Incidental Mutation 'IGL01974:Sertad4'
ID181689
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sertad4
Ensembl Gene ENSMUSG00000016262
Gene NameSERTA domain containing 4
SynonymsC130018M11Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.223) question?
Stock #IGL01974
Quality Score
Status
Chromosome1
Chromosomal Location192844488-192855756 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) C to A at 192846966 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 181 (E181*)
Ref Sequence ENSEMBL: ENSMUSP00000116176 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016406] [ENSMUST00000155503] [ENSMUST00000155579]
Predicted Effect probably null
Transcript: ENSMUST00000016406
AA Change: E181*
SMART Domains Protein: ENSMUSP00000016406
Gene: ENSMUSG00000016262
AA Change: E181*

DomainStartEndE-ValueType
low complexity region 31 47 N/A INTRINSIC
Pfam:SERTA 108 144 1.1e-18 PFAM
low complexity region 212 262 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000155503
SMART Domains Protein: ENSMUSP00000142132
Gene: ENSMUSG00000016262

DomainStartEndE-ValueType
low complexity region 31 47 N/A INTRINSIC
Pfam:SERTA 108 144 1.5e-17 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000155579
AA Change: E181*
SMART Domains Protein: ENSMUSP00000116176
Gene: ENSMUSG00000016262
AA Change: E181*

DomainStartEndE-ValueType
low complexity region 31 47 N/A INTRINSIC
Pfam:SERTA 108 144 3.5e-20 PFAM
low complexity region 212 262 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188648
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190576
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik T C 14: 32,659,805 D1401G possibly damaging Het
Adamts2 G A 11: 50,776,174 G433S probably damaging Het
Cacna2d2 A C 9: 107,517,422 S598R probably benign Het
Cdkl3 A G 11: 52,011,237 Q91R probably damaging Het
Celf2 T C 2: 6,604,031 Y313C probably damaging Het
Clint1 C A 11: 45,909,035 N558K probably benign Het
Dcbld1 A G 10: 52,304,681 H147R probably benign Het
Dusp27 A T 1: 166,100,536 C502* probably null Het
Ednrb A C 14: 103,820,818 Y350D probably damaging Het
Elp2 C T 18: 24,626,203 P539L probably damaging Het
Fam217b G A 2: 178,421,227 R328Q probably damaging Het
Gm9991 G T 1: 90,675,475 noncoding transcript Het
Herc4 T G 10: 63,299,241 probably null Het
Hus1 T C 11: 9,000,088 N211S possibly damaging Het
Immt A G 6: 71,872,858 D454G probably damaging Het
Itga4 G A 2: 79,273,127 probably benign Het
Kank1 A T 19: 25,410,232 N423I possibly damaging Het
Kynu T A 2: 43,681,340 probably benign Het
Mycbp2 A C 14: 103,143,211 S3670A possibly damaging Het
Ndufv3 T C 17: 31,521,609 V30A probably benign Het
Olfr1048 G T 2: 86,235,960 L292I probably benign Het
Per2 C T 1: 91,423,718 R1022Q probably benign Het
Rad23a T C 8: 84,838,939 E30G probably damaging Het
Ropn1l T A 15: 31,449,109 Y91F probably benign Het
Tnfrsf1b G A 4: 145,215,851 P454L probably damaging Het
Ttbk2 G A 2: 120,786,083 R110W probably damaging Het
Usp17le G T 7: 104,768,435 S500Y probably benign Het
Other mutations in Sertad4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1531:Sertad4 UTSW 1 192850950 critical splice donor site probably null
R1783:Sertad4 UTSW 1 192847032 missense probably benign 0.00
R4106:Sertad4 UTSW 1 192846742 small deletion probably benign
R5165:Sertad4 UTSW 1 192846822 missense possibly damaging 0.85
R5362:Sertad4 UTSW 1 192847106 missense probably damaging 1.00
R6243:Sertad4 UTSW 1 192850949 splice site probably null
R7438:Sertad4 UTSW 1 192846710 missense possibly damaging 0.71
RF001:Sertad4 UTSW 1 192847178 missense probably damaging 1.00
Z1088:Sertad4 UTSW 1 192847031 missense probably damaging 0.96
Posted On2014-05-07