Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01969:Gucy2g'

181634

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gucy2g

Ensembl Gene

ENSMUSG00000055523

Gene Name

guanylate cyclase 2g

Synonyms

2410077I05Rik, GC-G

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01969

Quality Score

Status

Chromosome

Chromosomal Location

55186531-55229668 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 55215870 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Leucine at position 501 (M501L)

Ref Sequence

ENSEMBL: ENSMUSP00000068253 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069183]

AlphaFold

Q6TL19

Predicted Effect

probably benign
Transcript: ENSMUST00000069183
AA Change: M501L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000068253
Gene: ENSMUSG00000055523
AA Change: M501L

Domain	Start	End	E-Value	Type
low complexity region	27	38	N/A	INTRINSIC
Pfam:ANF_receptor	65	416	5.2e-36	PFAM
low complexity region	471	487	N/A	INTRINSIC
Pfam:Pkinase	574	826	2e-26	PFAM
Pfam:Pkinase_Tyr	577	826	6e-35	PFAM
CYCc	865	1059	6.42e-96	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Afg3l1	C	A	8: 124,207,170 (GRCm39)	P74H	probably damaging	Het
Aire	T	A	10: 77,878,816 (GRCm39)	D77V	probably damaging	Het
Ank2	T	A	3: 126,746,872 (GRCm39)	H571L	possibly damaging	Het
Apol10b	T	C	15: 77,472,885 (GRCm39)		probably null	Het
Cacna2d2	A	T	9: 107,386,415 (GRCm39)	M181L	probably benign	Het
Ccnl1	T	C	3: 65,855,908 (GRCm39)		probably benign	Het
Chd9	A	G	8: 91,760,138 (GRCm39)	E1961G	possibly damaging	Het
Dnajc12	C	A	10: 63,231,609 (GRCm39)	H42N	probably damaging	Het
Eml4	T	C	17: 83,753,409 (GRCm39)	V248A	possibly damaging	Het
Epha10	A	C	4: 124,779,670 (GRCm39)	K172T	probably damaging	Het
Fat1	T	C	8: 45,405,636 (GRCm39)	Y796H	probably damaging	Het
Gpr176	A	C	2: 118,110,118 (GRCm39)	F380L	probably damaging	Het
Guca1a	A	T	17: 47,711,268 (GRCm39)	M26K	probably damaging	Het
Herc2	T	C	7: 55,835,579 (GRCm39)		probably benign	Het
Itgav	A	G	2: 83,633,627 (GRCm39)	E1028G	probably damaging	Het
Itpr1	A	G	6: 108,354,652 (GRCm39)	T179A	probably damaging	Het
Lpin2	A	G	17: 71,538,502 (GRCm39)	T383A	probably benign	Het
Midn	A	G	10: 79,991,093 (GRCm39)	T325A	probably benign	Het
Mpdz	A	G	4: 81,276,961 (GRCm39)	Y788H	probably damaging	Het
Muc1	A	T	3: 89,139,313 (GRCm39)	D571V	probably damaging	Het
Myo3a	A	T	2: 22,302,499 (GRCm39)	H316L	probably benign	Het
Nagpa	T	C	16: 5,013,753 (GRCm39)	K362E	probably benign	Het
Ola1	G	A	2: 72,930,490 (GRCm39)	A266V	probably benign	Het
Or1e33	T	C	11: 73,738,435 (GRCm39)	N172S	possibly damaging	Het
Or4a47	A	G	2: 89,666,064 (GRCm39)	I75T	probably benign	Het
Or5b97	C	A	19: 12,878,416 (GRCm39)	A243S	possibly damaging	Het
Otof	A	G	5: 30,539,827 (GRCm39)		probably benign	Het
Pi4ka	A	C	16: 17,196,347 (GRCm39)	V105G	probably benign	Het
Plppr4	G	T	3: 117,122,008 (GRCm39)	T190K	probably damaging	Het
Pnpla3	G	A	15: 84,063,425 (GRCm39)	A268T	probably benign	Het
Ppp6r2	C	T	15: 89,159,713 (GRCm39)	H467Y	probably damaging	Het
Prkd2	C	T	7: 16,599,682 (GRCm39)	T715M	probably damaging	Het
Rusc2	A	G	4: 43,415,738 (GRCm39)	N348S	probably benign	Het
Ska3	A	G	14: 58,049,119 (GRCm39)	V284A	probably benign	Het
Slc23a1	A	T	18: 35,757,807 (GRCm39)	V199D	possibly damaging	Het
Slc6a13	T	C	6: 121,312,601 (GRCm39)	L445P	probably damaging	Het
Smo	A	T	6: 29,755,171 (GRCm39)		probably null	Het
Tmem131	A	G	1: 36,864,541 (GRCm39)	L564S	possibly damaging	Het
Ttc23l	G	A	15: 10,551,520 (GRCm39)	Q69*	probably null	Het

Other mutations in Gucy2g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00801:Gucy2g	APN	19	55,221,535 (GRCm39)	missense	probably benign	0.01
IGL01954:Gucy2g	APN	19	55,187,123 (GRCm39)	missense	probably benign	0.01
IGL02164:Gucy2g	APN	19	55,226,455 (GRCm39)	missense	probably benign
IGL02534:Gucy2g	APN	19	55,229,500 (GRCm39)	missense	probably damaging	1.00
IGL02667:Gucy2g	APN	19	55,194,609 (GRCm39)	missense	possibly damaging	0.64
IGL02755:Gucy2g	APN	19	55,198,786 (GRCm39)	missense	probably benign	0.10
IGL03187:Gucy2g	APN	19	55,219,484 (GRCm39)	missense	possibly damaging	0.91
IGL03354:Gucy2g	APN	19	55,221,512 (GRCm39)	missense	possibly damaging	0.95
PIT4366001:Gucy2g	UTSW	19	55,226,214 (GRCm39)	missense	probably null	0.51
R0040:Gucy2g	UTSW	19	55,205,734 (GRCm39)	missense	possibly damaging	0.73
R0126:Gucy2g	UTSW	19	55,229,598 (GRCm39)	missense	probably benign
R0318:Gucy2g	UTSW	19	55,226,230 (GRCm39)	missense	probably benign	0.00
R0576:Gucy2g	UTSW	19	55,187,202 (GRCm39)	missense	probably damaging	1.00
R0604:Gucy2g	UTSW	19	55,191,519 (GRCm39)	missense	probably benign	0.00
R0962:Gucy2g	UTSW	19	55,198,716 (GRCm39)	nonsense	probably null
R1348:Gucy2g	UTSW	19	55,211,338 (GRCm39)	missense	possibly damaging	0.68
R1458:Gucy2g	UTSW	19	55,203,468 (GRCm39)	splice site	probably benign
R1693:Gucy2g	UTSW	19	55,211,358 (GRCm39)	missense	probably damaging	1.00
R1795:Gucy2g	UTSW	19	55,187,973 (GRCm39)	missense	probably damaging	1.00
R1804:Gucy2g	UTSW	19	55,198,741 (GRCm39)	missense	probably benign	0.34
R1830:Gucy2g	UTSW	19	55,211,362 (GRCm39)	missense	possibly damaging	0.94
R1902:Gucy2g	UTSW	19	55,198,669 (GRCm39)	missense	probably benign	0.20
R1927:Gucy2g	UTSW	19	55,226,191 (GRCm39)	missense	probably benign	0.02
R1969:Gucy2g	UTSW	19	55,221,485 (GRCm39)	missense	probably benign	0.42
R1969:Gucy2g	UTSW	19	55,211,328 (GRCm39)	missense	possibly damaging	0.90
R2071:Gucy2g	UTSW	19	55,210,772 (GRCm39)	missense	possibly damaging	0.72
R2842:Gucy2g	UTSW	19	55,229,379 (GRCm39)	missense	probably damaging	1.00
R2971:Gucy2g	UTSW	19	55,198,708 (GRCm39)	missense	probably damaging	1.00
R4202:Gucy2g	UTSW	19	55,218,201 (GRCm39)	missense	possibly damaging	0.96
R4405:Gucy2g	UTSW	19	55,226,269 (GRCm39)	missense	probably benign	0.08
R4407:Gucy2g	UTSW	19	55,226,269 (GRCm39)	missense	probably benign	0.08
R4614:Gucy2g	UTSW	19	55,190,579 (GRCm39)	nonsense	probably null
R4671:Gucy2g	UTSW	19	55,226,500 (GRCm39)	missense	probably damaging	1.00
R4684:Gucy2g	UTSW	19	55,194,688 (GRCm39)	missense	probably damaging	1.00
R4837:Gucy2g	UTSW	19	55,214,485 (GRCm39)	missense	probably benign
R4969:Gucy2g	UTSW	19	55,214,445 (GRCm39)	missense	probably benign
R5050:Gucy2g	UTSW	19	55,229,367 (GRCm39)	missense	probably benign	0.05
R5059:Gucy2g	UTSW	19	55,214,503 (GRCm39)	missense	probably benign	0.00
R5070:Gucy2g	UTSW	19	55,218,219 (GRCm39)	missense	probably damaging	0.98
R5288:Gucy2g	UTSW	19	55,203,548 (GRCm39)	missense	probably damaging	1.00
R5384:Gucy2g	UTSW	19	55,203,548 (GRCm39)	missense	probably damaging	1.00
R5386:Gucy2g	UTSW	19	55,203,548 (GRCm39)	missense	probably damaging	1.00
R5497:Gucy2g	UTSW	19	55,187,133 (GRCm39)	missense	probably benign	0.00
R5531:Gucy2g	UTSW	19	55,229,572 (GRCm39)	missense	probably benign	0.24
R5536:Gucy2g	UTSW	19	55,226,359 (GRCm39)	missense	probably benign	0.05
R5679:Gucy2g	UTSW	19	55,219,511 (GRCm39)	missense	possibly damaging	0.87
R5715:Gucy2g	UTSW	19	55,221,587 (GRCm39)	missense	possibly damaging	0.93
R5941:Gucy2g	UTSW	19	55,203,563 (GRCm39)	missense	probably damaging	1.00
R6250:Gucy2g	UTSW	19	55,205,856 (GRCm39)	missense	probably damaging	0.99
R6288:Gucy2g	UTSW	19	55,215,945 (GRCm39)	missense	probably benign	0.01
R6378:Gucy2g	UTSW	19	55,229,377 (GRCm39)	missense	probably benign	0.00
R6605:Gucy2g	UTSW	19	55,229,460 (GRCm39)	missense	probably damaging	1.00
R7020:Gucy2g	UTSW	19	55,221,482 (GRCm39)	missense	probably damaging	0.98
R7064:Gucy2g	UTSW	19	55,198,764 (GRCm39)	missense	probably benign	0.01
R7078:Gucy2g	UTSW	19	55,229,583 (GRCm39)	missense	probably damaging	1.00
R7402:Gucy2g	UTSW	19	55,194,725 (GRCm39)	missense	probably damaging	1.00
R7539:Gucy2g	UTSW	19	55,191,586 (GRCm39)	missense	probably damaging	0.99
R7561:Gucy2g	UTSW	19	55,194,772 (GRCm39)	missense	probably benign	0.38
R7583:Gucy2g	UTSW	19	55,224,047 (GRCm39)	missense	probably damaging	1.00
R7804:Gucy2g	UTSW	19	55,216,584 (GRCm39)	missense	probably benign	0.02
R7880:Gucy2g	UTSW	19	55,194,712 (GRCm39)	missense	probably damaging	1.00
R8442:Gucy2g	UTSW	19	55,205,833 (GRCm39)	missense	probably benign	0.00
R8559:Gucy2g	UTSW	19	55,198,786 (GRCm39)	missense	probably benign	0.10
R8970:Gucy2g	UTSW	19	55,191,478 (GRCm39)	missense	possibly damaging	0.56
R8972:Gucy2g	UTSW	19	55,226,406 (GRCm39)	missense	probably benign	0.17
R9085:Gucy2g	UTSW	19	55,221,597 (GRCm39)	nonsense	probably null
R9390:Gucy2g	UTSW	19	55,190,607 (GRCm39)	missense	probably null	1.00
R9462:Gucy2g	UTSW	19	55,221,469 (GRCm39)	critical splice donor site	probably null
R9502:Gucy2g	UTSW	19	55,198,816 (GRCm39)	missense	probably damaging	1.00
R9610:Gucy2g	UTSW	19	55,194,605 (GRCm39)	missense	probably damaging	1.00
R9611:Gucy2g	UTSW	19	55,194,605 (GRCm39)	missense	probably damaging	1.00
R9644:Gucy2g	UTSW	19	55,219,537 (GRCm39)	missense	probably benign	0.05
Z1177:Gucy2g	UTSW	19	55,198,809 (GRCm39)	missense	probably benign	0.00

Posted On

2014-05-07