Incidental Mutation 'IGL01986:Lrrc41'
| ID |
181918 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Lrrc41
|
| Ensembl Gene |
ENSMUSG00000028703 |
| Gene Name |
leucine rich repeat containing 41 |
| Synonyms |
MUF1, D630045E04Rik, D730026A16Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.430)
|
| Stock # |
IGL01986
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
4 |
| Chromosomal Location |
115932466-115954240 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 115946519 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 411
(F411L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000030471
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030471]
|
| AlphaFold |
Q8K1C9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030471
AA Change: F411L
PolyPhen 2
Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000030471
Gene: ENSMUSG00000028703
AA Change: F411L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
30 |
45 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
291 |
N/A |
INTRINSIC |
|
low complexity region
|
314 |
325 |
N/A |
INTRINSIC |
|
low complexity region
|
352 |
382 |
N/A |
INTRINSIC |
|
low complexity region
|
417 |
429 |
N/A |
INTRINSIC |
|
SCOP:d1yrga_
|
449 |
742 |
4e-12 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000133799
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134983
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138952
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139147
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 6820408C15Rik |
A |
T |
2: 152,282,956 (GRCm39) |
I245F |
possibly damaging |
Het |
| Abca3 |
G |
A |
17: 24,627,088 (GRCm39) |
G1263D |
probably damaging |
Het |
| Arap2 |
A |
T |
5: 62,779,265 (GRCm39) |
S1442T |
probably damaging |
Het |
| Arl15 |
C |
A |
13: 114,058,902 (GRCm39) |
S56R |
possibly damaging |
Het |
| Ccdc38 |
A |
T |
10: 93,415,705 (GRCm39) |
N415Y |
probably damaging |
Het |
| Ccny |
G |
A |
18: 9,377,817 (GRCm39) |
R81C |
probably damaging |
Het |
| Cracd |
T |
A |
5: 77,006,457 (GRCm39) |
S939R |
unknown |
Het |
| Csmd3 |
T |
C |
15: 47,522,591 (GRCm39) |
T2693A |
possibly damaging |
Het |
| Fancm |
C |
T |
12: 65,173,429 (GRCm39) |
Q1914* |
probably null |
Het |
| Fcsk |
T |
C |
8: 111,609,889 (GRCm39) |
T1042A |
probably benign |
Het |
| Gm18856 |
G |
A |
13: 14,139,413 (GRCm39) |
|
probably benign |
Het |
| Gramd1a |
A |
T |
7: 30,833,434 (GRCm39) |
L610Q |
possibly damaging |
Het |
| Hsd17b4 |
C |
A |
18: 50,293,193 (GRCm39) |
|
probably benign |
Het |
| Hspa12a |
A |
G |
19: 58,787,834 (GRCm39) |
S663P |
probably benign |
Het |
| Insr |
C |
T |
8: 3,208,817 (GRCm39) |
V1215I |
probably damaging |
Het |
| Kdr |
A |
G |
5: 76,113,519 (GRCm39) |
V783A |
probably benign |
Het |
| Klhl9 |
T |
C |
4: 88,640,016 (GRCm39) |
D75G |
probably damaging |
Het |
| Lmntd1 |
A |
G |
6: 145,365,533 (GRCm39) |
S53P |
probably damaging |
Het |
| Lyst |
G |
A |
13: 13,950,212 (GRCm39) |
|
probably null |
Het |
| Mmp17 |
A |
G |
5: 129,673,692 (GRCm39) |
H257R |
probably damaging |
Het |
| Nkiras1 |
G |
A |
14: 18,280,071 (GRCm38) |
R154Q |
probably damaging |
Het |
| Or10ag2 |
A |
G |
2: 87,248,880 (GRCm39) |
I163V |
probably benign |
Het |
| Or2b4 |
A |
G |
17: 38,116,957 (GRCm39) |
K307R |
probably damaging |
Het |
| Or4p21 |
C |
T |
2: 88,276,839 (GRCm39) |
V148I |
probably benign |
Het |
| Or8s16 |
T |
C |
15: 98,210,660 (GRCm39) |
Y257C |
probably damaging |
Het |
| Pcsk6 |
G |
A |
7: 65,577,625 (GRCm39) |
R60H |
probably damaging |
Het |
| Polk |
T |
C |
13: 96,620,331 (GRCm39) |
D623G |
probably benign |
Het |
| Rlf |
A |
T |
4: 121,005,303 (GRCm39) |
C1226S |
probably damaging |
Het |
| Rpa2 |
C |
T |
4: 132,499,191 (GRCm39) |
P87S |
probably benign |
Het |
| Rpa2 |
C |
T |
4: 132,499,192 (GRCm39) |
P87L |
probably benign |
Het |
| Sema5a |
T |
C |
15: 32,682,506 (GRCm39) |
|
probably benign |
Het |
| Sis |
A |
T |
3: 72,852,545 (GRCm39) |
M529K |
probably damaging |
Het |
| Sspo |
T |
C |
6: 48,460,237 (GRCm39) |
M3375T |
probably benign |
Het |
| Syne3 |
A |
T |
12: 104,934,259 (GRCm39) |
L83Q |
probably damaging |
Het |
| Tec |
A |
T |
5: 72,939,348 (GRCm39) |
Y222* |
probably null |
Het |
| Tfap2d |
C |
T |
1: 19,189,383 (GRCm39) |
|
probably benign |
Het |
| Trak1 |
G |
A |
9: 121,302,033 (GRCm39) |
A930T |
probably benign |
Het |
| Ugt2b34 |
G |
T |
5: 87,049,111 (GRCm39) |
H305N |
probably benign |
Het |
| Vmn2r95 |
A |
G |
17: 18,660,473 (GRCm39) |
N295S |
probably benign |
Het |
|
| Other mutations in Lrrc41 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01309:Lrrc41
|
APN |
4 |
115,953,663 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01358:Lrrc41
|
APN |
4 |
115,932,784 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL01734:Lrrc41
|
APN |
4 |
115,950,331 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02159:Lrrc41
|
APN |
4 |
115,945,683 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02892:Lrrc41
|
APN |
4 |
115,946,032 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL03135:Lrrc41
|
APN |
4 |
115,945,728 (GRCm39) |
missense |
probably benign |
|
|
R1478:Lrrc41
|
UTSW |
4 |
115,952,405 (GRCm39) |
nonsense |
probably null |
|
|
R1765:Lrrc41
|
UTSW |
4 |
115,946,248 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2233:Lrrc41
|
UTSW |
4 |
115,953,582 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4080:Lrrc41
|
UTSW |
4 |
115,937,743 (GRCm39) |
splice site |
probably null |
|
|
R4677:Lrrc41
|
UTSW |
4 |
115,952,332 (GRCm39) |
missense |
probably benign |
|
|
R4833:Lrrc41
|
UTSW |
4 |
115,950,374 (GRCm39) |
unclassified |
probably benign |
|
|
R4877:Lrrc41
|
UTSW |
4 |
115,936,602 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4926:Lrrc41
|
UTSW |
4 |
115,946,521 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6459:Lrrc41
|
UTSW |
4 |
115,945,977 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6817:Lrrc41
|
UTSW |
4 |
115,946,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6834:Lrrc41
|
UTSW |
4 |
115,953,726 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7479:Lrrc41
|
UTSW |
4 |
115,946,238 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7512:Lrrc41
|
UTSW |
4 |
115,950,191 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7593:Lrrc41
|
UTSW |
4 |
115,950,141 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8006:Lrrc41
|
UTSW |
4 |
115,952,085 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8810:Lrrc41
|
UTSW |
4 |
115,932,488 (GRCm39) |
unclassified |
probably benign |
|
|
R9134:Lrrc41
|
UTSW |
4 |
115,945,782 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9495:Lrrc41
|
UTSW |
4 |
115,932,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
| Posted On |
2014-05-07 |
Incidental Mutation