Incidental Mutation 'IGL01997:Gnat3'
ID 182103
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gnat3
Ensembl Gene ENSMUSG00000028777
Gene Name G protein subunit alpha transducin 3
Synonyms Gtn, Ggust, alpha-gustducin
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01997
Quality Score
Status
Chromosome 5
Chromosomal Location 18167568-18224666 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 18204721 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 125 (E125*)
Ref Sequence ENSEMBL: ENSMUSP00000030561 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030561]
AlphaFold Q3V3I2
Predicted Effect probably null
Transcript: ENSMUST00000030561
AA Change: E125*
SMART Domains Protein: ENSMUSP00000030561
Gene: ENSMUSG00000028777
AA Change: E125*

DomainStartEndE-ValueType
G_alpha 13 353 3.06e-221 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Sweet, bitter, and umami tastes are transmitted from taste receptors by a specific guanine nucleotide binding protein. The protein encoded by this gene is the alpha subunit of this heterotrimeric G protein, which is found not only in the oral epithelium but also in gut tissues. Variations in this gene have been linked to metabolic syndrome. [provided by RefSeq, Dec 2015]
PHENOTYPE: Homozygous mutation of this gene results in abnormal taste sensitivity. Mice show reduced behavioral and electrophysiological responses to bitter, sweet, and unami compounds. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 G A 1: 179,583,027 (GRCm39) T83I probably damaging Het
Aoah A T 13: 21,184,108 (GRCm39) M391L probably benign Het
Apc A G 18: 34,448,476 (GRCm39) T1757A probably benign Het
B4galt5 A G 2: 167,143,261 (GRCm39) Y388H probably benign Het
Cyp3a25 A T 5: 145,931,766 (GRCm39) M114K possibly damaging Het
Dcbld1 A G 10: 52,193,206 (GRCm39) E246G probably damaging Het
Fstl4 T A 11: 53,053,881 (GRCm39) Y404* probably null Het
Hspa5 C T 2: 34,662,327 (GRCm39) probably benign Het
Krt72 A G 15: 101,693,315 (GRCm39) S200P probably damaging Het
Mab21l3 G A 3: 101,725,955 (GRCm39) T347I probably damaging Het
Map2k7 A G 8: 4,293,442 (GRCm39) E104G probably benign Het
Map3k9 T C 12: 81,819,471 (GRCm39) D261G probably damaging Het
Mepe C T 5: 104,485,466 (GRCm39) P202L probably damaging Het
Mill1 G A 7: 17,989,814 (GRCm39) G32D probably damaging Het
Mmp20 T G 9: 7,639,261 (GRCm39) M143R probably benign Het
Mms19 A T 19: 41,944,970 (GRCm39) L302H probably damaging Het
Myh13 T A 11: 67,257,992 (GRCm39) I1728K probably benign Het
Nsun2 C T 13: 69,771,365 (GRCm39) P290L probably damaging Het
Nwd2 A T 5: 63,961,938 (GRCm39) R507S probably damaging Het
Os9 T A 10: 126,955,312 (GRCm39) H147L probably benign Het
Piezo1 T C 8: 123,215,070 (GRCm39) probably benign Het
Plekhf1 A T 7: 37,920,752 (GRCm39) V272D probably damaging Het
Pnisr T C 4: 21,871,537 (GRCm39) I419T possibly damaging Het
Ppp1r3d G T 2: 178,055,447 (GRCm39) T185K possibly damaging Het
Ppp2r2a C T 14: 67,253,968 (GRCm39) S400N probably benign Het
Rpl21 T C 5: 146,772,418 (GRCm39) I96T probably benign Het
S1pr3 C T 13: 51,573,751 (GRCm39) R311W probably damaging Het
Senp5 T C 16: 31,782,288 (GRCm39) K736R probably damaging Het
Slfn9 T C 11: 82,878,503 (GRCm39) I209V possibly damaging Het
Traf3ip1 T A 1: 91,435,292 (GRCm39) probably null Het
Tyk2 A G 9: 21,021,790 (GRCm39) F879L probably damaging Het
Vmn2r53 T C 7: 12,316,373 (GRCm39) D482G possibly damaging Het
Vmn2r65 A G 7: 84,589,978 (GRCm39) F646S probably damaging Het
Vps13b T A 15: 35,709,370 (GRCm39) S1772R probably damaging Het
Vwde C T 6: 13,215,705 (GRCm39) C117Y probably damaging Het
Zfyve26 T C 12: 79,291,174 (GRCm39) I2144V probably benign Het
Other mutations in Gnat3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00941:Gnat3 APN 5 18,208,749 (GRCm39) splice site probably benign
IGL01023:Gnat3 APN 5 18,208,826 (GRCm39) missense probably damaging 1.00
PIT4377001:Gnat3 UTSW 5 18,220,557 (GRCm39) missense
R0556:Gnat3 UTSW 5 18,224,596 (GRCm39) missense probably damaging 1.00
R1624:Gnat3 UTSW 5 18,208,841 (GRCm39) missense possibly damaging 0.66
R1934:Gnat3 UTSW 5 18,224,508 (GRCm39) missense possibly damaging 0.74
R2319:Gnat3 UTSW 5 18,224,624 (GRCm39) missense probably benign 0.17
R3928:Gnat3 UTSW 5 18,208,892 (GRCm39) splice site probably benign
R4169:Gnat3 UTSW 5 18,208,862 (GRCm39) missense probably damaging 1.00
R4420:Gnat3 UTSW 5 18,204,799 (GRCm39) missense probably damaging 1.00
R4632:Gnat3 UTSW 5 18,220,364 (GRCm39) splice site probably null
R4651:Gnat3 UTSW 5 18,220,568 (GRCm39) missense probably damaging 1.00
R4652:Gnat3 UTSW 5 18,220,568 (GRCm39) missense probably damaging 1.00
R5471:Gnat3 UTSW 5 18,196,322 (GRCm39) missense probably damaging 1.00
R7460:Gnat3 UTSW 5 18,204,656 (GRCm39) missense
R7627:Gnat3 UTSW 5 18,204,746 (GRCm39) missense
R7637:Gnat3 UTSW 5 18,208,770 (GRCm39) missense
R8342:Gnat3 UTSW 5 18,208,838 (GRCm39) missense
R8428:Gnat3 UTSW 5 18,220,312 (GRCm39) missense possibly damaging 0.89
X0064:Gnat3 UTSW 5 18,208,838 (GRCm39) missense possibly damaging 0.74
Z1088:Gnat3 UTSW 5 18,220,321 (GRCm39) missense probably damaging 1.00
Z1177:Gnat3 UTSW 5 18,220,311 (GRCm39) nonsense probably null
Posted On 2014-05-07