Incidental Mutation 'IGL01987:Ido1'
ID 181945
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ido1
Ensembl Gene ENSMUSG00000031551
Gene Name indoleamine 2,3-dioxygenase 1
Synonyms Ido, Indo
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01987
Quality Score
Status
Chromosome 8
Chromosomal Location 25074148-25086987 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 25083159 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 89 (Y89H)
Ref Sequence ENSEMBL: ENSMUSP00000033956 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000033956] [ENSMUST00000110667]
AlphaFold P28776
Predicted Effect probably benign
Transcript: ENSMUST00000033956
AA Change: Y89H

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000033956
Gene: ENSMUSG00000031551
AA Change: Y89H

DomainStartEndE-ValueType
Pfam:IDO 15 402 4.7e-124 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110667
SMART Domains Protein: ENSMUSP00000106295
Gene: ENSMUSG00000031551

DomainStartEndE-ValueType
Pfam:IDO 1 313 6e-111 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
PHENOTYPE: Mice homozygous for a null allele fail to induce IFN-alpha production by dendritic cells after B7 ligation, and show epididymal inflammation, teratospermia, and elevated caudal epididymal sperm counts along with higher protein and cytokine levels and reduced leukocyte count and proteasome activity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 A G 17: 24,565,202 (GRCm39) F77L probably benign Het
Abca8a A G 11: 109,964,981 (GRCm39) F439L possibly damaging Het
Abcb5 A T 12: 118,891,093 (GRCm39) V468D probably damaging Het
Adgrb3 A T 1: 25,140,512 (GRCm39) probably null Het
Ajm1 T C 2: 25,467,970 (GRCm39) E647G possibly damaging Het
Ankrd28 T C 14: 31,500,931 (GRCm39) D50G probably damaging Het
Cacna1b A T 2: 24,587,579 (GRCm39) probably null Het
Capn9 A G 8: 125,302,965 (GRCm39) S28G probably benign Het
Cdk5rap2 A G 4: 70,220,319 (GRCm39) probably null Het
Dmtf1l C T X: 125,722,098 (GRCm39) E336K possibly damaging Het
E2f5 T C 3: 14,652,363 (GRCm39) probably benign Het
Fam135b A G 15: 71,333,964 (GRCm39) Y1077H probably benign Het
Fap A G 2: 62,359,020 (GRCm39) Y428H probably damaging Het
Fasn A G 11: 120,708,899 (GRCm39) S595P probably damaging Het
Flnb T C 14: 7,922,748 (GRCm38) probably null Het
Fzd3 A T 14: 65,477,347 (GRCm39) V69E probably damaging Het
Gcdh A T 8: 85,620,110 (GRCm39) probably benign Het
Itga2 G A 13: 114,984,482 (GRCm39) Q1010* probably null Het
Man1a2 T C 3: 100,551,873 (GRCm39) Y280C probably damaging Het
Mgat4d T C 8: 84,094,731 (GRCm39) I256T probably damaging Het
Mmrn1 A G 6: 60,921,557 (GRCm39) K5E probably benign Het
Ncapd2 A G 6: 125,162,804 (GRCm39) probably benign Het
Or2at4 A T 7: 99,384,478 (GRCm39) I43F probably damaging Het
Or7g18 A T 9: 18,787,003 (GRCm39) I127L probably benign Het
Pcnx3 T C 19: 5,727,507 (GRCm39) D644G probably damaging Het
Pole T C 5: 110,485,098 (GRCm39) V2280A probably benign Het
Ptprf T A 4: 118,134,567 (GRCm39) M24L probably benign Het
Sbno1 T C 5: 124,542,282 (GRCm39) N337S probably damaging Het
Serpinc1 T A 1: 160,820,977 (GRCm39) F141L probably damaging Het
Shroom3 C A 5: 93,090,048 (GRCm39) R933S probably damaging Het
Slc24a2 G A 4: 87,146,033 (GRCm39) P7L probably benign Het
Slc25a32 G A 15: 38,961,002 (GRCm39) T227I probably damaging Het
Slc7a1 A G 5: 148,274,002 (GRCm39) F396L possibly damaging Het
Smok2a G A 17: 13,445,377 (GRCm39) R318H probably benign Het
Sntg2 A G 12: 30,362,569 (GRCm39) V59A probably damaging Het
Sspo A G 6: 48,454,558 (GRCm39) probably null Het
Tnfrsf1a G A 6: 125,333,827 (GRCm39) V27I probably damaging Het
Tnpo3 T C 6: 29,560,200 (GRCm39) T648A probably benign Het
Tpbg A G 9: 85,727,252 (GRCm39) Y407C probably damaging Het
Wbp2nl A T 15: 82,192,762 (GRCm39) M149L probably benign Het
Yif1a T A 19: 5,141,625 (GRCm39) M181K probably benign Het
Zkscan8 A G 13: 21,710,729 (GRCm39) L127S probably damaging Het
Other mutations in Ido1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Ido1 APN 8 25,074,575 (GRCm39) missense possibly damaging 0.93
IGL02960:Ido1 APN 8 25,083,345 (GRCm39) splice site probably benign
R0180:Ido1 UTSW 8 25,083,156 (GRCm39) missense possibly damaging 0.87
R0652:Ido1 UTSW 8 25,075,260 (GRCm39) missense probably damaging 1.00
R1102:Ido1 UTSW 8 25,083,156 (GRCm39) missense probably damaging 1.00
R1474:Ido1 UTSW 8 25,074,462 (GRCm39) missense probably damaging 0.97
R1925:Ido1 UTSW 8 25,075,306 (GRCm39) missense possibly damaging 0.82
R2509:Ido1 UTSW 8 25,074,501 (GRCm39) nonsense probably null
R4913:Ido1 UTSW 8 25,074,533 (GRCm39) missense probably benign
R4962:Ido1 UTSW 8 25,074,565 (GRCm39) missense probably benign 0.00
R5313:Ido1 UTSW 8 25,077,794 (GRCm39) missense probably damaging 1.00
R5654:Ido1 UTSW 8 25,077,819 (GRCm39) missense probably damaging 1.00
R5660:Ido1 UTSW 8 25,081,558 (GRCm39) missense probably damaging 1.00
R6144:Ido1 UTSW 8 25,075,306 (GRCm39) missense possibly damaging 0.82
R7436:Ido1 UTSW 8 25,076,932 (GRCm39) missense probably benign 0.00
R7615:Ido1 UTSW 8 25,083,204 (GRCm39) missense probably damaging 1.00
R7873:Ido1 UTSW 8 25,074,758 (GRCm39) missense probably damaging 0.98
R8490:Ido1 UTSW 8 25,086,954 (GRCm39) start codon destroyed probably null 1.00
R8896:Ido1 UTSW 8 25,077,880 (GRCm39) missense probably benign 0.00
R8917:Ido1 UTSW 8 25,081,523 (GRCm39) missense probably benign
R9361:Ido1 UTSW 8 25,079,601 (GRCm39) missense probably benign 0.01
Posted On 2014-05-07