Incidental Mutation 'IGL01978:Svs3b'
ID181760
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Svs3b
Ensembl Gene ENSMUSG00000050383
Gene Nameseminal vesicle secretory protein 3B
Synonyms9530004A22Rik, SVS III
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.051) question?
Stock #IGL01978
Quality Score
Status
Chromosome2
Chromosomal Location164254363-164256640 bp(-) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) T to A at 164256621 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 1 (M1L)
Ref Sequence ENSEMBL: ENSMUSP00000062011 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063132]
Predicted Effect probably benign
Transcript: ENSMUST00000063132
AA Change: M1L

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000062011
Gene: ENSMUSG00000050383
AA Change: M1L

DomainStartEndE-ValueType
Pfam:Semenogelin 1 146 7.4e-10 PFAM
low complexity region 210 225 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A T 15: 8,219,382 N1805I probably damaging Het
9830107B12Rik T A 17: 48,145,993 T6S probably damaging Het
Acot5 T C 12: 84,075,398 V252A possibly damaging Het
Bmper A T 9: 23,381,441 N349Y probably damaging Het
Brap A G 5: 121,678,847 probably benign Het
Col9a2 G A 4: 121,044,666 G139E unknown Het
Cyp2j8 A C 4: 96,504,009 probably null Het
Dcbld2 A G 16: 58,464,319 D612G probably benign Het
Dsc3 C T 18: 19,974,196 R456Q possibly damaging Het
Fat2 T C 11: 55,270,146 T3253A probably benign Het
Hoxc12 T A 15: 102,936,864 H4Q probably damaging Het
Il6st A G 13: 112,497,357 E445G possibly damaging Het
Ipo8 T C 6: 148,777,289 E937G probably benign Het
Kif5a A C 10: 127,245,739 D185E probably benign Het
Klhl38 T C 15: 58,315,089 D495G probably damaging Het
Klra5 A G 6: 129,911,430 V11A probably benign Het
Lrch1 G A 14: 74,786,342 T581M probably damaging Het
Mecom A G 3: 29,963,166 I450T probably damaging Het
Mrgprb2 C A 7: 48,552,564 V138L probably damaging Het
Muc15 G A 2: 110,731,596 A126T probably benign Het
Mybpc1 A T 10: 88,531,770 I522K probably damaging Het
Nectin1 G A 9: 43,792,147 R234H probably damaging Het
Olfr1450 T C 19: 12,954,042 F151S probably benign Het
Olfr190 A T 16: 59,074,267 I271K probably benign Het
Pdia6 T A 12: 17,274,422 H91Q possibly damaging Het
Pfkfb4 A T 9: 109,028,942 H445L probably damaging Het
Pkd1l1 T C 11: 8,961,336 T314A unknown Het
Rb1cc1 A G 1: 6,238,368 D159G probably damaging Het
Rhoh T A 5: 65,892,688 S100R probably benign Het
Rsbn1 T A 3: 103,961,500 D618E probably damaging Het
Slc25a47 T C 12: 108,851,190 V4A probably damaging Het
Thsd7a T C 6: 12,331,006 N1379S probably benign Het
Tmed3 T C 9: 89,704,753 D58G probably benign Het
Trh G A 6: 92,242,615 A240V probably benign Het
Ubox5 A T 2: 130,600,452 V105E probably benign Het
Vmn2r67 A G 7: 85,151,441 probably null Het
Vps13c A G 9: 67,930,643 H1825R probably benign Het
Wasf1 C A 10: 40,936,201 P329T unknown Het
Wee2 T C 6: 40,455,153 F219L probably damaging Het
Zp3r T C 1: 130,598,941 D175G probably damaging Het
Other mutations in Svs3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Svs3b APN 2 164256101 missense probably damaging 0.98
IGL01584:Svs3b APN 2 164256023 missense probably benign 0.35
IGL02279:Svs3b APN 2 164256204 missense possibly damaging 0.71
IGL03205:Svs3b APN 2 164256261 missense probably damaging 0.97
R0078:Svs3b UTSW 2 164255961 missense probably benign 0.14
R0097:Svs3b UTSW 2 164256239 missense probably damaging 0.98
R1920:Svs3b UTSW 2 164255928 missense probably benign 0.00
R1921:Svs3b UTSW 2 164255928 missense probably benign 0.00
R7938:Svs3b UTSW 2 164255647 nonsense probably null
R8118:Svs3b UTSW 2 164256006 missense probably damaging 0.97
R8209:Svs3b UTSW 2 164256220 missense possibly damaging 0.88
R8226:Svs3b UTSW 2 164256220 missense possibly damaging 0.88
Posted On2014-05-07