Incidental Mutation 'IGL01972:Orm3'
ID181667
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Orm3
Ensembl Gene ENSMUSG00000028359
Gene Nameorosomucoid 3
SynonymsOrm-3, Agp-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #IGL01972
Quality Score
Status
Chromosome4
Chromosomal Location63356162-63359511 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 63359326 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 184 (S184G)
Ref Sequence ENSEMBL: ENSMUSP00000006687 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006687] [ENSMUST00000075341]
Predicted Effect probably benign
Transcript: ENSMUST00000006687
AA Change: S184G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000006687
Gene: ENSMUSG00000028359
AA Change: S184G

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Lipocalin 40 180 4.8e-25 PFAM
low complexity region 185 199 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000075341
SMART Domains Protein: ENSMUSP00000074810
Gene: ENSMUSG00000061540

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:Lipocalin 41 181 1.5e-23 PFAM
low complexity region 186 200 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahr T G 12: 35,504,449 D557A possibly damaging Het
Akap11 T C 14: 78,507,857 Q1697R probably damaging Het
Alpi T A 1: 87,099,709 T312S probably damaging Het
Cacna1b C A 2: 24,635,095 probably null Het
Car5a C T 8: 121,927,082 probably null Het
Cubn T C 2: 13,446,072 T841A possibly damaging Het
Eml6 A T 11: 29,838,451 F545I possibly damaging Het
Fam114a2 G A 11: 57,509,394 T156I probably damaging Het
Fam160a2 T C 7: 105,390,145 N5S probably damaging Het
Fbxl21 C T 13: 56,536,859 R259* probably null Het
Gm5117 C T 8: 31,737,759 noncoding transcript Het
Hc T C 2: 34,983,772 Y1650C probably damaging Het
Med12l C A 3: 59,261,893 T1568K probably damaging Het
Olfr429 G T 1: 174,089,421 C127F probably damaging Het
Olfr701 A G 7: 106,818,532 I150V probably benign Het
Olfr996 T C 2: 85,579,773 F178S probably damaging Het
Padi1 A G 4: 140,818,859 probably benign Het
Rnf133 T C 6: 23,648,989 T357A probably benign Het
Skiv2l2 T C 13: 112,881,061 K853E probably damaging Het
Tmem17 A G 11: 22,517,265 S60G probably benign Het
Ubqlnl G T 7: 104,149,697 Q198K probably benign Het
Vmn1r69 A T 7: 10,580,659 Y48* probably null Het
Zfp658 G A 7: 43,572,710 W136* probably null Het
Other mutations in Orm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
P0033:Orm3 UTSW 4 63356302 missense probably damaging 0.99
R0070:Orm3 UTSW 4 63356646 missense probably benign 0.00
R0398:Orm3 UTSW 4 63357648 missense probably benign
R1169:Orm3 UTSW 4 63357848 missense probably damaging 0.97
R1551:Orm3 UTSW 4 63356909 critical splice acceptor site probably null
R3975:Orm3 UTSW 4 63356158 splice site probably null
R6767:Orm3 UTSW 4 63356294 missense probably damaging 1.00
R6997:Orm3 UTSW 4 63356943 missense probably damaging 1.00
R7128:Orm3 UTSW 4 63357825 missense probably benign 0.25
R7708:Orm3 UTSW 4 63357813 missense probably damaging 1.00
R8056:Orm3 UTSW 4 63359357 missense probably benign
R8401:Orm3 UTSW 4 63356230 missense possibly damaging 0.68
X0065:Orm3 UTSW 4 63356698 missense probably benign 0.06
Posted On2014-05-07