Incidental Mutation 'IGL01987:Or7g18'
ID 181940
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7g18
Ensembl Gene ENSMUSG00000062868
Gene Name olfactory receptor family 7 subfamily G member 18
Synonyms GA_x6K02T2PVTD-12618399-12619337, Olfr830, MOR152-1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.122) question?
Stock # IGL01987
Quality Score
Status
Chromosome 9
Chromosomal Location 18786256-18787572 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 18787003 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 127 (I127L)
Ref Sequence ENSEMBL: ENSMUSP00000077903 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078861] [ENSMUST00000212723]
AlphaFold Q8VFJ5
Predicted Effect probably benign
Transcript: ENSMUST00000078861
AA Change: I127L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000077903
Gene: ENSMUSG00000062868
AA Change: I127L

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.8e-51 PFAM
Pfam:7tm_1 44 293 1.6e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212723
AA Change: I124L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A G 17: 24,565,202 (GRCm39) F77L probably benign Het
Abca8a A G 11: 109,964,981 (GRCm39) F439L possibly damaging Het
Abcb5 A T 12: 118,891,093 (GRCm39) V468D probably damaging Het
Adgrb3 A T 1: 25,140,512 (GRCm39) probably null Het
Ajm1 T C 2: 25,467,970 (GRCm39) E647G possibly damaging Het
Ankrd28 T C 14: 31,500,931 (GRCm39) D50G probably damaging Het
Cacna1b A T 2: 24,587,579 (GRCm39) probably null Het
Capn9 A G 8: 125,302,965 (GRCm39) S28G probably benign Het
Cdk5rap2 A G 4: 70,220,319 (GRCm39) probably null Het
Dmtf1l C T X: 125,722,098 (GRCm39) E336K possibly damaging Het
E2f5 T C 3: 14,652,363 (GRCm39) probably benign Het
Fam135b A G 15: 71,333,964 (GRCm39) Y1077H probably benign Het
Fap A G 2: 62,359,020 (GRCm39) Y428H probably damaging Het
Fasn A G 11: 120,708,899 (GRCm39) S595P probably damaging Het
Flnb T C 14: 7,922,748 (GRCm38) probably null Het
Fzd3 A T 14: 65,477,347 (GRCm39) V69E probably damaging Het
Gcdh A T 8: 85,620,110 (GRCm39) probably benign Het
Ido1 A G 8: 25,083,159 (GRCm39) Y89H probably benign Het
Itga2 G A 13: 114,984,482 (GRCm39) Q1010* probably null Het
Man1a2 T C 3: 100,551,873 (GRCm39) Y280C probably damaging Het
Mgat4d T C 8: 84,094,731 (GRCm39) I256T probably damaging Het
Mmrn1 A G 6: 60,921,557 (GRCm39) K5E probably benign Het
Ncapd2 A G 6: 125,162,804 (GRCm39) probably benign Het
Or2at4 A T 7: 99,384,478 (GRCm39) I43F probably damaging Het
Pcnx3 T C 19: 5,727,507 (GRCm39) D644G probably damaging Het
Pole T C 5: 110,485,098 (GRCm39) V2280A probably benign Het
Ptprf T A 4: 118,134,567 (GRCm39) M24L probably benign Het
Sbno1 T C 5: 124,542,282 (GRCm39) N337S probably damaging Het
Serpinc1 T A 1: 160,820,977 (GRCm39) F141L probably damaging Het
Shroom3 C A 5: 93,090,048 (GRCm39) R933S probably damaging Het
Slc24a2 G A 4: 87,146,033 (GRCm39) P7L probably benign Het
Slc25a32 G A 15: 38,961,002 (GRCm39) T227I probably damaging Het
Slc7a1 A G 5: 148,274,002 (GRCm39) F396L possibly damaging Het
Smok2a G A 17: 13,445,377 (GRCm39) R318H probably benign Het
Sntg2 A G 12: 30,362,569 (GRCm39) V59A probably damaging Het
Sspo A G 6: 48,454,558 (GRCm39) probably null Het
Tnfrsf1a G A 6: 125,333,827 (GRCm39) V27I probably damaging Het
Tnpo3 T C 6: 29,560,200 (GRCm39) T648A probably benign Het
Tpbg A G 9: 85,727,252 (GRCm39) Y407C probably damaging Het
Wbp2nl A T 15: 82,192,762 (GRCm39) M149L probably benign Het
Yif1a T A 19: 5,141,625 (GRCm39) M181K probably benign Het
Zkscan8 A G 13: 21,710,729 (GRCm39) L127S probably damaging Het
Other mutations in Or7g18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00932:Or7g18 APN 9 18,787,310 (GRCm39) nonsense probably null
IGL00954:Or7g18 APN 9 18,787,369 (GRCm39) missense probably benign 0.15
IGL01090:Or7g18 APN 9 18,787,538 (GRCm39) missense probably benign 0.00
IGL01613:Or7g18 APN 9 18,786,617 (GRCm39) splice site probably benign
IGL03018:Or7g18 APN 9 18,787,523 (GRCm39) missense probably benign 0.15
IGL03037:Or7g18 APN 9 18,786,668 (GRCm39) missense probably damaging 0.98
R0284:Or7g18 UTSW 9 18,786,848 (GRCm39) missense probably benign
R1322:Or7g18 UTSW 9 18,786,817 (GRCm39) missense possibly damaging 0.90
R1715:Or7g18 UTSW 9 18,787,090 (GRCm39) missense probably benign 0.06
R1803:Or7g18 UTSW 9 18,787,376 (GRCm39) missense probably damaging 1.00
R4360:Or7g18 UTSW 9 18,787,013 (GRCm39) missense probably damaging 1.00
R4394:Or7g18 UTSW 9 18,786,907 (GRCm39) missense probably damaging 0.98
R4642:Or7g18 UTSW 9 18,787,463 (GRCm39) missense probably damaging 1.00
R4796:Or7g18 UTSW 9 18,787,475 (GRCm39) missense probably damaging 0.96
R4814:Or7g18 UTSW 9 18,787,213 (GRCm39) missense probably benign 0.30
R5210:Or7g18 UTSW 9 18,787,103 (GRCm39) missense probably damaging 1.00
R5375:Or7g18 UTSW 9 18,787,442 (GRCm39) missense probably benign 0.08
R6072:Or7g18 UTSW 9 18,786,718 (GRCm39) missense probably benign
R6361:Or7g18 UTSW 9 18,787,027 (GRCm39) missense probably damaging 1.00
R6602:Or7g18 UTSW 9 18,787,145 (GRCm39) missense possibly damaging 0.81
R6920:Or7g18 UTSW 9 18,786,821 (GRCm39) missense probably damaging 1.00
R7730:Or7g18 UTSW 9 18,786,709 (GRCm39) missense probably benign 0.00
R7780:Or7g18 UTSW 9 18,786,910 (GRCm39) missense possibly damaging 0.65
R8245:Or7g18 UTSW 9 18,787,126 (GRCm39) missense probably benign
R8274:Or7g18 UTSW 9 18,786,795 (GRCm39) missense probably benign 0.36
R8920:Or7g18 UTSW 9 18,787,394 (GRCm39) missense probably damaging 1.00
R9564:Or7g18 UTSW 9 18,786,640 (GRCm39) missense probably benign 0.00
X0026:Or7g18 UTSW 9 18,786,931 (GRCm39) missense probably damaging 1.00
Posted On 2014-05-07