Incidental Mutation 'IGL01984:Dcun1d5'
ID181827
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dcun1d5
Ensembl Gene ENSMUSG00000032002
Gene NameDCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)
Synonyms
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.426) question?
Stock #IGL01984
Quality Score
Status
Chromosome9
Chromosomal Location7184520-7208205 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 7205307 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Asparagine at position 189 (Y189N)
Ref Sequence ENSEMBL: ENSMUSP00000150564 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034499] [ENSMUST00000215683]
Predicted Effect probably benign
Transcript: ENSMUST00000034499
SMART Domains Protein: ENSMUSP00000034499
Gene: ENSMUSG00000032002

DomainStartEndE-ValueType
low complexity region 3 24 N/A INTRINSIC
Pfam:Cullin_binding 120 231 1.3e-31 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215683
AA Change: Y189N

PolyPhen 2 Score 0.622 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect unknown
Transcript: ENSMUST00000215818
AA Change: Y75N
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216770
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933434E20Rik C T 3: 90,063,230 L24F probably benign Het
Adamts16 T C 13: 70,787,147 D442G probably damaging Het
Ankmy1 T C 1: 92,883,765 T634A probably damaging Het
Anxa3 A T 5: 96,834,771 probably benign Het
Ccnh T C 13: 85,206,151 L202P probably damaging Het
Clcn3 A T 8: 60,929,580 S325T probably damaging Het
Clec2d A T 6: 129,184,229 E96D possibly damaging Het
Csn1s1 A T 5: 87,676,510 probably benign Het
Dnah7a T C 1: 53,702,015 probably null Het
Erg T G 16: 95,409,927 D15A probably damaging Het
Gm11639 T A 11: 104,738,308 D937E probably benign Het
Gm17018 C T 19: 45,577,030 H148Y probably benign Het
Gm21759 T A 5: 8,180,547 probably benign Het
Heatr5b C T 17: 78,796,497 R1083Q possibly damaging Het
Ints3 A G 3: 90,392,226 S1012P possibly damaging Het
Klhl3 C T 13: 58,011,243 probably benign Het
Lama4 T A 10: 39,075,529 probably null Het
Magi1 A T 6: 93,708,174 V740D probably damaging Het
Nme8 C A 13: 19,688,980 V165L probably damaging Het
Odf2l G T 3: 145,139,829 E5* probably null Het
Olfr115 T C 17: 37,623,661 probably benign Het
Olfr1297 A G 2: 111,621,582 L164S probably benign Het
Olfr683 A T 7: 105,143,716 D192E probably benign Het
Pcnx4 T C 12: 72,574,409 V1001A probably benign Het
Plaa A G 4: 94,571,685 probably null Het
Prkdc G A 16: 15,708,779 A1305T probably benign Het
Rnps1 T C 17: 24,424,397 probably benign Het
St8sia5 T C 18: 77,248,461 F197L probably benign Het
Sult3a1 G T 10: 33,879,209 G257* probably null Het
Svep1 A C 4: 58,068,877 Y2970D possibly damaging Het
Tns3 G T 11: 8,548,992 Y30* probably null Het
Ubr1 G T 2: 120,921,386 P791T probably damaging Het
Zfp592 T C 7: 81,038,644 V1039A probably benign Het
Other mutations in Dcun1d5
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0103:Dcun1d5 UTSW 9 7188788 missense probably damaging 1.00
R0894:Dcun1d5 UTSW 9 7203379 splice site probably benign
R4943:Dcun1d5 UTSW 9 7186844 missense possibly damaging 0.86
R8489:Dcun1d5 UTSW 9 7206837 unclassified probably benign
Posted On2014-05-07