Incidental Mutation 'IGL01985:Tmem74'
ID181857
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem74
Ensembl Gene ENSMUSG00000054409
Gene Nametransmembrane protein 74
Synonyms
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01985
Quality Score
Status
Chromosome15
Chromosomal Location43864646-43870036 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 43867080 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Asparagine at position 189 (I189N)
Ref Sequence ENSEMBL: ENSMUSP00000070748 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067469]
Predicted Effect probably damaging
Transcript: ENSMUST00000067469
AA Change: I189N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000070748
Gene: ENSMUSG00000054409
AA Change: I189N

DomainStartEndE-ValueType
low complexity region 60 71 N/A INTRINSIC
Pfam:Neurensin 147 269 1.1e-12 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Cass4 A C 2: 172,427,206 S403R probably damaging Het
Ccdc175 A T 12: 72,128,278 Y540* probably null Het
Cep164 C T 9: 45,779,606 E1266K probably damaging Het
Clec12b T A 6: 129,382,371 probably benign Het
Col6a5 T C 9: 105,937,283 K510R unknown Het
Crisp4 G A 1: 18,134,065 P101S probably damaging Het
Dapk1 T C 13: 60,736,260 L614P probably damaging Het
Dip2c T C 13: 9,553,267 probably benign Het
Dock7 A G 4: 99,023,377 F589L probably benign Het
Dvl2 T A 11: 70,008,293 V459E probably damaging Het
E2f6 T C 12: 16,819,063 probably null Het
Exph5 T C 9: 53,376,569 L1650P probably damaging Het
Farp2 A G 1: 93,607,602 Y691C probably damaging Het
Fshb T C 2: 107,058,828 T44A probably benign Het
Gm13178 G A 4: 144,715,454 Q76* probably null Het
Gm28044 T A 13: 67,347,894 K28* probably null Het
Il12b G A 11: 44,408,054 W112* probably null Het
Ino80 T C 2: 119,433,321 T621A probably damaging Het
Irx5 T A 8: 92,359,527 probably benign Het
Jmy T C 13: 93,459,636 H495R possibly damaging Het
Kif21a A T 15: 90,991,767 V321D probably damaging Het
Lrrc10 T A 10: 117,046,016 D198E probably damaging Het
Lrsam1 T C 2: 32,928,091 E651G probably benign Het
Marc1 A G 1: 184,787,734 V230A probably damaging Het
Mylk4 T A 13: 32,717,581 I475L possibly damaging Het
Myom3 G A 4: 135,765,702 probably null Het
Olfr201 A T 16: 59,269,079 V196E probably benign Het
Pah G A 10: 87,578,982 V399M probably damaging Het
Pik3r4 G A 9: 105,663,045 E711K probably benign Het
Rbbp6 A G 7: 122,971,073 K38E probably damaging Het
Ror1 G A 4: 100,425,964 V409M possibly damaging Het
Slc6a11 T A 6: 114,134,892 V140D probably benign Het
Srebf2 G T 15: 82,192,359 A737S probably benign Het
Tcerg1 A G 18: 42,530,656 T303A unknown Het
Tnr A G 1: 159,919,037 D1242G possibly damaging Het
U2surp A T 9: 95,490,226 F293L probably damaging Het
Uchl5 G A 1: 143,786,126 probably benign Het
Usp34 T A 11: 23,452,565 C2472S probably damaging Het
Usp42 G A 5: 143,715,185 R1028W probably damaging Het
Vmn2r10 A G 5: 109,006,259 S60P probably benign Het
Vmn2r31 G T 7: 7,394,511 D249E probably benign Het
Vnn1 C T 10: 23,900,744 T331I probably benign Het
Zmym6 G T 4: 127,100,748 V232F probably damaging Het
Other mutations in Tmem74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01873:Tmem74 APN 15 43867386 missense probably benign 0.05
R1102:Tmem74 UTSW 15 43866790 missense probably benign 0.00
R1782:Tmem74 UTSW 15 43866952 missense probably damaging 1.00
R1851:Tmem74 UTSW 15 43867163 missense probably benign 0.29
R1852:Tmem74 UTSW 15 43867163 missense probably benign 0.29
R2352:Tmem74 UTSW 15 43867110 missense probably damaging 1.00
R3401:Tmem74 UTSW 15 43867021 missense probably damaging 1.00
R3402:Tmem74 UTSW 15 43867021 missense probably damaging 1.00
R3403:Tmem74 UTSW 15 43867021 missense probably damaging 1.00
R4095:Tmem74 UTSW 15 43867282 nonsense probably null
R4607:Tmem74 UTSW 15 43867158 missense probably damaging 0.98
R4608:Tmem74 UTSW 15 43867158 missense probably damaging 0.98
R5218:Tmem74 UTSW 15 43867244 missense possibly damaging 0.52
R5304:Tmem74 UTSW 15 43866821 nonsense probably null
R5375:Tmem74 UTSW 15 43867168 missense possibly damaging 0.77
R6074:Tmem74 UTSW 15 43866738 missense possibly damaging 0.77
R7264:Tmem74 UTSW 15 43867468 missense probably benign 0.00
R7485:Tmem74 UTSW 15 43867365 missense probably benign 0.01
Posted On2014-05-07