Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01988:Nedd1'

182006

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nedd1

Ensembl Gene

ENSMUSG00000019988

Gene Name

neural precursor cell expressed, developmentally down-regulated gene 1

Synonyms

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.966) question?

Stock #

IGL01988

Quality Score

Status

Chromosome

Chromosomal Location

92684746-92722420 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 92714159 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Lysine at position 88 (T88K)

Ref Sequence

ENSEMBL: ENSMUSP00000020163 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000020163] [ENSMUST00000216086]

AlphaFold

P33215

Predicted Effect

probably benign
Transcript: ENSMUST00000020163
AA Change: T88K

PolyPhen 2 Score 0.394 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000020163
Gene: ENSMUSG00000019988
AA Change: T88K

Domain	Start	End	E-Value	Type
WD40	21	63	5.97e-1	SMART
WD40	67	105	9.75e-3	SMART
WD40	108	147	6.19e-5	SMART
WD40	149	191	6.42e-1	SMART
WD40	194	235	9.1e-3	SMART
WD40	238	276	2.24e-2	SMART
low complexity region	555	568	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000213901

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214417

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215970

Predicted Effect

probably benign
Transcript: ENSMUST00000216086

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9330159F19Rik	T	A	10: 29,225,111	S493R	probably benign	Het
Abca17	T	C	17: 24,334,255	N161D	probably damaging	Het
Ace2	C	A	X: 164,163,992	N290K	possibly damaging	Het
Adam26a	G	A	8: 43,569,170	P428S	possibly damaging	Het
Adgrv1	T	C	13: 81,557,309	R1461G	probably damaging	Het
Arhgef10l	T	C	4: 140,578,361		probably benign	Het
Bicc1	A	G	10: 70,956,176	V334A	probably damaging	Het
C8a	T	C	4: 104,826,694	Y408C	probably damaging	Het
Col24a1	T	C	3: 145,524,167		probably null	Het
Copa	T	A	1: 172,118,264	N931K	probably benign	Het
Cr1l	A	G	1: 195,117,550	M272T	probably damaging	Het
Dcaf12	T	C	4: 41,298,299	N283S	probably benign	Het
Dnttip2	T	A	3: 122,276,295	S386R	probably benign	Het
Fbll1	G	T	11: 35,797,901	D178E	probably benign	Het
Fgd6	A	G	10: 94,074,335		probably benign	Het
Fyn	T	A	10: 39,533,921	L408*	probably null	Het
Gkn2	T	C	6: 87,379,275	V176A	probably benign	Het
Gm10764	G	A	10: 87,291,091	C120Y	unknown	Het
Gpr19	A	T	6: 134,869,284	F442I	probably damaging	Het
Herc1	A	G	9: 66,488,075		probably benign	Het
Il7	A	G	3: 7,604,066	Y37H	possibly damaging	Het
Kcnj3	G	A	2: 55,437,231	D11N	probably benign	Het
Kif1c	A	G	11: 70,704,936	D156G	probably damaging	Het
Lrch1	T	C	14: 74,795,373		probably benign	Het
Nlrc3	T	G	16: 3,953,939	S875R	probably benign	Het
Olfr1251	T	A	2: 89,667,080	I269F	probably benign	Het
Optc	A	G	1: 133,906,929		probably null	Het
Pcdh17	T	A	14: 84,446,622	D176E	probably damaging	Het
Pde1b	A	G	15: 103,524,856		probably null	Het
Phf11a	A	T	14: 59,277,358	D291E	probably damaging	Het
Slc30a8	A	T	15: 52,335,205	I349L	probably benign	Het
Spty2d1	T	A	7: 46,997,610	S524C	probably damaging	Het
Syndig1	T	C	2: 150,003,170		probably benign	Het
Syvn1	G	A	19: 6,052,407	A502T	probably benign	Het
Tenm2	A	G	11: 36,027,251	L1894P	probably damaging	Het
Tmem176a	T	A	6: 48,842,620	V11E	possibly damaging	Het
Tpr	G	T	1: 150,426,999		probably null	Het
Txnrd2	T	C	16: 18,456,018		probably benign	Het
Ubqln3	G	A	7: 104,142,882		probably benign	Het
Vmn1r6	C	T	6: 57,002,665	T82I	probably damaging	Het
Wdfy4	C	T	14: 33,076,480	E1990K	possibly damaging	Het
Zdhhc7	T	C	8: 120,082,590	R293G	probably benign	Het
Zeb1	T	A	18: 5,759,037	L148*	probably null	Het

Other mutations in Nedd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00764:Nedd1	APN	10	92694974	splice site	probably benign
IGL00988:Nedd1	APN	10	92689686	missense	possibly damaging	0.71
IGL01563:Nedd1	APN	10	92698169	critical splice donor site	probably null
IGL01588:Nedd1	APN	10	92686262	missense	probably benign	0.12
IGL02706:Nedd1	APN	10	92686285	missense	possibly damaging	0.88
IGL02938:Nedd1	APN	10	92689657	nonsense	probably null
IGL03011:Nedd1	APN	10	92689641	missense	possibly damaging	0.92
Brainless	UTSW	10	92690773	missense	probably benign	0.01
R0125:Nedd1	UTSW	10	92691929	missense	possibly damaging	0.93
R0173:Nedd1	UTSW	10	92698883	missense	probably benign	0.30
R0244:Nedd1	UTSW	10	92716265	intron	probably benign
R0645:Nedd1	UTSW	10	92691831	splice site	probably null
R0791:Nedd1	UTSW	10	92719614	missense	probably damaging	1.00
R1490:Nedd1	UTSW	10	92700798	missense	probably damaging	1.00
R1522:Nedd1	UTSW	10	92719614	missense	probably damaging	1.00
R1797:Nedd1	UTSW	10	92698739	missense	possibly damaging	0.46
R1984:Nedd1	UTSW	10	92714160	missense	possibly damaging	0.63
R2474:Nedd1	UTSW	10	92719603	missense	probably damaging	0.99
R2877:Nedd1	UTSW	10	92714126	missense	possibly damaging	0.89
R2883:Nedd1	UTSW	10	92694998	missense	probably damaging	0.98
R4694:Nedd1	UTSW	10	92719582	missense	probably benign	0.00
R4798:Nedd1	UTSW	10	92698910	missense	probably benign	0.00
R4830:Nedd1	UTSW	10	92686258	missense	probably damaging	1.00
R4963:Nedd1	UTSW	10	92695031	missense	probably damaging	1.00
R5174:Nedd1	UTSW	10	92711212	missense	possibly damaging	0.77
R5329:Nedd1	UTSW	10	92686240	missense	probably damaging	1.00
R5404:Nedd1	UTSW	10	92716192	missense	probably benign	0.04
R5534:Nedd1	UTSW	10	92695032	missense	probably benign	0.01
R6045:Nedd1	UTSW	10	92695100	nonsense	probably null
R6154:Nedd1	UTSW	10	92698242	missense	possibly damaging	0.65
R6512:Nedd1	UTSW	10	92691875	missense	probably benign
R6692:Nedd1	UTSW	10	92698337	missense	possibly damaging	0.88
R6693:Nedd1	UTSW	10	92698337	missense	possibly damaging	0.88
R6943:Nedd1	UTSW	10	92711306	missense	probably damaging	1.00
R7011:Nedd1	UTSW	10	92690773	missense	probably benign	0.01
R7406:Nedd1	UTSW	10	92711323	splice site	probably null
R7455:Nedd1	UTSW	10	92700925	missense	probably benign	0.01
R7587:Nedd1	UTSW	10	92698730	missense	probably benign	0.01
R7745:Nedd1	UTSW	10	92714172	missense	probably benign
R8104:Nedd1	UTSW	10	92691916	missense	probably damaging	1.00
R8209:Nedd1	UTSW	10	92691935	missense	probably benign
R8226:Nedd1	UTSW	10	92691935	missense	probably benign
R8925:Nedd1	UTSW	10	92722396	start gained	probably benign
R8927:Nedd1	UTSW	10	92722396	start gained	probably benign

Posted On

2014-05-07