Incidental Mutation 'IGL02007:Zfp663'
ID 182247
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp663
Ensembl Gene ENSMUSG00000056824
Gene Name zinc finger protein 663
Synonyms LOC381405, Gm1008
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL02007
Quality Score
Status
Chromosome 2
Chromosomal Location 165193217-165210649 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 165200993 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 14 (S14A)
Ref Sequence ENSEMBL: ENSMUSP00000099374 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073062] [ENSMUST00000103085] [ENSMUST00000141140]
AlphaFold Q6NXM6
Predicted Effect probably benign
Transcript: ENSMUST00000073062
AA Change: S14A

PolyPhen 2 Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000072813
Gene: ENSMUSG00000056824
AA Change: S14A

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
ZnF_C2H2 205 227 3.47e1 SMART
ZnF_C2H2 472 494 2.4e-3 SMART
ZnF_C2H2 500 522 2.99e-4 SMART
ZnF_C2H2 528 550 2.43e-4 SMART
ZnF_C2H2 556 578 4.79e-3 SMART
ZnF_C2H2 584 606 3.95e-4 SMART
ZnF_C2H2 612 635 8.6e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000103085
AA Change: S14A

PolyPhen 2 Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000099374
Gene: ENSMUSG00000056824
AA Change: S14A

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
ZnF_C2H2 205 227 3.47e1 SMART
ZnF_C2H2 472 494 2.4e-3 SMART
ZnF_C2H2 500 522 2.99e-4 SMART
ZnF_C2H2 528 550 2.43e-4 SMART
ZnF_C2H2 556 578 4.79e-3 SMART
ZnF_C2H2 584 606 3.95e-4 SMART
ZnF_C2H2 612 635 8.6e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136482
Predicted Effect probably benign
Transcript: ENSMUST00000141140
AA Change: S14A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000115254
Gene: ENSMUSG00000056824
AA Change: S14A

DomainStartEndE-ValueType
KRAB 8 68 1.97e-31 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam28 C A 14: 68,870,668 (GRCm39) R335L possibly damaging Het
Adgrv1 T C 13: 81,716,862 (GRCm39) probably benign Het
Calcrl A G 2: 84,205,668 (GRCm39) C8R probably benign Het
Cntn4 T A 6: 106,632,490 (GRCm39) S505T probably benign Het
Cyp3a16 T C 5: 145,378,758 (GRCm39) probably benign Het
Dync2i2 A G 2: 29,928,402 (GRCm39) S75P probably benign Het
Fhip1a G T 3: 85,629,752 (GRCm39) P280T probably damaging Het
Gpatch11 A G 17: 79,149,593 (GRCm39) T198A probably benign Het
H2-T15 G T 17: 36,367,222 (GRCm39) N333K possibly damaging Het
Heatr5a C A 12: 51,962,941 (GRCm39) L986F probably damaging Het
Ift172 A G 5: 31,443,948 (GRCm39) I90T probably benign Het
Igkv3-9 A G 6: 70,565,445 (GRCm39) probably benign Het
Iqsec1 G A 6: 90,667,331 (GRCm39) P369S probably benign Het
Myh1 C A 11: 67,111,382 (GRCm39) T1607K probably benign Het
Myo18b T C 5: 113,022,838 (GRCm39) probably benign Het
Nobox A G 6: 43,284,472 (GRCm39) L58P probably damaging Het
Nwd2 T A 5: 63,962,042 (GRCm39) I542N possibly damaging Het
Or4k51 A G 2: 111,584,824 (GRCm39) T77A probably damaging Het
Or5p54 A G 7: 107,553,953 (GRCm39) Y35C probably damaging Het
Osm C T 11: 4,189,470 (GRCm39) R85W probably damaging Het
Pcdh20 T C 14: 88,707,031 (GRCm39) R90G probably benign Het
Pkhd1l1 T C 15: 44,397,129 (GRCm39) probably benign Het
Sec14l2 A G 11: 4,061,114 (GRCm39) S116P probably benign Het
Selenbp2 A C 3: 94,605,461 (GRCm39) N96H possibly damaging Het
Smarcal1 T C 1: 72,635,099 (GRCm39) S393P probably damaging Het
Tbc1d1 A G 5: 64,414,335 (GRCm39) Q103R probably damaging Het
Tmem63c T C 12: 87,119,647 (GRCm39) Y314H probably damaging Het
Zmynd10 A G 9: 107,427,731 (GRCm39) N345S probably damaging Het
Other mutations in Zfp663
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00720:Zfp663 APN 2 165,194,525 (GRCm39) missense probably damaging 1.00
IGL01382:Zfp663 APN 2 165,200,935 (GRCm39) missense probably damaging 1.00
IGL02164:Zfp663 APN 2 165,200,968 (GRCm39) nonsense probably null
IGL02506:Zfp663 APN 2 165,195,871 (GRCm39) missense probably benign 0.35
IGL03173:Zfp663 APN 2 165,194,419 (GRCm39) missense probably damaging 0.99
R0735:Zfp663 UTSW 2 165,200,995 (GRCm39) missense probably damaging 0.97
R1395:Zfp663 UTSW 2 165,194,492 (GRCm39) missense probably damaging 1.00
R1402:Zfp663 UTSW 2 165,195,890 (GRCm39) missense probably benign 0.14
R1402:Zfp663 UTSW 2 165,195,890 (GRCm39) missense probably benign 0.14
R1503:Zfp663 UTSW 2 165,194,573 (GRCm39) missense probably damaging 0.99
R1587:Zfp663 UTSW 2 165,195,437 (GRCm39) missense probably benign
R1854:Zfp663 UTSW 2 165,195,211 (GRCm39) missense probably benign 0.18
R1867:Zfp663 UTSW 2 165,194,651 (GRCm39) missense possibly damaging 0.74
R3031:Zfp663 UTSW 2 165,195,616 (GRCm39) nonsense probably null
R4643:Zfp663 UTSW 2 165,194,925 (GRCm39) missense probably benign 0.24
R4691:Zfp663 UTSW 2 165,201,050 (GRCm39) intron probably benign
R4977:Zfp663 UTSW 2 165,195,731 (GRCm39) missense probably damaging 0.97
R5135:Zfp663 UTSW 2 165,195,590 (GRCm39) missense possibly damaging 0.95
R5151:Zfp663 UTSW 2 165,195,113 (GRCm39) missense probably benign 0.00
R5639:Zfp663 UTSW 2 165,194,929 (GRCm39) missense probably benign 0.03
R5763:Zfp663 UTSW 2 165,200,355 (GRCm39) nonsense probably null
R6776:Zfp663 UTSW 2 165,200,935 (GRCm39) missense probably damaging 1.00
R6929:Zfp663 UTSW 2 165,195,178 (GRCm39) missense probably benign
R6998:Zfp663 UTSW 2 165,195,922 (GRCm39) missense possibly damaging 0.74
R7035:Zfp663 UTSW 2 165,195,023 (GRCm39) missense probably benign 0.36
R7169:Zfp663 UTSW 2 165,194,359 (GRCm39) missense probably benign 0.00
R7529:Zfp663 UTSW 2 165,194,728 (GRCm39) missense probably damaging 1.00
R7790:Zfp663 UTSW 2 165,194,453 (GRCm39) missense probably damaging 1.00
R8087:Zfp663 UTSW 2 165,195,679 (GRCm39) missense probably benign 0.20
R8715:Zfp663 UTSW 2 165,194,644 (GRCm39) missense probably damaging 1.00
R8934:Zfp663 UTSW 2 165,194,714 (GRCm39) missense probably damaging 1.00
R8966:Zfp663 UTSW 2 165,194,958 (GRCm39) missense probably damaging 1.00
R9257:Zfp663 UTSW 2 165,195,974 (GRCm39) missense probably benign 0.00
R9278:Zfp663 UTSW 2 165,202,010 (GRCm39) critical splice acceptor site probably null
R9524:Zfp663 UTSW 2 165,195,607 (GRCm39) missense probably damaging 0.99
RF004:Zfp663 UTSW 2 165,200,363 (GRCm39) missense probably benign 0.00
Z1177:Zfp663 UTSW 2 165,195,033 (GRCm39) missense probably damaging 0.99
Posted On 2014-05-07