Incidental Mutation 'IGL01986:Rpa2'
ID 181896
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Rpa2
Ensembl Gene ENSMUSG00000028884
Gene Name replication protein A2
Synonyms RPA34, 30-kDa protein, Rf-A2
Accession Numbers
Essential gene? Probably essential (E-score: 0.960) question?
Stock # IGL01986
Quality Score
Status
Chromosome 4
Chromosomal Location 132495671-132506057 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 132499191 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 87 (P87S)
Ref Sequence ENSEMBL: ENSMUSP00000099621 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102561] [ENSMUST00000156968]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000102561
AA Change: P87S

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000099621
Gene: ENSMUSG00000028884
AA Change: P87S

DomainStartEndE-ValueType
low complexity region 8 21 N/A INTRINSIC
Pfam:RPA_C 166 262 1.7e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130090
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130444
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133415
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153046
Predicted Effect probably benign
Transcript: ENSMUST00000156968
SMART Domains Protein: ENSMUSP00000123780
Gene: ENSMUSG00000028884

DomainStartEndE-ValueType
Pfam:RPA_C 1 70 3.6e-17 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A T 2: 152,282,956 (GRCm39) I245F possibly damaging Het
Abca3 G A 17: 24,627,088 (GRCm39) G1263D probably damaging Het
Arap2 A T 5: 62,779,265 (GRCm39) S1442T probably damaging Het
Arl15 C A 13: 114,058,902 (GRCm39) S56R possibly damaging Het
Ccdc38 A T 10: 93,415,705 (GRCm39) N415Y probably damaging Het
Ccny G A 18: 9,377,817 (GRCm39) R81C probably damaging Het
Cracd T A 5: 77,006,457 (GRCm39) S939R unknown Het
Csmd3 T C 15: 47,522,591 (GRCm39) T2693A possibly damaging Het
Fancm C T 12: 65,173,429 (GRCm39) Q1914* probably null Het
Fcsk T C 8: 111,609,889 (GRCm39) T1042A probably benign Het
Gm18856 G A 13: 14,139,413 (GRCm39) probably benign Het
Gramd1a A T 7: 30,833,434 (GRCm39) L610Q possibly damaging Het
Hsd17b4 C A 18: 50,293,193 (GRCm39) probably benign Het
Hspa12a A G 19: 58,787,834 (GRCm39) S663P probably benign Het
Insr C T 8: 3,208,817 (GRCm39) V1215I probably damaging Het
Kdr A G 5: 76,113,519 (GRCm39) V783A probably benign Het
Klhl9 T C 4: 88,640,016 (GRCm39) D75G probably damaging Het
Lmntd1 A G 6: 145,365,533 (GRCm39) S53P probably damaging Het
Lrrc41 T A 4: 115,946,519 (GRCm39) F411L probably benign Het
Lyst G A 13: 13,950,212 (GRCm39) probably null Het
Mmp17 A G 5: 129,673,692 (GRCm39) H257R probably damaging Het
Nkiras1 G A 14: 18,280,071 (GRCm38) R154Q probably damaging Het
Or10ag2 A G 2: 87,248,880 (GRCm39) I163V probably benign Het
Or2b4 A G 17: 38,116,957 (GRCm39) K307R probably damaging Het
Or4p21 C T 2: 88,276,839 (GRCm39) V148I probably benign Het
Or8s16 T C 15: 98,210,660 (GRCm39) Y257C probably damaging Het
Pcsk6 G A 7: 65,577,625 (GRCm39) R60H probably damaging Het
Polk T C 13: 96,620,331 (GRCm39) D623G probably benign Het
Rlf A T 4: 121,005,303 (GRCm39) C1226S probably damaging Het
Sema5a T C 15: 32,682,506 (GRCm39) probably benign Het
Sis A T 3: 72,852,545 (GRCm39) M529K probably damaging Het
Sspo T C 6: 48,460,237 (GRCm39) M3375T probably benign Het
Syne3 A T 12: 104,934,259 (GRCm39) L83Q probably damaging Het
Tec A T 5: 72,939,348 (GRCm39) Y222* probably null Het
Tfap2d C T 1: 19,189,383 (GRCm39) probably benign Het
Trak1 G A 9: 121,302,033 (GRCm39) A930T probably benign Het
Ugt2b34 G T 5: 87,049,111 (GRCm39) H305N probably benign Het
Vmn2r95 A G 17: 18,660,473 (GRCm39) N295S probably benign Het
Other mutations in Rpa2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01986:Rpa2 APN 4 132,499,192 (GRCm39) missense probably benign 0.00
IGL03011:Rpa2 APN 4 132,502,358 (GRCm39) missense probably benign
R0062:Rpa2 UTSW 4 132,505,125 (GRCm39) missense probably damaging 1.00
R0062:Rpa2 UTSW 4 132,505,125 (GRCm39) missense probably damaging 1.00
R0094:Rpa2 UTSW 4 132,497,893 (GRCm39) missense probably damaging 1.00
R0094:Rpa2 UTSW 4 132,497,893 (GRCm39) missense probably damaging 1.00
R1168:Rpa2 UTSW 4 132,499,171 (GRCm39) missense probably damaging 1.00
R1812:Rpa2 UTSW 4 132,495,996 (GRCm39) missense probably benign 0.00
R2126:Rpa2 UTSW 4 132,496,099 (GRCm39) critical splice donor site probably null
R3051:Rpa2 UTSW 4 132,502,437 (GRCm39) splice site probably null
R4010:Rpa2 UTSW 4 132,497,960 (GRCm39) critical splice donor site probably null
R4223:Rpa2 UTSW 4 132,504,055 (GRCm39) missense probably damaging 1.00
R5175:Rpa2 UTSW 4 132,505,151 (GRCm39) missense probably damaging 1.00
R5406:Rpa2 UTSW 4 132,503,559 (GRCm39) missense probably benign 0.02
R6190:Rpa2 UTSW 4 132,502,331 (GRCm39) missense probably benign 0.13
R6413:Rpa2 UTSW 4 132,501,156 (GRCm39) missense probably benign 0.00
R7572:Rpa2 UTSW 4 132,496,014 (GRCm39) missense possibly damaging 0.94
R8503:Rpa2 UTSW 4 132,501,180 (GRCm39) missense probably benign 0.07
R8555:Rpa2 UTSW 4 132,499,481 (GRCm39) splice site probably null
R9021:Rpa2 UTSW 4 132,499,251 (GRCm39) missense probably damaging 1.00
R9024:Rpa2 UTSW 4 132,499,153 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07