Incidental Mutation 'IGL02009:Zzz3'
ID 182289
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zzz3
Ensembl Gene ENSMUSG00000039068
Gene Name zinc finger, ZZ domain containing 3
Synonyms 6430567E01Rik, 3110065C23Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL02009
Quality Score
Status
Chromosome 3
Chromosomal Location 152101110-152168463 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 152133752 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 270 (D270G)
Ref Sequence ENSEMBL: ENSMUSP00000101707 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089982] [ENSMUST00000106100] [ENSMUST00000106101] [ENSMUST00000106103] [ENSMUST00000200570]
AlphaFold Q6KAQ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000089982
AA Change: D270G

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000087428
Gene: ENSMUSG00000039068
AA Change: D270G

DomainStartEndE-ValueType
SANT 657 711 1.42e-9 SMART
low complexity region 776 787 N/A INTRINSIC
low complexity region 799 814 N/A INTRINSIC
ZnF_ZZ 823 871 6.46e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106100
AA Change: D270G

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000101706
Gene: ENSMUSG00000039068
AA Change: D270G

DomainStartEndE-ValueType
SANT 658 712 1.42e-9 SMART
low complexity region 777 788 N/A INTRINSIC
low complexity region 800 815 N/A INTRINSIC
ZnF_ZZ 824 872 6.46e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000106101
AA Change: D270G

PolyPhen 2 Score 0.798 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000101707
Gene: ENSMUSG00000039068
AA Change: D270G

DomainStartEndE-ValueType
SANT 658 712 1.42e-9 SMART
low complexity region 777 788 N/A INTRINSIC
low complexity region 800 815 N/A INTRINSIC
ZnF_ZZ 824 872 6.46e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106103
SMART Domains Protein: ENSMUSP00000101709
Gene: ENSMUSG00000039068

DomainStartEndE-ValueType
SANT 157 211 1.42e-9 SMART
low complexity region 276 287 N/A INTRINSIC
low complexity region 299 314 N/A INTRINSIC
ZnF_ZZ 323 371 6.46e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138115
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150802
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197987
Predicted Effect probably benign
Transcript: ENSMUST00000200570
SMART Domains Protein: ENSMUSP00000143693
Gene: ENSMUSG00000039068

DomainStartEndE-ValueType
SANT 161 215 1.42e-9 SMART
low complexity region 280 291 N/A INTRINSIC
low complexity region 303 318 N/A INTRINSIC
ZnF_ZZ 327 375 6.46e-3 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1a3 T C 7: 66,051,789 (GRCm39) D388G probably benign Het
Ankhd1 C A 18: 36,757,714 (GRCm39) Q803K probably damaging Het
Arrdc3 A G 13: 81,041,499 (GRCm39) N180S probably benign Het
Atp11b G A 3: 35,868,301 (GRCm39) E458K probably benign Het
Bend6 G A 1: 33,901,827 (GRCm39) A185V probably benign Het
Ccdc121 C T 5: 31,644,835 (GRCm39) T196I probably benign Het
Chd5 A G 4: 152,450,670 (GRCm39) D632G probably damaging Het
Clec4a1 A T 6: 122,909,175 (GRCm39) H181L probably benign Het
Cntnap5a T A 1: 116,085,224 (GRCm39) D387E probably benign Het
Colq G A 14: 31,257,599 (GRCm39) S256F possibly damaging Het
Cracd A G 5: 76,996,817 (GRCm39) T92A possibly damaging Het
Ctdp1 A G 18: 80,499,187 (GRCm39) Y252H probably damaging Het
Cyp4f17 T A 17: 32,743,854 (GRCm39) L344Q probably damaging Het
Fam83b A G 9: 76,399,604 (GRCm39) Y500H probably damaging Het
Gapvd1 G A 2: 34,594,203 (GRCm39) P949L probably damaging Het
Gp5 A G 16: 30,128,482 (GRCm39) I64T probably benign Het
Il31ra A G 13: 112,670,401 (GRCm39) V248A probably damaging Het
Kdm4a C T 4: 118,017,366 (GRCm39) A567T probably benign Het
Kpna7 T C 5: 144,930,888 (GRCm39) probably null Het
Lrrc8c G A 5: 105,755,257 (GRCm39) R344H probably damaging Het
Man1a G A 10: 53,801,621 (GRCm39) L413F probably damaging Het
Man1a2 A T 3: 100,591,978 (GRCm39) D67E probably damaging Het
Mkln1 G A 6: 31,426,455 (GRCm39) S243N probably benign Het
Mmp19 T A 10: 128,634,356 (GRCm39) M299K probably benign Het
Msantd2 T C 9: 37,434,686 (GRCm39) F309L possibly damaging Het
Mstn A G 1: 53,101,309 (GRCm39) probably benign Het
Nat8f5 A C 6: 85,794,408 (GRCm39) I184R probably benign Het
Or5d43 C T 2: 88,105,056 (GRCm39) M112I probably benign Het
Or9m1b G T 2: 87,837,117 (GRCm39) Q2K probably benign Het
Pigc A G 1: 161,798,134 (GRCm39) K39E possibly damaging Het
Pms2 T A 5: 143,862,582 (GRCm39) L563Q probably benign Het
Rpap1 A G 2: 119,610,594 (GRCm39) S162P possibly damaging Het
Rpl3l A G 17: 24,951,407 (GRCm39) K103E probably damaging Het
Slc45a1 A T 4: 150,722,447 (GRCm39) V479E probably damaging Het
Themis2 A T 4: 132,512,753 (GRCm39) L491Q probably damaging Het
Vmn2r17 A T 5: 109,600,714 (GRCm39) I671L possibly damaging Het
Vmn2r6 C A 3: 64,445,323 (GRCm39) V712L possibly damaging Het
Other mutations in Zzz3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00691:Zzz3 APN 3 152,134,151 (GRCm39) missense probably benign 0.16
IGL00707:Zzz3 APN 3 152,154,680 (GRCm39) nonsense probably null
IGL00983:Zzz3 APN 3 152,161,447 (GRCm39) splice site probably benign
IGL01586:Zzz3 APN 3 152,161,476 (GRCm39) missense possibly damaging 0.80
IGL01973:Zzz3 APN 3 152,134,007 (GRCm39) missense probably benign 0.00
IGL02002:Zzz3 APN 3 152,157,006 (GRCm39) missense probably damaging 0.98
IGL02260:Zzz3 APN 3 152,157,720 (GRCm39) missense probably benign 0.04
IGL02336:Zzz3 APN 3 152,133,696 (GRCm39) missense possibly damaging 0.74
IGL02454:Zzz3 APN 3 152,134,211 (GRCm39) missense probably benign 0.03
IGL02519:Zzz3 APN 3 152,133,027 (GRCm39) missense probably damaging 1.00
R0067:Zzz3 UTSW 3 152,134,040 (GRCm39) missense possibly damaging 0.88
R0067:Zzz3 UTSW 3 152,134,040 (GRCm39) missense possibly damaging 0.88
R0314:Zzz3 UTSW 3 152,133,085 (GRCm39) missense probably benign 0.00
R0536:Zzz3 UTSW 3 152,154,465 (GRCm39) missense probably damaging 1.00
R1706:Zzz3 UTSW 3 152,154,735 (GRCm39) missense probably damaging 1.00
R2869:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2870:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2871:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R2872:Zzz3 UTSW 3 152,152,481 (GRCm39) synonymous silent
R3927:Zzz3 UTSW 3 152,161,499 (GRCm39) missense probably damaging 1.00
R4195:Zzz3 UTSW 3 152,134,102 (GRCm39) missense probably benign 0.02
R4768:Zzz3 UTSW 3 152,154,420 (GRCm39) missense probably damaging 1.00
R5248:Zzz3 UTSW 3 152,133,182 (GRCm39) missense probably damaging 0.99
R5566:Zzz3 UTSW 3 152,161,461 (GRCm39) missense probably damaging 1.00
R5752:Zzz3 UTSW 3 152,157,759 (GRCm39) missense possibly damaging 0.48
R5782:Zzz3 UTSW 3 152,133,737 (GRCm39) missense possibly damaging 0.69
R5884:Zzz3 UTSW 3 152,156,295 (GRCm39) missense probably damaging 1.00
R6008:Zzz3 UTSW 3 152,133,788 (GRCm39) missense probably benign 0.01
R6155:Zzz3 UTSW 3 152,133,319 (GRCm39) missense possibly damaging 0.57
R6557:Zzz3 UTSW 3 152,134,097 (GRCm39) missense probably damaging 1.00
R6865:Zzz3 UTSW 3 152,133,690 (GRCm39) missense probably benign 0.01
R7344:Zzz3 UTSW 3 152,157,736 (GRCm39) missense probably damaging 0.98
R7588:Zzz3 UTSW 3 152,128,405 (GRCm39) missense possibly damaging 0.85
R7636:Zzz3 UTSW 3 152,133,289 (GRCm39) missense probably benign
R7732:Zzz3 UTSW 3 152,154,479 (GRCm39) missense probably damaging 1.00
R8157:Zzz3 UTSW 3 152,155,285 (GRCm39) missense probably null 0.71
R8490:Zzz3 UTSW 3 152,134,290 (GRCm39) nonsense probably null
R8926:Zzz3 UTSW 3 152,133,529 (GRCm39) missense possibly damaging 0.76
R9143:Zzz3 UTSW 3 152,163,908 (GRCm39) missense probably benign 0.04
R9243:Zzz3 UTSW 3 152,133,920 (GRCm39) missense probably damaging 1.00
R9494:Zzz3 UTSW 3 152,133,468 (GRCm39) missense possibly damaging 0.88
R9540:Zzz3 UTSW 3 152,156,306 (GRCm39) nonsense probably null
X0018:Zzz3 UTSW 3 152,134,370 (GRCm39) missense possibly damaging 0.88
Z1176:Zzz3 UTSW 3 152,154,734 (GRCm39) missense possibly damaging 0.94
Posted On 2014-05-07