Incidental Mutation 'IGL01972:Tmem17'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem17
Ensembl Gene ENSMUSG00000049904
Gene Nametransmembrane protein 17
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.201) question?
Stock #IGL01972
Quality Score
Chromosomal Location22512088-22519234 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 22517265 bp
Amino Acid Change Serine to Glycine at position 60 (S60G)
Ref Sequence ENSEMBL: ENSMUSP00000051414 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059319]
Predicted Effect probably benign
Transcript: ENSMUST00000059319
AA Change: S60G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000051414
Gene: ENSMUSG00000049904
AA Change: S60G

Pfam:Transmemb_17 45 152 3.1e-33 PFAM
low complexity region 182 192 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahr T G 12: 35,504,449 D557A possibly damaging Het
Akap11 T C 14: 78,507,857 Q1697R probably damaging Het
Alpi T A 1: 87,099,709 T312S probably damaging Het
Cacna1b C A 2: 24,635,095 probably null Het
Car5a C T 8: 121,927,082 probably null Het
Cubn T C 2: 13,446,072 T841A possibly damaging Het
Eml6 A T 11: 29,838,451 F545I possibly damaging Het
Fam114a2 G A 11: 57,509,394 T156I probably damaging Het
Fam160a2 T C 7: 105,390,145 N5S probably damaging Het
Fbxl21 C T 13: 56,536,859 R259* probably null Het
Gm5117 C T 8: 31,737,759 noncoding transcript Het
Hc T C 2: 34,983,772 Y1650C probably damaging Het
Med12l C A 3: 59,261,893 T1568K probably damaging Het
Olfr429 G T 1: 174,089,421 C127F probably damaging Het
Olfr701 A G 7: 106,818,532 I150V probably benign Het
Olfr996 T C 2: 85,579,773 F178S probably damaging Het
Orm3 A G 4: 63,359,326 S184G probably benign Het
Padi1 A G 4: 140,818,859 probably benign Het
Rnf133 T C 6: 23,648,989 T357A probably benign Het
Skiv2l2 T C 13: 112,881,061 K853E probably damaging Het
Ubqlnl G T 7: 104,149,697 Q198K probably benign Het
Vmn1r69 A T 7: 10,580,659 Y48* probably null Het
Zfp658 G A 7: 43,572,710 W136* probably null Het
Other mutations in Tmem17
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1179:Tmem17 UTSW 11 22518454 missense probably damaging 1.00
R1538:Tmem17 UTSW 11 22517266 missense possibly damaging 0.78
R5425:Tmem17 UTSW 11 22518624 missense probably benign
R5590:Tmem17 UTSW 11 22517450 missense probably benign 0.02
R6025:Tmem17 UTSW 11 22518659 makesense probably null
R6257:Tmem17 UTSW 11 22512297 start gained probably benign
R6518:Tmem17 UTSW 11 22517427 missense possibly damaging 0.91
R6981:Tmem17 UTSW 11 22518508 missense possibly damaging 0.49
R7412:Tmem17 UTSW 11 22518645 missense probably benign 0.00
R7955:Tmem17 UTSW 11 22518490 missense possibly damaging 0.88
Posted On2014-05-07