Incidental Mutation 'IGL02007:Zfp663'
ID |
182247 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Zfp663
|
Ensembl Gene |
ENSMUSG00000056824 |
Gene Name |
zinc finger protein 663 |
Synonyms |
LOC381405, Gm1008 |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.068)
|
Stock # |
IGL02007
|
Quality Score |
|
Status
|
|
Chromosome |
2 |
Chromosomal Location |
165193217-165210649 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 165200993 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Alanine
at position 14
(S14A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000099374
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073062]
[ENSMUST00000103085]
[ENSMUST00000141140]
|
AlphaFold |
Q6NXM6 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000073062
AA Change: S14A
PolyPhen 2
Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
|
SMART Domains |
Protein: ENSMUSP00000072813 Gene: ENSMUSG00000056824 AA Change: S14A
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
1.97e-31 |
SMART |
ZnF_C2H2
|
205 |
227 |
3.47e1 |
SMART |
ZnF_C2H2
|
472 |
494 |
2.4e-3 |
SMART |
ZnF_C2H2
|
500 |
522 |
2.99e-4 |
SMART |
ZnF_C2H2
|
528 |
550 |
2.43e-4 |
SMART |
ZnF_C2H2
|
556 |
578 |
4.79e-3 |
SMART |
ZnF_C2H2
|
584 |
606 |
3.95e-4 |
SMART |
ZnF_C2H2
|
612 |
635 |
8.6e-5 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000103085
AA Change: S14A
PolyPhen 2
Score 0.121 (Sensitivity: 0.93; Specificity: 0.86)
|
SMART Domains |
Protein: ENSMUSP00000099374 Gene: ENSMUSG00000056824 AA Change: S14A
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
1.97e-31 |
SMART |
ZnF_C2H2
|
205 |
227 |
3.47e1 |
SMART |
ZnF_C2H2
|
472 |
494 |
2.4e-3 |
SMART |
ZnF_C2H2
|
500 |
522 |
2.99e-4 |
SMART |
ZnF_C2H2
|
528 |
550 |
2.43e-4 |
SMART |
ZnF_C2H2
|
556 |
578 |
4.79e-3 |
SMART |
ZnF_C2H2
|
584 |
606 |
3.95e-4 |
SMART |
ZnF_C2H2
|
612 |
635 |
8.6e-5 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136482
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000141140
AA Change: S14A
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
SMART Domains |
Protein: ENSMUSP00000115254 Gene: ENSMUSG00000056824 AA Change: S14A
Domain | Start | End | E-Value | Type |
KRAB
|
8 |
68 |
1.97e-31 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 28 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam28 |
C |
A |
14: 68,870,668 (GRCm39) |
R335L |
possibly damaging |
Het |
Adgrv1 |
T |
C |
13: 81,716,862 (GRCm39) |
|
probably benign |
Het |
Calcrl |
A |
G |
2: 84,205,668 (GRCm39) |
C8R |
probably benign |
Het |
Cntn4 |
T |
A |
6: 106,632,490 (GRCm39) |
S505T |
probably benign |
Het |
Cyp3a16 |
T |
C |
5: 145,378,758 (GRCm39) |
|
probably benign |
Het |
Dync2i2 |
A |
G |
2: 29,928,402 (GRCm39) |
S75P |
probably benign |
Het |
Fhip1a |
G |
T |
3: 85,629,752 (GRCm39) |
P280T |
probably damaging |
Het |
Gpatch11 |
A |
G |
17: 79,149,593 (GRCm39) |
T198A |
probably benign |
Het |
H2-T15 |
G |
T |
17: 36,367,222 (GRCm39) |
N333K |
possibly damaging |
Het |
Heatr5a |
C |
A |
12: 51,962,941 (GRCm39) |
L986F |
probably damaging |
Het |
Ift172 |
A |
G |
5: 31,443,948 (GRCm39) |
I90T |
probably benign |
Het |
Igkv3-9 |
A |
G |
6: 70,565,445 (GRCm39) |
|
probably benign |
Het |
Iqsec1 |
G |
A |
6: 90,667,331 (GRCm39) |
P369S |
probably benign |
Het |
Myh1 |
C |
A |
11: 67,111,382 (GRCm39) |
T1607K |
probably benign |
Het |
Myo18b |
T |
C |
5: 113,022,838 (GRCm39) |
|
probably benign |
Het |
Nobox |
A |
G |
6: 43,284,472 (GRCm39) |
L58P |
probably damaging |
Het |
Nwd2 |
T |
A |
5: 63,962,042 (GRCm39) |
I542N |
possibly damaging |
Het |
Or4k51 |
A |
G |
2: 111,584,824 (GRCm39) |
T77A |
probably damaging |
Het |
Or5p54 |
A |
G |
7: 107,553,953 (GRCm39) |
Y35C |
probably damaging |
Het |
Osm |
C |
T |
11: 4,189,470 (GRCm39) |
R85W |
probably damaging |
Het |
Pcdh20 |
T |
C |
14: 88,707,031 (GRCm39) |
R90G |
probably benign |
Het |
Pkhd1l1 |
T |
C |
15: 44,397,129 (GRCm39) |
|
probably benign |
Het |
Sec14l2 |
A |
G |
11: 4,061,114 (GRCm39) |
S116P |
probably benign |
Het |
Selenbp2 |
A |
C |
3: 94,605,461 (GRCm39) |
N96H |
possibly damaging |
Het |
Smarcal1 |
T |
C |
1: 72,635,099 (GRCm39) |
S393P |
probably damaging |
Het |
Tbc1d1 |
A |
G |
5: 64,414,335 (GRCm39) |
Q103R |
probably damaging |
Het |
Tmem63c |
T |
C |
12: 87,119,647 (GRCm39) |
Y314H |
probably damaging |
Het |
Zmynd10 |
A |
G |
9: 107,427,731 (GRCm39) |
N345S |
probably damaging |
Het |
|
Other mutations in Zfp663 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00720:Zfp663
|
APN |
2 |
165,194,525 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01382:Zfp663
|
APN |
2 |
165,200,935 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02164:Zfp663
|
APN |
2 |
165,200,968 (GRCm39) |
nonsense |
probably null |
|
IGL02506:Zfp663
|
APN |
2 |
165,195,871 (GRCm39) |
missense |
probably benign |
0.35 |
IGL03173:Zfp663
|
APN |
2 |
165,194,419 (GRCm39) |
missense |
probably damaging |
0.99 |
R0735:Zfp663
|
UTSW |
2 |
165,200,995 (GRCm39) |
missense |
probably damaging |
0.97 |
R1395:Zfp663
|
UTSW |
2 |
165,194,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R1402:Zfp663
|
UTSW |
2 |
165,195,890 (GRCm39) |
missense |
probably benign |
0.14 |
R1402:Zfp663
|
UTSW |
2 |
165,195,890 (GRCm39) |
missense |
probably benign |
0.14 |
R1503:Zfp663
|
UTSW |
2 |
165,194,573 (GRCm39) |
missense |
probably damaging |
0.99 |
R1587:Zfp663
|
UTSW |
2 |
165,195,437 (GRCm39) |
missense |
probably benign |
|
R1854:Zfp663
|
UTSW |
2 |
165,195,211 (GRCm39) |
missense |
probably benign |
0.18 |
R1867:Zfp663
|
UTSW |
2 |
165,194,651 (GRCm39) |
missense |
possibly damaging |
0.74 |
R3031:Zfp663
|
UTSW |
2 |
165,195,616 (GRCm39) |
nonsense |
probably null |
|
R4643:Zfp663
|
UTSW |
2 |
165,194,925 (GRCm39) |
missense |
probably benign |
0.24 |
R4691:Zfp663
|
UTSW |
2 |
165,201,050 (GRCm39) |
intron |
probably benign |
|
R4977:Zfp663
|
UTSW |
2 |
165,195,731 (GRCm39) |
missense |
probably damaging |
0.97 |
R5135:Zfp663
|
UTSW |
2 |
165,195,590 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5151:Zfp663
|
UTSW |
2 |
165,195,113 (GRCm39) |
missense |
probably benign |
0.00 |
R5639:Zfp663
|
UTSW |
2 |
165,194,929 (GRCm39) |
missense |
probably benign |
0.03 |
R5763:Zfp663
|
UTSW |
2 |
165,200,355 (GRCm39) |
nonsense |
probably null |
|
R6776:Zfp663
|
UTSW |
2 |
165,200,935 (GRCm39) |
missense |
probably damaging |
1.00 |
R6929:Zfp663
|
UTSW |
2 |
165,195,178 (GRCm39) |
missense |
probably benign |
|
R6998:Zfp663
|
UTSW |
2 |
165,195,922 (GRCm39) |
missense |
possibly damaging |
0.74 |
R7035:Zfp663
|
UTSW |
2 |
165,195,023 (GRCm39) |
missense |
probably benign |
0.36 |
R7169:Zfp663
|
UTSW |
2 |
165,194,359 (GRCm39) |
missense |
probably benign |
0.00 |
R7529:Zfp663
|
UTSW |
2 |
165,194,728 (GRCm39) |
missense |
probably damaging |
1.00 |
R7790:Zfp663
|
UTSW |
2 |
165,194,453 (GRCm39) |
missense |
probably damaging |
1.00 |
R8087:Zfp663
|
UTSW |
2 |
165,195,679 (GRCm39) |
missense |
probably benign |
0.20 |
R8715:Zfp663
|
UTSW |
2 |
165,194,644 (GRCm39) |
missense |
probably damaging |
1.00 |
R8934:Zfp663
|
UTSW |
2 |
165,194,714 (GRCm39) |
missense |
probably damaging |
1.00 |
R8966:Zfp663
|
UTSW |
2 |
165,194,958 (GRCm39) |
missense |
probably damaging |
1.00 |
R9257:Zfp663
|
UTSW |
2 |
165,195,974 (GRCm39) |
missense |
probably benign |
0.00 |
R9278:Zfp663
|
UTSW |
2 |
165,202,010 (GRCm39) |
critical splice acceptor site |
probably null |
|
R9524:Zfp663
|
UTSW |
2 |
165,195,607 (GRCm39) |
missense |
probably damaging |
0.99 |
RF004:Zfp663
|
UTSW |
2 |
165,200,363 (GRCm39) |
missense |
probably benign |
0.00 |
Z1177:Zfp663
|
UTSW |
2 |
165,195,033 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Posted On |
2014-05-07 |