Incidental Mutation 'IGL01969:Gpr176'
ID181619
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr176
Ensembl Gene ENSMUSG00000040133
Gene NameG protein-coupled receptor 176
SynonymsLOC381413
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01969
Quality Score
Status
Chromosome2
Chromosomal Location118277110-118373419 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to C at 118279637 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 380 (F380L)
Ref Sequence ENSEMBL: ENSMUSP00000037586 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039160]
Predicted Effect probably damaging
Transcript: ENSMUST00000039160
AA Change: F380L

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000037586
Gene: ENSMUSG00000040133
AA Change: F380L

DomainStartEndE-ValueType
Pfam:7tm_1 57 319 1.5e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128601
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171038
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189100
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afg3l1 C A 8: 123,480,431 P74H probably damaging Het
Aire T A 10: 78,042,982 D77V probably damaging Het
Ank2 T A 3: 126,953,223 H571L possibly damaging Het
Apol10b T C 15: 77,588,685 probably null Het
Cacna2d2 A T 9: 107,509,216 M181L probably benign Het
Ccnl1 T C 3: 65,948,487 probably benign Het
Chd9 A G 8: 91,033,510 E1961G possibly damaging Het
Dnajc12 C A 10: 63,395,830 H42N probably damaging Het
Eml4 T C 17: 83,445,980 V248A possibly damaging Het
Epha10 A C 4: 124,885,877 K172T probably damaging Het
Fat1 T C 8: 44,952,599 Y796H probably damaging Het
Guca1a A T 17: 47,400,343 M26K probably damaging Het
Gucy2g T G 19: 55,227,438 M501L probably benign Het
Herc2 T C 7: 56,185,831 probably benign Het
Itgav A G 2: 83,803,283 E1028G probably damaging Het
Itpr1 A G 6: 108,377,691 T179A probably damaging Het
Lpin2 A G 17: 71,231,507 T383A probably benign Het
Midn A G 10: 80,155,259 T325A probably benign Het
Mpdz A G 4: 81,358,724 Y788H probably damaging Het
Muc1 A T 3: 89,232,006 D571V probably damaging Het
Myo3a A T 2: 22,297,688 H316L probably benign Het
Nagpa T C 16: 5,195,889 K362E probably benign Het
Ola1 G A 2: 73,100,146 A266V probably benign Het
Olfr1256 A G 2: 89,835,720 I75T probably benign Het
Olfr1447 C A 19: 12,901,052 A243S possibly damaging Het
Olfr393 T C 11: 73,847,609 N172S possibly damaging Het
Otof A G 5: 30,382,483 probably benign Het
Pi4ka A C 16: 17,378,483 V105G probably benign Het
Plppr4 G T 3: 117,328,359 T190K probably damaging Het
Pnpla3 G A 15: 84,179,224 A268T probably benign Het
Ppp6r2 C T 15: 89,275,510 H467Y probably damaging Het
Prkd2 C T 7: 16,865,757 T715M probably damaging Het
Rusc2 A G 4: 43,415,738 N348S probably benign Het
Ska3 A G 14: 57,811,662 V284A probably benign Het
Slc23a1 A T 18: 35,624,754 V199D possibly damaging Het
Slc6a13 T C 6: 121,335,642 L445P probably damaging Het
Smo A T 6: 29,755,172 probably null Het
Tmem131 A G 1: 36,825,460 L564S possibly damaging Het
Ttc23l G A 15: 10,551,434 Q69* probably null Het
Other mutations in Gpr176
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0334:Gpr176 UTSW 2 118279708 missense probably benign
R0483:Gpr176 UTSW 2 118279723 missense probably damaging 0.99
R0522:Gpr176 UTSW 2 118284012 missense probably damaging 1.00
R0784:Gpr176 UTSW 2 118373052 missense possibly damaging 0.57
R1565:Gpr176 UTSW 2 118280214 missense probably benign
R1860:Gpr176 UTSW 2 118373178 missense probably damaging 1.00
R2029:Gpr176 UTSW 2 118279432 missense probably benign 0.02
R2311:Gpr176 UTSW 2 118279446 missense probably benign
R3935:Gpr176 UTSW 2 118279296 missense probably benign
R4241:Gpr176 UTSW 2 118279610 missense probably benign 0.22
R5112:Gpr176 UTSW 2 118280148 missense possibly damaging 0.88
R5927:Gpr176 UTSW 2 118373040 missense probably benign 0.03
R5996:Gpr176 UTSW 2 118283904 critical splice donor site probably null
R8172:Gpr176 UTSW 2 118284134 missense probably damaging 0.99
R8849:Gpr176 UTSW 2 118279614 missense probably damaging 0.99
Posted On2014-05-07