Incidental Mutation 'IGL01986:Or8s16'
ID 181915
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8s16
Ensembl Gene ENSMUSG00000062037
Gene Name olfactory receptor family 8 subfamily S member 16
Synonyms GA_x6K02T2N22H-3824-2865, MOR160-3, Olfr257, GA_x6K02T2NBG7-5440777-5441736, Olfr285
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL01986
Quality Score
Status
Chromosome 15
Chromosomal Location 98210470-98211429 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98210660 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 257 (Y257C)
Ref Sequence ENSEMBL: ENSMUSP00000150788 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079736] [ENSMUST00000216901]
AlphaFold Q7TS17
Predicted Effect probably damaging
Transcript: ENSMUST00000079736
AA Change: Y257C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000078672
Gene: ENSMUSG00000062037
AA Change: Y257C

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 9.3e-47 PFAM
Pfam:7tm_1 39 286 5.9e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216901
AA Change: Y257C

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A T 2: 152,282,956 (GRCm39) I245F possibly damaging Het
Abca3 G A 17: 24,627,088 (GRCm39) G1263D probably damaging Het
Arap2 A T 5: 62,779,265 (GRCm39) S1442T probably damaging Het
Arl15 C A 13: 114,058,902 (GRCm39) S56R possibly damaging Het
Ccdc38 A T 10: 93,415,705 (GRCm39) N415Y probably damaging Het
Ccny G A 18: 9,377,817 (GRCm39) R81C probably damaging Het
Cracd T A 5: 77,006,457 (GRCm39) S939R unknown Het
Csmd3 T C 15: 47,522,591 (GRCm39) T2693A possibly damaging Het
Fancm C T 12: 65,173,429 (GRCm39) Q1914* probably null Het
Fcsk T C 8: 111,609,889 (GRCm39) T1042A probably benign Het
Gm18856 G A 13: 14,139,413 (GRCm39) probably benign Het
Gramd1a A T 7: 30,833,434 (GRCm39) L610Q possibly damaging Het
Hsd17b4 C A 18: 50,293,193 (GRCm39) probably benign Het
Hspa12a A G 19: 58,787,834 (GRCm39) S663P probably benign Het
Insr C T 8: 3,208,817 (GRCm39) V1215I probably damaging Het
Kdr A G 5: 76,113,519 (GRCm39) V783A probably benign Het
Klhl9 T C 4: 88,640,016 (GRCm39) D75G probably damaging Het
Lmntd1 A G 6: 145,365,533 (GRCm39) S53P probably damaging Het
Lrrc41 T A 4: 115,946,519 (GRCm39) F411L probably benign Het
Lyst G A 13: 13,950,212 (GRCm39) probably null Het
Mmp17 A G 5: 129,673,692 (GRCm39) H257R probably damaging Het
Nkiras1 G A 14: 18,280,071 (GRCm38) R154Q probably damaging Het
Or10ag2 A G 2: 87,248,880 (GRCm39) I163V probably benign Het
Or2b4 A G 17: 38,116,957 (GRCm39) K307R probably damaging Het
Or4p21 C T 2: 88,276,839 (GRCm39) V148I probably benign Het
Pcsk6 G A 7: 65,577,625 (GRCm39) R60H probably damaging Het
Polk T C 13: 96,620,331 (GRCm39) D623G probably benign Het
Rlf A T 4: 121,005,303 (GRCm39) C1226S probably damaging Het
Rpa2 C T 4: 132,499,191 (GRCm39) P87S probably benign Het
Rpa2 C T 4: 132,499,192 (GRCm39) P87L probably benign Het
Sema5a T C 15: 32,682,506 (GRCm39) probably benign Het
Sis A T 3: 72,852,545 (GRCm39) M529K probably damaging Het
Sspo T C 6: 48,460,237 (GRCm39) M3375T probably benign Het
Syne3 A T 12: 104,934,259 (GRCm39) L83Q probably damaging Het
Tec A T 5: 72,939,348 (GRCm39) Y222* probably null Het
Tfap2d C T 1: 19,189,383 (GRCm39) probably benign Het
Trak1 G A 9: 121,302,033 (GRCm39) A930T probably benign Het
Ugt2b34 G T 5: 87,049,111 (GRCm39) H305N probably benign Het
Vmn2r95 A G 17: 18,660,473 (GRCm39) N295S probably benign Het
Other mutations in Or8s16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02658:Or8s16 APN 15 98,211,237 (GRCm39) missense probably damaging 1.00
R1423:Or8s16 UTSW 15 98,211,324 (GRCm39) missense probably damaging 0.99
R1442:Or8s16 UTSW 15 98,211,068 (GRCm39) missense probably damaging 0.98
R1863:Or8s16 UTSW 15 98,211,372 (GRCm39) missense probably benign 0.02
R1938:Or8s16 UTSW 15 98,211,261 (GRCm39) missense probably damaging 1.00
R4815:Or8s16 UTSW 15 98,210,561 (GRCm39) missense probably damaging 1.00
R5248:Or8s16 UTSW 15 98,211,311 (GRCm39) missense probably damaging 1.00
R5879:Or8s16 UTSW 15 98,211,369 (GRCm39) missense probably benign 0.00
R6000:Or8s16 UTSW 15 98,211,317 (GRCm39) missense probably benign 0.08
R6371:Or8s16 UTSW 15 98,211,219 (GRCm39) missense possibly damaging 0.46
R7466:Or8s16 UTSW 15 98,211,261 (GRCm39) missense probably damaging 1.00
R7708:Or8s16 UTSW 15 98,211,029 (GRCm39) missense probably damaging 1.00
R8261:Or8s16 UTSW 15 98,210,546 (GRCm39) missense probably benign 0.00
R8734:Or8s16 UTSW 15 98,210,954 (GRCm39) missense probably damaging 1.00
R9462:Or8s16 UTSW 15 98,211,186 (GRCm39) missense possibly damaging 0.90
Posted On 2014-05-07