Incidental Mutation 'IGL01977:Gnl2'
ID181745
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gnl2
Ensembl Gene ENSMUSG00000028869
Gene Nameguanine nucleotide binding protein-like 2 (nucleolar)
SynonymsNgp-1
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.968) question?
Stock #IGL01977
Quality Score
Status
Chromosome4
Chromosomal Location125016585-125055380 bp(+) (GRCm38)
Type of Mutationsplice site (5 bp from exon)
DNA Base Change (assembly) G to A at 125047612 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000030684 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030684]
Predicted Effect probably null
Transcript: ENSMUST00000030684
SMART Domains Protein: ENSMUSP00000030684
Gene: ENSMUSG00000028869

DomainStartEndE-ValueType
Pfam:NGP1NT 43 174 1.2e-51 PFAM
SCOP:d1egaa1 178 261 8e-3 SMART
Pfam:FeoB_N 311 398 3.1e-6 PFAM
Pfam:MMR_HSR1 312 432 3.4e-13 PFAM
low complexity region 480 500 N/A INTRINSIC
low complexity region 551 579 N/A INTRINSIC
low complexity region 679 687 N/A INTRINSIC
low complexity region 700 710 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125078
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147390
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T A 10: 80,006,152 S1040T probably benign Het
Adam25 T C 8: 40,755,097 Y467H probably benign Het
Ank1 A G 8: 23,115,433 I1061V probably benign Het
Anxa10 T C 8: 62,076,314 E123G probably damaging Het
Arhgap35 G A 7: 16,563,203 L646F probably damaging Het
Atp8b5 A G 4: 43,320,590 probably null Het
Brap A G 5: 121,678,847 probably benign Het
Carmil3 A G 14: 55,493,536 T87A probably damaging Het
Ccdc172 A G 19: 58,552,877 D256G possibly damaging Het
Cep350 C T 1: 155,911,968 A1375T probably benign Het
Chrdl2 A T 7: 100,022,056 Q127L probably benign Het
Cyp2c29 T C 19: 39,290,897 probably benign Het
Ddi1 C A 9: 6,266,226 V48F probably benign Het
Ddrgk1 C T 2: 130,655,246 probably benign Het
Fastkd1 C T 2: 69,694,588 V626I possibly damaging Het
Fgd5 A G 6: 92,024,562 T755A probably benign Het
Fpgt G T 3: 155,088,018 T124K probably damaging Het
Got1 A T 19: 43,515,845 S46T probably benign Het
Hbb-bt G T 7: 103,813,863 H3N probably benign Het
Ikbke C T 1: 131,272,101 probably benign Het
Il2rb A G 15: 78,481,697 S467P probably benign Het
Kcnma1 A G 14: 23,530,299 probably benign Het
Ltbp2 T C 12: 84,830,199 N391D probably damaging Het
Npr3 A T 15: 11,858,718 I360N probably damaging Het
Nradd G A 9: 110,622,169 P44S possibly damaging Het
Olfr1023 G T 2: 85,887,367 C189F probably damaging Het
Olfr871 G A 9: 20,212,459 V37I possibly damaging Het
Pcdh17 A G 14: 84,533,097 E1005G possibly damaging Het
Pcdhb11 A G 18: 37,422,291 T225A possibly damaging Het
Pja2 T C 17: 64,297,826 D454G probably benign Het
Pon3 T C 6: 5,221,670 Y320C probably damaging Het
Prl2a1 A G 13: 27,806,278 D70G probably damaging Het
Proc T A 18: 32,127,419 T218S probably benign Het
Proz G T 8: 13,066,913 G155V probably damaging Het
Rab11fip3 T C 17: 26,068,003 E392G possibly damaging Het
Rab3gap2 C T 1: 185,267,023 R976* probably null Het
Shisa2 G A 14: 59,629,986 C229Y probably damaging Het
Slc2a5 T C 4: 150,142,218 V379A probably damaging Het
Slc31a2 A T 4: 62,295,960 K47N probably damaging Het
Sult2a6 G A 7: 14,253,486 T88I probably benign Het
Tbc1d14 T C 5: 36,505,037 Y302C probably damaging Het
Thumpd3 C A 6: 113,059,966 N275K possibly damaging Het
Tnks2 T C 19: 36,872,590 probably null Het
Tube1 G A 10: 39,135,045 probably benign Het
Umodl1 T A 17: 30,973,768 Y290N probably damaging Het
Usp34 G A 11: 23,452,661 E726K probably damaging Het
Vmn2r84 T A 10: 130,394,066 D59V probably benign Het
Vps11 T A 9: 44,356,219 probably benign Het
Wdr19 T C 5: 65,228,569 Y631H probably benign Het
Wdr62 G A 7: 30,258,101 H88Y probably damaging Het
Wdr93 A T 7: 79,752,505 N184I probably damaging Het
Wnk4 T A 11: 101,265,414 F473Y probably damaging Het
Zbtb16 A G 9: 48,657,183 W661R probably damaging Het
Other mutations in Gnl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02536:Gnl2 APN 4 125052608 nonsense probably null
IGL03358:Gnl2 APN 4 125052594 missense probably damaging 1.00
PIT4283001:Gnl2 UTSW 4 125046306 missense probably damaging 1.00
R0377:Gnl2 UTSW 4 125046382 splice site probably benign
R0419:Gnl2 UTSW 4 125053527 missense probably benign 0.00
R0975:Gnl2 UTSW 4 125048378 missense probably damaging 0.99
R1529:Gnl2 UTSW 4 125046306 missense probably damaging 1.00
R1550:Gnl2 UTSW 4 125044234 missense probably damaging 1.00
R1942:Gnl2 UTSW 4 125030164 missense probably benign 0.01
R2095:Gnl2 UTSW 4 125034318 missense probably damaging 1.00
R2125:Gnl2 UTSW 4 125053485 missense probably benign 0.01
R3712:Gnl2 UTSW 4 125046274 missense probably damaging 0.98
R3781:Gnl2 UTSW 4 125037606 missense probably damaging 0.99
R4656:Gnl2 UTSW 4 125040997 nonsense probably null
R4676:Gnl2 UTSW 4 125053473 missense possibly damaging 0.83
R4710:Gnl2 UTSW 4 125053459 missense probably benign 0.01
R4734:Gnl2 UTSW 4 125041018 missense probably benign
R4916:Gnl2 UTSW 4 125043692 missense probably damaging 1.00
R5106:Gnl2 UTSW 4 125053536 critical splice donor site probably null
R5310:Gnl2 UTSW 4 125052840 missense probably benign 0.00
R5506:Gnl2 UTSW 4 125055365 utr 3 prime probably benign
R5967:Gnl2 UTSW 4 125041030 missense probably benign 0.00
R6184:Gnl2 UTSW 4 125054229 critical splice donor site probably null
R6395:Gnl2 UTSW 4 125046265 missense probably damaging 0.99
R6432:Gnl2 UTSW 4 125052560 missense possibly damaging 0.86
R6672:Gnl2 UTSW 4 125048393 missense probably damaging 1.00
R7657:Gnl2 UTSW 4 125030158 missense probably benign 0.00
RF003:Gnl2 UTSW 4 125043725 critical splice donor site probably null
Posted On2014-05-07