Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01974:Styxl2'

181686

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Styxl2

Ensembl Gene

ENSMUSG00000026564

Gene Name

serine/threonine/tyrosine interacting like 2

Synonyms

C130085G02Rik, Dusp27

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01974

Quality Score

Status

Chromosome

Chromosomal Location

165925717-165955467 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 165928105 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 502 (C502*)

Ref Sequence

ENSEMBL: ENSMUSP00000141564 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000085992] [ENSMUST00000192369]

AlphaFold

Q148W8

Predicted Effect

probably null
Transcript: ENSMUST00000085992
AA Change: C502*

SMART Domains

Protein: ENSMUSP00000083155
Gene: ENSMUSG00000026564
AA Change: C502*

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000192369
AA Change: C502*

SMART Domains

Protein: ENSMUSP00000141564
Gene: ENSMUSG00000026564
AA Change: C502*

Domain	Start	End	E-Value	Type
low complexity region	6	20	N/A	INTRINSIC
DSPc	133	277	2.45e-30	SMART
low complexity region	339	348	N/A	INTRINSIC
low complexity region	404	425	N/A	INTRINSIC
low complexity region	429	439	N/A	INTRINSIC
low complexity region	618	635	N/A	INTRINSIC
low complexity region	655	666	N/A	INTRINSIC
low complexity region	773	788	N/A	INTRINSIC
coiled coil region	813	839	N/A	INTRINSIC
low complexity region	851	860	N/A	INTRINSIC
low complexity region	936	950	N/A	INTRINSIC
low complexity region	1001	1019	N/A	INTRINSIC
low complexity region	1026	1040	N/A	INTRINSIC
low complexity region	1074	1091	N/A	INTRINSIC
low complexity region	1108	1120	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	T	C	14: 32,381,762 (GRCm39)	D1401G	possibly damaging	Het
Adamts2	G	A	11: 50,667,001 (GRCm39)	G433S	probably damaging	Het
Cacna2d2	A	C	9: 107,394,621 (GRCm39)	S598R	probably benign	Het
Cdkl3	A	G	11: 51,902,064 (GRCm39)	Q91R	probably damaging	Het
Celf2	T	C	2: 6,608,842 (GRCm39)	Y313C	probably damaging	Het
Clint1	C	A	11: 45,799,862 (GRCm39)	N558K	probably benign	Het
Dcbld1	A	G	10: 52,180,777 (GRCm39)	H147R	probably benign	Het
Ednrb	A	C	14: 104,058,254 (GRCm39)	Y350D	probably damaging	Het
Elp2	C	T	18: 24,759,260 (GRCm39)	P539L	probably damaging	Het
Fam217b	G	A	2: 178,063,020 (GRCm39)	R328Q	probably damaging	Het
Gm9991	G	T	1: 90,603,197 (GRCm39)		noncoding transcript	Het
Herc4	T	G	10: 63,135,020 (GRCm39)		probably null	Het
Hus1	T	C	11: 8,950,088 (GRCm39)	N211S	possibly damaging	Het
Immt	A	G	6: 71,849,842 (GRCm39)	D454G	probably damaging	Het
Itga4	G	A	2: 79,103,471 (GRCm39)		probably benign	Het
Kank1	A	T	19: 25,387,596 (GRCm39)	N423I	possibly damaging	Het
Kynu	T	A	2: 43,571,352 (GRCm39)		probably benign	Het
Mycbp2	A	C	14: 103,380,647 (GRCm39)	S3670A	possibly damaging	Het
Ndufv3	T	C	17: 31,740,583 (GRCm39)	V30A	probably benign	Het
Or8k17	G	T	2: 86,066,304 (GRCm39)	L292I	probably benign	Het
Per2	C	T	1: 91,351,440 (GRCm39)	R1022Q	probably benign	Het
Rad23a	T	C	8: 85,565,568 (GRCm39)	E30G	probably damaging	Het
Ropn1l	T	A	15: 31,449,255 (GRCm39)	Y91F	probably benign	Het
Sertad4	C	A	1: 192,529,274 (GRCm39)	E181*	probably null	Het
Tnfrsf1b	G	A	4: 144,942,421 (GRCm39)	P454L	probably damaging	Het
Ttbk2	G	A	2: 120,616,564 (GRCm39)	R110W	probably damaging	Het
Usp17le	G	T	7: 104,417,642 (GRCm39)	S500Y	probably benign	Het

Other mutations in Styxl2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00706:Styxl2	APN	1	165,928,121 (GRCm39)	missense	probably benign	0.00
IGL00973:Styxl2	APN	1	165,927,027 (GRCm39)	missense	probably benign
IGL01331:Styxl2	APN	1	165,935,749 (GRCm39)	missense	probably damaging	1.00
IGL01466:Styxl2	APN	1	165,928,073 (GRCm39)	missense	probably damaging	1.00
IGL01572:Styxl2	APN	1	165,927,941 (GRCm39)	missense	probably benign	0.18
IGL01906:Styxl2	APN	1	165,927,092 (GRCm39)	missense	probably damaging	1.00
IGL02112:Styxl2	APN	1	165,927,240 (GRCm39)	nonsense	probably null
IGL02805:Styxl2	APN	1	165,926,630 (GRCm39)	missense	probably damaging	1.00
IGL03343:Styxl2	APN	1	165,927,017 (GRCm39)	missense	probably benign	0.00
R0116:Styxl2	UTSW	1	165,927,270 (GRCm39)	missense	probably benign	0.19
R0367:Styxl2	UTSW	1	165,928,332 (GRCm39)	missense	probably benign	0.05
R0499:Styxl2	UTSW	1	165,926,670 (GRCm39)	missense	probably benign	0.00
R0542:Styxl2	UTSW	1	165,928,853 (GRCm39)	missense	possibly damaging	0.90
R1312:Styxl2	UTSW	1	165,926,860 (GRCm39)	missense	possibly damaging	0.46
R1572:Styxl2	UTSW	1	165,927,024 (GRCm39)	missense	possibly damaging	0.68
R1598:Styxl2	UTSW	1	165,937,828 (GRCm39)	missense	probably benign	0.10
R1858:Styxl2	UTSW	1	165,928,415 (GRCm39)	missense	possibly damaging	0.87
R2021:Styxl2	UTSW	1	165,928,392 (GRCm39)	missense	probably benign	0.00
R2970:Styxl2	UTSW	1	165,926,798 (GRCm39)	missense	probably benign	0.04
R3727:Styxl2	UTSW	1	165,927,075 (GRCm39)	missense	probably damaging	1.00
R4041:Styxl2	UTSW	1	165,927,680 (GRCm39)	missense	probably benign	0.01
R4245:Styxl2	UTSW	1	165,928,685 (GRCm39)	missense	probably damaging	1.00
R4955:Styxl2	UTSW	1	165,935,661 (GRCm39)	missense	probably damaging	1.00
R4967:Styxl2	UTSW	1	165,954,675 (GRCm39)	missense	probably damaging	1.00
R5040:Styxl2	UTSW	1	165,927,914 (GRCm39)	missense	probably benign	0.17
R5342:Styxl2	UTSW	1	165,937,819 (GRCm39)	missense	probably benign	0.01
R5467:Styxl2	UTSW	1	165,939,599 (GRCm39)	critical splice donor site	probably null
R5742:Styxl2	UTSW	1	165,927,023 (GRCm39)	missense	probably benign	0.00
R6222:Styxl2	UTSW	1	165,926,214 (GRCm39)	missense	probably benign	0.26
R6239:Styxl2	UTSW	1	165,926,388 (GRCm39)	missense	probably damaging	1.00
R6531:Styxl2	UTSW	1	165,937,615 (GRCm39)	splice site	probably null
R6586:Styxl2	UTSW	1	165,928,454 (GRCm39)	missense	possibly damaging	0.79
R6958:Styxl2	UTSW	1	165,935,565 (GRCm39)	missense	probably damaging	1.00
R7006:Styxl2	UTSW	1	165,926,663 (GRCm39)	missense	probably benign
R7111:Styxl2	UTSW	1	165,954,723 (GRCm39)	missense	possibly damaging	0.66
R7310:Styxl2	UTSW	1	165,926,300 (GRCm39)	missense	possibly damaging	0.46
R7312:Styxl2	UTSW	1	165,954,676 (GRCm39)	missense	probably damaging	0.99
R7378:Styxl2	UTSW	1	165,939,632 (GRCm39)	nonsense	probably null
R7398:Styxl2	UTSW	1	165,928,044 (GRCm39)	missense	probably damaging	1.00
R7442:Styxl2	UTSW	1	165,928,584 (GRCm39)	missense	probably benign	0.01
R7569:Styxl2	UTSW	1	165,935,604 (GRCm39)	missense	probably damaging	1.00
R7920:Styxl2	UTSW	1	165,927,465 (GRCm39)	missense	possibly damaging	0.72
R7954:Styxl2	UTSW	1	165,926,849 (GRCm39)	missense	probably benign	0.05
R7972:Styxl2	UTSW	1	165,926,708 (GRCm39)	missense	probably damaging	1.00
R8186:Styxl2	UTSW	1	165,927,648 (GRCm39)	missense	probably damaging	1.00
R8354:Styxl2	UTSW	1	165,935,702 (GRCm39)	missense	probably damaging	1.00
R8454:Styxl2	UTSW	1	165,935,702 (GRCm39)	missense	probably damaging	1.00
R8535:Styxl2	UTSW	1	165,928,730 (GRCm39)	missense	probably benign	0.01
R9419:Styxl2	UTSW	1	165,927,755 (GRCm39)	missense	probably damaging	1.00
R9493:Styxl2	UTSW	1	165,926,410 (GRCm39)	missense	probably damaging	1.00
R9694:Styxl2	UTSW	1	165,928,654 (GRCm39)	missense	probably damaging	1.00
Z1088:Styxl2	UTSW	1	165,926,852 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07