K527E probably damaging Het
Anks1b C A 10: 90,895,132 R937S probably damaging Het
C2cd5 G T 6: 143,012,041 C989* probably null Het
Col14a1 A G 15: 55,448,725 probably benign Het
Cramp1l T A 17: 24,982,943 T522S probably benign Het
Cyp2c70 A T 19: 40,153,572 probably benign Het
Elmod1 T A 9: 53,921,327 I224F probably benign Het
Emx2 T A 19: 59,459,589 I24N possibly damaging Het
Fam26e T C 10: 34,096,133 H102R probably benign Het
Fga A T 3: 83,029,154 I86F probably damaging Het
Fig4 C A 10: 41,232,102 probably null Het
Gm10234 T C 6: 95,322,137 probably null Het
Gm12588 A T 11: 121,906,735 I96N probably benign Het
Grm3 A G 5: 9,511,486 I788T probably damaging Het
Homer3 A G 8: 70,290,157 K173E probably damaging Het
Kansl1l A G 1: 66,738,068 V635A probably damaging Het
Kctd3 C T 1: 188,992,662 G241R probably damaging Het
Krt8 G T 15: 101,997,670 S423R probably benign Het
Lrrc24 C A 15: 76,718,311 A125S probably benign Het
Muc4 T C 16: 32,751,426 S435P possibly damaging Het
Nfkb2 G A 19: 46,309,690 G502D probably benign Het
Nlrp6 G A 7: 140,925,190 C750Y probably damaging Het
Oxsm T C 14: 16,242,520 N83S probably benign Het
Paqr3 A G 5: 97,099,643 L202P probably benign Het
Pcdh10 T A 3: 45,380,298 L349Q probably benign Het
Ptdss2 A G 7: 141,135,391 T29A possibly damaging Het
Rbbp8nl G A 2: 180,280,989 probably benign Het
Rc3h2 A G 2: 37,382,777 probably benign Het
Ric1 A T 19: 29,595,563 Y801F probably benign Het
Sgcz A T 8: 37,640,015 S114R probably damaging Het
Tenm4 A G 7: 96,553,550 D124G probably damaging Het
Zscan22 T G 7: 12,906,471 M214R probably benign Het
Other mutations in Olfr904
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01352:Olfr904 APN 9 38464734 missense probably benign
IGL02328:Olfr904 APN 9 38464676 missense probably benign
IGL03394:Olfr904 APN 9 38464221 missense probably damaging 1.00
R0085:Olfr904 UTSW 9 38464662 missense probably benign 0.37
R0125:Olfr904 UTSW 9 38464461 nonsense probably null
R1506:Olfr904 UTSW 9 38464143 missense probably benign 0.02
R1545:Olfr904 UTSW 9 38464519 missense probably benign 0.37
R1610:Olfr904 UTSW 9 38464631 missense probably damaging 0.97
R2008:Olfr904 UTSW 9 38464241 missense probably damaging 1.00
R2424:Olfr904 UTSW 9 38464832 missense probably damaging 0.99
R3824:Olfr904 UTSW 9 38464526 missense probably benign 0.13
R3964:Olfr904 UTSW 9 38464683 missense probably benign 0.25
R4093:Olfr904 UTSW 9 38464083 missense probably null 1.00
R4454:Olfr904 UTSW 9 38464642 missense probably benign 0.03
R5650:Olfr904 UTSW 9 38464727 nonsense probably null
R6921:Olfr904 UTSW 9 38464247 missense probably benign 0.01
R7406:Olfr904 UTSW 9 38464143 missense possibly damaging 0.88
R7597:Olfr904 UTSW 9 38464506 missense probably benign 0.01
R7959:Olfr904 UTSW 9 38464915 missense probably damaging 0.99
Posted On 2014-05-07