Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02009:Vmn2r17'

182262

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r17

Ensembl Gene

ENSMUSG00000091879

Gene Name

vomeronasal 2, receptor 17

Synonyms

EG384221

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.092) question?

Stock #

IGL02009

Quality Score

Status

Chromosome

Chromosomal Location

109567879-109601253 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109600714 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 671 (I671L)

Ref Sequence

ENSEMBL: ENSMUSP00000131450 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171841]

AlphaFold

E9PYF5

Predicted Effect

possibly damaging
Transcript: ENSMUST00000171841
AA Change: I671L

PolyPhen 2 Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000131450
Gene: ENSMUSG00000091879
AA Change: I671L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:ANF_receptor	76	465	7e-26	PFAM
Pfam:NCD3G	508	562	3.5e-18	PFAM
Pfam:7tm_3	593	830	4.8e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh1a3	T	C	7: 66,051,789 (GRCm39)	D388G	probably benign	Het
Ankhd1	C	A	18: 36,757,714 (GRCm39)	Q803K	probably damaging	Het
Arrdc3	A	G	13: 81,041,499 (GRCm39)	N180S	probably benign	Het
Atp11b	G	A	3: 35,868,301 (GRCm39)	E458K	probably benign	Het
Bend6	G	A	1: 33,901,827 (GRCm39)	A185V	probably benign	Het
Ccdc121	C	T	5: 31,644,835 (GRCm39)	T196I	probably benign	Het
Chd5	A	G	4: 152,450,670 (GRCm39)	D632G	probably damaging	Het
Clec4a1	A	T	6: 122,909,175 (GRCm39)	H181L	probably benign	Het
Cntnap5a	T	A	1: 116,085,224 (GRCm39)	D387E	probably benign	Het
Colq	G	A	14: 31,257,599 (GRCm39)	S256F	possibly damaging	Het
Cracd	A	G	5: 76,996,817 (GRCm39)	T92A	possibly damaging	Het
Ctdp1	A	G	18: 80,499,187 (GRCm39)	Y252H	probably damaging	Het
Cyp4f17	T	A	17: 32,743,854 (GRCm39)	L344Q	probably damaging	Het
Fam83b	A	G	9: 76,399,604 (GRCm39)	Y500H	probably damaging	Het
Gapvd1	G	A	2: 34,594,203 (GRCm39)	P949L	probably damaging	Het
Gp5	A	G	16: 30,128,482 (GRCm39)	I64T	probably benign	Het
Il31ra	A	G	13: 112,670,401 (GRCm39)	V248A	probably damaging	Het
Kdm4a	C	T	4: 118,017,366 (GRCm39)	A567T	probably benign	Het
Kpna7	T	C	5: 144,930,888 (GRCm39)		probably null	Het
Lrrc8c	G	A	5: 105,755,257 (GRCm39)	R344H	probably damaging	Het
Man1a	G	A	10: 53,801,621 (GRCm39)	L413F	probably damaging	Het
Man1a2	A	T	3: 100,591,978 (GRCm39)	D67E	probably damaging	Het
Mkln1	G	A	6: 31,426,455 (GRCm39)	S243N	probably benign	Het
Mmp19	T	A	10: 128,634,356 (GRCm39)	M299K	probably benign	Het
Msantd2	T	C	9: 37,434,686 (GRCm39)	F309L	possibly damaging	Het
Mstn	A	G	1: 53,101,309 (GRCm39)		probably benign	Het
Nat8f5	A	C	6: 85,794,408 (GRCm39)	I184R	probably benign	Het
Or5d43	C	T	2: 88,105,056 (GRCm39)	M112I	probably benign	Het
Or9m1b	G	T	2: 87,837,117 (GRCm39)	Q2K	probably benign	Het
Pigc	A	G	1: 161,798,134 (GRCm39)	K39E	possibly damaging	Het
Pms2	T	A	5: 143,862,582 (GRCm39)	L563Q	probably benign	Het
Rpap1	A	G	2: 119,610,594 (GRCm39)	S162P	possibly damaging	Het
Rpl3l	A	G	17: 24,951,407 (GRCm39)	K103E	probably damaging	Het
Slc45a1	A	T	4: 150,722,447 (GRCm39)	V479E	probably damaging	Het
Themis2	A	T	4: 132,512,753 (GRCm39)	L491Q	probably damaging	Het
Vmn2r6	C	A	3: 64,445,323 (GRCm39)	V712L	possibly damaging	Het
Zzz3	A	G	3: 152,133,752 (GRCm39)	D270G	possibly damaging	Het

Other mutations in Vmn2r17

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00325:Vmn2r17	APN	5	109,575,858 (GRCm39)	missense	probably benign	0.15
IGL01457:Vmn2r17	APN	5	109,600,898 (GRCm39)	missense	probably benign	0.00
IGL01527:Vmn2r17	APN	5	109,601,006 (GRCm39)	missense	probably damaging	1.00
IGL01693:Vmn2r17	APN	5	109,600,384 (GRCm39)	missense	probably damaging	1.00
IGL01738:Vmn2r17	APN	5	109,577,364 (GRCm39)	missense	probably damaging	1.00
IGL01767:Vmn2r17	APN	5	109,567,903 (GRCm39)	missense	probably benign	0.01
IGL01932:Vmn2r17	APN	5	109,574,916 (GRCm39)	missense	probably benign	0.00
IGL01970:Vmn2r17	APN	5	109,575,813 (GRCm39)	missense	probably damaging	0.97
IGL02365:Vmn2r17	APN	5	109,601,175 (GRCm39)	missense	probably damaging	1.00
IGL02385:Vmn2r17	APN	5	109,582,247 (GRCm39)	missense	probably damaging	1.00
IGL02457:Vmn2r17	APN	5	109,601,012 (GRCm39)	missense	probably damaging	1.00
IGL02646:Vmn2r17	APN	5	109,600,946 (GRCm39)	missense	probably damaging	1.00
IGL02741:Vmn2r17	APN	5	109,568,077 (GRCm39)	missense	probably benign
IGL03213:Vmn2r17	APN	5	109,582,256 (GRCm39)	critical splice donor site	probably null
IGL03216:Vmn2r17	APN	5	109,600,756 (GRCm39)	missense	probably damaging	1.00
IGL03342:Vmn2r17	APN	5	109,575,782 (GRCm39)	missense	probably damaging	1.00
IGL03408:Vmn2r17	APN	5	109,577,238 (GRCm39)	splice site	probably benign
R0349:Vmn2r17	UTSW	5	109,576,202 (GRCm39)	missense	probably damaging	1.00
R0418:Vmn2r17	UTSW	5	109,600,747 (GRCm39)	missense	probably damaging	1.00
R0800:Vmn2r17	UTSW	5	109,575,192 (GRCm39)	splice site	probably benign
R0836:Vmn2r17	UTSW	5	109,575,822 (GRCm39)	missense	possibly damaging	0.89
R1715:Vmn2r17	UTSW	5	109,576,110 (GRCm39)	missense	probably benign	0.00
R1738:Vmn2r17	UTSW	5	109,576,377 (GRCm39)	missense	probably benign	0.10
R1801:Vmn2r17	UTSW	5	109,576,344 (GRCm39)	missense	probably damaging	1.00
R2054:Vmn2r17	UTSW	5	109,600,352 (GRCm39)	missense	probably damaging	0.98
R2060:Vmn2r17	UTSW	5	109,575,075 (GRCm39)	missense	probably benign	0.00
R2192:Vmn2r17	UTSW	5	109,582,144 (GRCm39)	missense	possibly damaging	0.81
R2315:Vmn2r17	UTSW	5	109,575,897 (GRCm39)	missense	probably damaging	1.00
R2374:Vmn2r17	UTSW	5	109,575,104 (GRCm39)	missense	probably benign
R3612:Vmn2r17	UTSW	5	109,577,463 (GRCm39)	missense	probably benign	0.00
R3832:Vmn2r17	UTSW	5	109,576,262 (GRCm39)	missense	probably damaging	1.00
R4273:Vmn2r17	UTSW	5	109,600,832 (GRCm39)	missense	probably benign	0.44
R4494:Vmn2r17	UTSW	5	109,576,335 (GRCm39)	missense	probably damaging	1.00
R4597:Vmn2r17	UTSW	5	109,577,428 (GRCm39)	missense	probably benign	0.01
R4675:Vmn2r17	UTSW	5	109,575,049 (GRCm39)	missense	probably benign	0.00
R4701:Vmn2r17	UTSW	5	109,575,849 (GRCm39)	missense	probably damaging	0.99
R4754:Vmn2r17	UTSW	5	109,600,715 (GRCm39)	missense	probably damaging	0.99
R4841:Vmn2r17	UTSW	5	109,582,246 (GRCm39)	missense	probably damaging	1.00
R4842:Vmn2r17	UTSW	5	109,582,246 (GRCm39)	missense	probably damaging	1.00
R4865:Vmn2r17	UTSW	5	109,574,985 (GRCm39)	missense	probably damaging	1.00
R4902:Vmn2r17	UTSW	5	109,601,220 (GRCm39)	missense	probably benign	0.14
R4989:Vmn2r17	UTSW	5	109,575,739 (GRCm39)	missense	probably benign	0.07
R5101:Vmn2r17	UTSW	5	109,576,217 (GRCm39)	missense	probably damaging	0.99
R5109:Vmn2r17	UTSW	5	109,577,342 (GRCm39)	missense	probably benign	0.06
R5123:Vmn2r17	UTSW	5	109,575,774 (GRCm39)	missense	possibly damaging	0.90
R5474:Vmn2r17	UTSW	5	109,582,150 (GRCm39)	missense	probably damaging	1.00
R5485:Vmn2r17	UTSW	5	109,567,972 (GRCm39)	missense	probably benign	0.06
R5611:Vmn2r17	UTSW	5	109,576,030 (GRCm39)	missense	probably damaging	0.97
R5652:Vmn2r17	UTSW	5	109,577,430 (GRCm39)	missense	probably benign	0.10
R5717:Vmn2r17	UTSW	5	109,575,140 (GRCm39)	missense	possibly damaging	0.94
R5735:Vmn2r17	UTSW	5	109,600,716 (GRCm39)	missense	possibly damaging	0.67
R5766:Vmn2r17	UTSW	5	109,575,139 (GRCm39)	missense	possibly damaging	0.46
R6645:Vmn2r17	UTSW	5	109,576,247 (GRCm39)	missense	probably damaging	1.00
R6786:Vmn2r17	UTSW	5	109,575,695 (GRCm39)	missense	probably benign	0.30
R6821:Vmn2r17	UTSW	5	109,577,331 (GRCm39)	missense	probably damaging	1.00
R6979:Vmn2r17	UTSW	5	109,576,265 (GRCm39)	missense	possibly damaging	0.46
R6984:Vmn2r17	UTSW	5	109,600,533 (GRCm39)	missense	probably benign	0.10
R7269:Vmn2r17	UTSW	5	109,576,337 (GRCm39)	missense	possibly damaging	0.88
R7509:Vmn2r17	UTSW	5	109,575,695 (GRCm39)	missense	probably benign	0.30
R7736:Vmn2r17	UTSW	5	109,600,757 (GRCm39)	missense	probably benign	0.05
R7789:Vmn2r17	UTSW	5	109,600,831 (GRCm39)	missense	possibly damaging	0.77
R7814:Vmn2r17	UTSW	5	109,575,739 (GRCm39)	missense	probably benign	0.07
R7847:Vmn2r17	UTSW	5	109,568,063 (GRCm39)	missense	probably damaging	1.00
R7863:Vmn2r17	UTSW	5	109,568,035 (GRCm39)	missense	probably benign
R7893:Vmn2r17	UTSW	5	109,575,944 (GRCm39)	missense	probably benign	0.05
R8234:Vmn2r17	UTSW	5	109,601,235 (GRCm39)	missense	probably benign	0.01
R8382:Vmn2r17	UTSW	5	109,576,387 (GRCm39)	missense	probably benign	0.01
R8435:Vmn2r17	UTSW	5	109,576,172 (GRCm39)	missense	probably benign	0.01
R8465:Vmn2r17	UTSW	5	109,600,691 (GRCm39)	missense	probably damaging	0.99
R8555:Vmn2r17	UTSW	5	109,600,810 (GRCm39)	missense	probably damaging	0.99
R8900:Vmn2r17	UTSW	5	109,575,863 (GRCm39)	missense	probably benign	0.25
R9293:Vmn2r17	UTSW	5	109,600,712 (GRCm39)	missense	probably damaging	1.00
R9308:Vmn2r17	UTSW	5	109,600,505 (GRCm39)	missense	probably damaging	0.98
R9378:Vmn2r17	UTSW	5	109,575,732 (GRCm39)	missense	possibly damaging	0.94
R9597:Vmn2r17	UTSW	5	109,575,669 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07