Incidental Mutation 'IGL01979:Wdr93'
ID181809
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wdr93
Ensembl Gene ENSMUSG00000039099
Gene NameWD repeat domain 93
SynonymsEG626359
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.062) question?
Stock #IGL01979
Quality Score
Status
Chromosome7
Chromosomal Location79743163-79785950 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 79776652 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Leucine at position 555 (Q555L)
Ref Sequence ENSEMBL: ENSMUSP00000037467 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035622]
Predicted Effect probably benign
Transcript: ENSMUST00000035622
AA Change: Q555L

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000037467
Gene: ENSMUSG00000039099
AA Change: Q555L

DomainStartEndE-ValueType
low complexity region 240 251 N/A INTRINSIC
low complexity region 265 274 N/A INTRINSIC
SCOP:d1jofa_ 389 607 7e-4 SMART
Blast:WD40 413 451 2e-11 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930435E12Rik A C 16: 38,827,893 S285A possibly damaging Het
Adh4 C T 3: 138,429,027 probably benign Het
Ap3b1 T A 13: 94,448,463 L394* probably null Het
Cdk2ap1 C T 5: 124,348,709 V57M probably damaging Het
Csnk2b T A 17: 35,118,016 N65I possibly damaging Het
Dennd4a G A 9: 64,894,409 E945K probably benign Het
Eif2b2 A G 12: 85,219,834 D59G probably benign Het
Ero1l A T 14: 45,287,744 N441K probably damaging Het
Fam91a1 A G 15: 58,432,584 D383G probably damaging Het
Fbxl7 C A 15: 26,789,563 S26I probably damaging Het
Il20 A T 1: 130,911,102 I42K probably damaging Het
Nav3 A G 10: 109,704,929 F1947L probably benign Het
Ncapd3 T A 9: 27,071,965 probably null Het
Numb G T 12: 83,842,277 H23N probably damaging Het
Olfr1419 G A 19: 11,871,223 probably benign Het
Olfr507 A G 7: 108,622,441 I210V probably benign Het
Ppp1r1b C T 11: 98,356,840 T111I probably damaging Het
Rad50 G A 11: 53,686,178 Q528* probably null Het
Scara3 A T 14: 65,930,963 S402T probably benign Het
Sept3 A G 15: 82,284,392 Y132C probably damaging Het
Sim2 C A 16: 94,123,482 N495K possibly damaging Het
Slc9b1 A G 3: 135,371,982 probably null Het
Tanc2 A G 11: 105,776,920 D109G probably benign Het
Traf1 T C 2: 34,943,893 I404V probably benign Het
Vmn2r68 C A 7: 85,222,117 V653L probably benign Het
Other mutations in Wdr93
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00928:Wdr93 APN 7 79775553 missense probably damaging 1.00
IGL01910:Wdr93 APN 7 79771573 missense probably damaging 1.00
IGL01977:Wdr93 APN 7 79752505 missense probably damaging 1.00
IGL02191:Wdr93 APN 7 79749220 missense probably damaging 0.98
R0008:Wdr93 UTSW 7 79758473 missense probably damaging 1.00
R0008:Wdr93 UTSW 7 79758473 missense probably damaging 1.00
R1136:Wdr93 UTSW 7 79773448 missense probably damaging 1.00
R1168:Wdr93 UTSW 7 79749174 missense probably damaging 0.99
R1586:Wdr93 UTSW 7 79768361 missense probably damaging 0.99
R1605:Wdr93 UTSW 7 79771509 splice site probably null
R1651:Wdr93 UTSW 7 79750082 missense probably benign 0.00
R3078:Wdr93 UTSW 7 79752493 missense possibly damaging 0.81
R3689:Wdr93 UTSW 7 79771585 missense possibly damaging 0.91
R4013:Wdr93 UTSW 7 79768411 missense possibly damaging 0.90
R4771:Wdr93 UTSW 7 79776763 missense probably damaging 0.99
R4824:Wdr93 UTSW 7 79750069 nonsense probably null
R4887:Wdr93 UTSW 7 79785774 missense probably damaging 1.00
R5172:Wdr93 UTSW 7 79752493 missense probably damaging 0.97
R5510:Wdr93 UTSW 7 79750031 missense probably damaging 1.00
R5625:Wdr93 UTSW 7 79771018 missense probably benign 0.00
R5648:Wdr93 UTSW 7 79777226 missense probably benign 0.04
R5950:Wdr93 UTSW 7 79773431 missense probably damaging 0.99
R6147:Wdr93 UTSW 7 79758497 missense probably benign
R6530:Wdr93 UTSW 7 79755993 missense probably damaging 1.00
R7056:Wdr93 UTSW 7 79749340 missense probably damaging 1.00
R7079:Wdr93 UTSW 7 79749292 missense probably damaging 1.00
R7309:Wdr93 UTSW 7 79773355 missense possibly damaging 0.86
R7397:Wdr93 UTSW 7 79766424 missense probably null 0.01
R7426:Wdr93 UTSW 7 79777307 critical splice donor site probably null
R7455:Wdr93 UTSW 7 79775519 missense probably benign 0.09
R7618:Wdr93 UTSW 7 79785726 missense probably benign 0.02
R8360:Wdr93 UTSW 7 79749226 missense probably damaging 0.99
Posted On2014-05-07