Incidental Mutation 'IGL01978:Olfr190'
ID181756
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr190
Ensembl Gene ENSMUSG00000064006
Gene Nameolfactory receptor 190
SynonymsMOR183-4, GA_x54KRFPKG5P-55303207-55302284
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL01978
Quality Score
Status
Chromosome16
Chromosomal Location59067140-59078005 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 59074267 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Lysine at position 271 (I271K)
Ref Sequence ENSEMBL: ENSMUSP00000148991 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071243] [ENSMUST00000206214] [ENSMUST00000215687] [ENSMUST00000216495]
Predicted Effect probably benign
Transcript: ENSMUST00000071243
AA Change: I271K

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000071224
Gene: ENSMUSG00000064006
AA Change: I271K

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.1e-46 PFAM
Pfam:7tm_1 39 288 2.8e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206214
AA Change: I271K
Predicted Effect probably benign
Transcript: ENSMUST00000215687
AA Change: I271K

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
Predicted Effect probably benign
Transcript: ENSMUST00000216495
AA Change: I271K

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A T 15: 8,219,382 N1805I probably damaging Het
9830107B12Rik T A 17: 48,145,993 T6S probably damaging Het
Acot5 T C 12: 84,075,398 V252A possibly damaging Het
Bmper A T 9: 23,381,441 N349Y probably damaging Het
Brap A G 5: 121,678,847 probably benign Het
Col9a2 G A 4: 121,044,666 G139E unknown Het
Cyp2j8 A C 4: 96,504,009 probably null Het
Dcbld2 A G 16: 58,464,319 D612G probably benign Het
Dsc3 C T 18: 19,974,196 R456Q possibly damaging Het
Fat2 T C 11: 55,270,146 T3253A probably benign Het
Hoxc12 T A 15: 102,936,864 H4Q probably damaging Het
Il6st A G 13: 112,497,357 E445G possibly damaging Het
Ipo8 T C 6: 148,777,289 E937G probably benign Het
Kif5a A C 10: 127,245,739 D185E probably benign Het
Klhl38 T C 15: 58,315,089 D495G probably damaging Het
Klra5 A G 6: 129,911,430 V11A probably benign Het
Lrch1 G A 14: 74,786,342 T581M probably damaging Het
Mecom A G 3: 29,963,166 I450T probably damaging Het
Mrgprb2 C A 7: 48,552,564 V138L probably damaging Het
Muc15 G A 2: 110,731,596 A126T probably benign Het
Mybpc1 A T 10: 88,531,770 I522K probably damaging Het
Nectin1 G A 9: 43,792,147 R234H probably damaging Het
Olfr1450 T C 19: 12,954,042 F151S probably benign Het
Pdia6 T A 12: 17,274,422 H91Q possibly damaging Het
Pfkfb4 A T 9: 109,028,942 H445L probably damaging Het
Pkd1l1 T C 11: 8,961,336 T314A unknown Het
Rb1cc1 A G 1: 6,238,368 D159G probably damaging Het
Rhoh T A 5: 65,892,688 S100R probably benign Het
Rsbn1 T A 3: 103,961,500 D618E probably damaging Het
Slc25a47 T C 12: 108,851,190 V4A probably damaging Het
Svs3b T A 2: 164,256,621 M1L probably benign Het
Thsd7a T C 6: 12,331,006 N1379S probably benign Het
Tmed3 T C 9: 89,704,753 D58G probably benign Het
Trh G A 6: 92,242,615 A240V probably benign Het
Ubox5 A T 2: 130,600,452 V105E probably benign Het
Vmn2r67 A G 7: 85,151,441 probably null Het
Vps13c A G 9: 67,930,643 H1825R probably benign Het
Wasf1 C A 10: 40,936,201 P329T unknown Het
Wee2 T C 6: 40,455,153 F219L probably damaging Het
Zp3r T C 1: 130,598,941 D175G probably damaging Het
Other mutations in Olfr190
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00953:Olfr190 APN 16 59074689 nonsense probably null
IGL01011:Olfr190 APN 16 59074430 missense probably benign 0.10
IGL01453:Olfr190 APN 16 59074769 missense probably benign 0.00
IGL02348:Olfr190 APN 16 59074949 missense probably damaging 0.99
IGL02423:Olfr190 APN 16 59074267 missense probably benign 0.33
IGL02628:Olfr190 APN 16 59074792 missense probably benign 0.01
R0220:Olfr190 UTSW 16 59074732 missense probably damaging 1.00
R0471:Olfr190 UTSW 16 59074270 missense probably benign 0.01
R1697:Olfr190 UTSW 16 59074907 missense probably damaging 1.00
R3009:Olfr190 UTSW 16 59074987 missense probably benign 0.01
R3011:Olfr190 UTSW 16 59074987 missense probably benign 0.01
R3027:Olfr190 UTSW 16 59074967 missense probably benign 0.00
R4080:Olfr190 UTSW 16 59074256 missense probably damaging 0.96
R4482:Olfr190 UTSW 16 59074923 missense probably benign 0.02
R4895:Olfr190 UTSW 16 59074657 missense probably benign 0.09
R5409:Olfr190 UTSW 16 59074196 missense possibly damaging 0.94
R5825:Olfr190 UTSW 16 59074661 missense probably benign 0.01
R6146:Olfr190 UTSW 16 59074714 missense probably benign 0.05
R6249:Olfr190 UTSW 16 59074432 missense probably damaging 1.00
R6996:Olfr190 UTSW 16 59074192 missense probably benign 0.00
R7283:Olfr190 UTSW 16 59074192 missense probably benign
R7707:Olfr190 UTSW 16 59074271 missense possibly damaging 0.52
R8381:Olfr190 UTSW 16 59074862 missense probably damaging 1.00
R8507:Olfr190 UTSW 16 59074880 missense possibly damaging 0.81
R8887:Olfr190 UTSW 16 59074483 missense possibly damaging 0.93
Posted On2014-05-07