Incidental Mutation 'IGL01987:Yif1a'
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ID181951
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Yif1a
Ensembl Gene ENSMUSG00000024875
Gene NameYip1 interacting factor homolog A (S. cerevisiae)
Synonyms5330422J23Rik, Yif1p, 54TM
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.241) question?
Stock #IGL01987
Quality Score
Status
Chromosome19
Chromosomal Location5088538-5092879 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 5091597 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 181 (M181K)
Ref Sequence ENSEMBL: ENSMUSP00000025811 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025805] [ENSMUST00000025811]
Predicted Effect probably benign
Transcript: ENSMUST00000025805
SMART Domains Protein: ENSMUSP00000025805
Gene: ENSMUSG00000024873

DomainStartEndE-ValueType
Pfam:Cornichon 7 151 5.3e-37 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000025811
AA Change: M181K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000025811
Gene: ENSMUSG00000024875
AA Change: M181K

DomainStartEndE-ValueType
Pfam:YIF1 57 286 8.3e-84 PFAM
Pfam:Yip1 113 255 9.5e-14 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932411N23Rik C T X: 126,814,475 E336K possibly damaging Het
Abca17 A G 17: 24,346,228 F77L probably benign Het
Abca8a A G 11: 110,074,155 F439L possibly damaging Het
Abcb5 A T 12: 118,927,358 V468D probably damaging Het
Adgrb3 A T 1: 25,101,431 probably null Het
Ankrd28 T C 14: 31,778,974 D50G probably damaging Het
Cacna1b A T 2: 24,697,567 probably null Het
Capn9 A G 8: 124,576,226 S28G probably benign Het
Cdk5rap2 A G 4: 70,302,082 probably null Het
E2f5 T C 3: 14,587,303 probably benign Het
Fam135b A G 15: 71,462,115 Y1077H probably benign Het
Fap A G 2: 62,528,676 Y428H probably damaging Het
Fasn A G 11: 120,818,073 S595P probably damaging Het
Flnb T C 14: 7,922,748 probably null Het
Fzd3 A T 14: 65,239,898 V69E probably damaging Het
Gcdh A T 8: 84,893,481 probably benign Het
Gm996 T C 2: 25,577,958 E647G possibly damaging Het
Ido1 A G 8: 24,593,143 Y89H probably benign Het
Itga2 G A 13: 114,847,946 Q1010* probably null Het
Man1a2 T C 3: 100,644,557 Y280C probably damaging Het
Mgat4d T C 8: 83,368,102 I256T probably damaging Het
Mmrn1 A G 6: 60,944,573 K5E probably benign Het
Ncapd2 A G 6: 125,185,841 probably benign Het
Olfr520 A T 7: 99,735,271 I43F probably damaging Het
Olfr830 A T 9: 18,875,707 I127L probably benign Het
Pcnx3 T C 19: 5,677,479 D644G probably damaging Het
Pole T C 5: 110,337,232 V2280A probably benign Het
Ptprf T A 4: 118,277,370 M24L probably benign Het
Sbno1 T C 5: 124,404,219 N337S probably damaging Het
Serpinc1 T A 1: 160,993,407 F141L probably damaging Het
Shroom3 C A 5: 92,942,189 R933S probably damaging Het
Slc24a2 G A 4: 87,227,796 P7L probably benign Het
Slc25a32 G A 15: 39,097,607 T227I probably damaging Het
Slc7a1 A G 5: 148,337,192 F396L possibly damaging Het
Smok2a G A 17: 13,226,490 R318H probably benign Het
Sntg2 A G 12: 30,312,570 V59A probably damaging Het
Sspo A G 6: 48,477,624 probably null Het
Tnfrsf1a G A 6: 125,356,864 V27I probably damaging Het
Tnpo3 T C 6: 29,560,201 T648A probably benign Het
Tpbg A G 9: 85,845,199 Y407C probably damaging Het
Wbp2nl A T 15: 82,308,561 M149L probably benign Het
Zkscan8 A G 13: 21,526,559 L127S probably damaging Het
Other mutations in Yif1a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03067:Yif1a APN 19 5089785 missense possibly damaging 0.77
IGL03070:Yif1a APN 19 5088729 missense possibly damaging 0.51
R1817:Yif1a UTSW 19 5092305 nonsense probably null
R2027:Yif1a UTSW 19 5089872 missense probably damaging 1.00
R5639:Yif1a UTSW 19 5088750 critical splice donor site probably null
R5942:Yif1a UTSW 19 5091641 missense probably damaging 1.00
R6360:Yif1a UTSW 19 5092341 missense probably benign
R6524:Yif1a UTSW 19 5092176 missense probably damaging 1.00
R7378:Yif1a UTSW 19 5089790 missense possibly damaging 0.83
R7976:Yif1a UTSW 19 5089787 missense probably damaging 1.00
Z1177:Yif1a UTSW 19 5091587 frame shift probably null
Posted On2014-05-07