Incidental Mutation 'IGL01968:Nars'
ID181595
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nars
Ensembl Gene ENSMUSG00000024587
Gene Nameasparaginyl-tRNA synthetase
SynonymsASNRS
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.965) question?
Stock #IGL01968
Quality Score
Status
Chromosome18
Chromosomal Location64499665-64516557 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 64507858 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 176 (C176S)
Ref Sequence ENSEMBL: ENSMUSP00000025483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025483]
Predicted Effect probably damaging
Transcript: ENSMUST00000025483
AA Change: C176S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000025483
Gene: ENSMUSG00000024587
AA Change: C176S

DomainStartEndE-ValueType
coiled coil region 80 112 N/A INTRINSIC
Pfam:tRNA_anti-codon 139 219 1.2e-12 PFAM
Pfam:tRNA-synt_2 236 554 1.8e-108 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 18 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700001L19Rik T G 13: 68,611,244 H112Q probably damaging Het
4933425L06Rik T A 13: 105,119,830 M469K probably damaging Het
Abcb4 A G 5: 8,927,913 D497G probably benign Het
Adgra2 A T 8: 27,121,235 R856* probably null Het
Chodl T A 16: 78,941,669 S138T probably damaging Het
Dnah8 C T 17: 30,656,598 R465* probably null Het
Fgfr2 A G 7: 130,185,248 W358R probably damaging Het
Iqgap2 G T 13: 95,635,582 A1363E possibly damaging Het
Malt1 T A 18: 65,449,016 I317K probably benign Het
Mrps5 A G 2: 127,591,907 N72S probably null Het
Mst1r T A 9: 107,916,806 probably null Het
Olfr723 A T 14: 49,929,098 W149R probably damaging Het
Plxna4 T G 6: 32,215,204 D817A possibly damaging Het
Plxnb1 C T 9: 109,100,984 P303S probably benign Het
Prkd2 G T 7: 16,869,576 probably null Het
Sulf1 A T 1: 12,818,451 H320L probably damaging Het
Use1 G A 8: 71,367,067 probably benign Het
Vmn2r6 T C 3: 64,556,345 D356G possibly damaging Het
Other mutations in Nars
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01012:Nars APN 18 64504968 missense probably damaging 1.00
IGL01962:Nars APN 18 64510483 missense probably benign 0.00
IGL02288:Nars APN 18 64510535 splice site probably benign
IGL02366:Nars APN 18 64503528 missense possibly damaging 0.70
IGL02948:Nars APN 18 64505195 missense possibly damaging 0.66
FR4976:Nars UTSW 18 64510445 critical splice donor site probably benign
R0591:Nars UTSW 18 64500567 missense probably damaging 1.00
R1654:Nars UTSW 18 64512049 missense probably damaging 1.00
R1691:Nars UTSW 18 64516414 critical splice donor site probably null
R1954:Nars UTSW 18 64500564 missense probably damaging 1.00
R2006:Nars UTSW 18 64505028 missense probably damaging 1.00
R2516:Nars UTSW 18 64505016 missense probably damaging 1.00
R3433:Nars UTSW 18 64509303 missense probably damaging 1.00
R4378:Nars UTSW 18 64501353 missense probably damaging 1.00
R4667:Nars UTSW 18 64505231 missense possibly damaging 0.93
R4737:Nars UTSW 18 64516427 missense probably benign
R4877:Nars UTSW 18 64500572 nonsense probably null
R5950:Nars UTSW 18 64510485 missense possibly damaging 0.91
R6434:Nars UTSW 18 64507801 missense probably benign 0.01
R6920:Nars UTSW 18 64501400 missense probably damaging 0.99
R7082:Nars UTSW 18 64504354 missense possibly damaging 0.68
R7132:Nars UTSW 18 64507770 critical splice donor site probably null
R7504:Nars UTSW 18 64512022 missense probably benign 0.22
R8120:Nars UTSW 18 64504351 missense probably benign 0.19
R8343:Nars UTSW 18 64504387 missense probably benign 0.01
R8429:Nars UTSW 18 64501320 missense probably damaging 1.00
Posted On2014-05-07