Incidental Mutation 'IGL01959:Oosp3'
ID182314
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oosp3
Ensembl Gene ENSMUSG00000055933
Gene Nameoocyte secreted protein 3
SynonymsLOC225923, Gm97
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.307) question?
Stock #IGL01959
Quality Score
Status
Chromosome19
Chromosomal Location11697055-11711874 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 11700922 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Leucine at position 87 (F87L)
Ref Sequence ENSEMBL: ENSMUSP00000064913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069760] [ENSMUST00000119053]
Predicted Effect probably benign
Transcript: ENSMUST00000069760
AA Change: F87L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000064913
Gene: ENSMUSG00000055933
AA Change: F87L

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
PDB:3EF7|B 25 118 1e-5 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000119053
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190477
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9230009I02Rik T C 11: 51,091,818 noncoding transcript Het
Aip A G 19: 4,121,397 I13T probably damaging Het
Cacna2d1 C T 5: 16,212,897 P140S probably benign Het
Cald1 A G 6: 34,753,468 D40G probably damaging Het
Cep250 T A 2: 155,983,359 V1052E possibly damaging Het
Chd1 A G 17: 15,742,173 N731D probably damaging Het
Chml C T 1: 175,687,600 V252I probably benign Het
Cog8 T C 8: 107,056,378 Y93C probably damaging Het
Creld1 G A 6: 113,492,833 A399T probably damaging Het
Cyp2a4 T A 7: 26,307,708 V80E probably damaging Het
Cyp2c37 T A 19: 39,995,833 L255* probably null Het
Cyp2d12 C A 15: 82,555,344 probably benign Het
Dimt1 A G 13: 106,953,455 I229V probably benign Het
Dsc1 G A 18: 20,097,225 T341I probably damaging Het
Ercc3 T A 18: 32,257,358 F567I probably damaging Het
Espl1 C A 15: 102,305,662 probably benign Het
Fcrls T C 3: 87,259,632 D18G probably damaging Het
Fnip1 T A 11: 54,490,912 S296R possibly damaging Het
Fzd5 C A 1: 64,735,946 A219S possibly damaging Het
Gbp7 A G 3: 142,541,347 probably benign Het
Gm3298 T C 14: 5,018,731 L162S probably damaging Het
Hspa1l A G 17: 34,977,135 E50G probably damaging Het
Ipo9 T C 1: 135,420,355 probably null Het
Kazn A G 4: 142,150,884 L185P probably damaging Het
Kcnh8 T C 17: 52,834,607 S293P probably damaging Het
Lrp1b T C 2: 41,312,527 T1191A probably damaging Het
Mnat1 A G 12: 73,181,931 probably benign Het
Msx2 C T 13: 53,468,602 probably benign Het
Ndufs2 T G 1: 171,237,229 I317L probably benign Het
Nms T C 1: 38,941,925 probably benign Het
Pask A G 1: 93,334,607 V177A probably benign Het
Poldip2 G T 11: 78,512,307 probably benign Het
Prr14l A T 5: 32,830,205 S649T possibly damaging Het
Slc6a18 T A 13: 73,677,865 N22I probably damaging Het
Smco2 T A 6: 146,861,710 S228T probably benign Het
Speer4a G A 5: 26,035,904 Q197* probably null Het
Speg A G 1: 75,391,090 K641R probably damaging Het
Strip2 G A 6: 29,928,554 V286M probably damaging Het
Tnfrsf22 C T 7: 143,643,275 probably null Het
Tnpo3 A G 6: 29,589,020 probably benign Het
Top2b T A 14: 16,422,695 N1377K probably benign Het
Trmt1 T A 8: 84,691,376 probably null Het
Trpm1 A G 7: 64,208,975 M266V possibly damaging Het
Vmn1r199 A G 13: 22,383,120 T195A probably benign Het
Vmn2r10 A G 5: 108,997,705 V512A probably benign Het
Zfp777 A G 6: 48,044,341 F116L probably benign Het
Zp3r T A 1: 130,591,451 K253* probably null Het
Other mutations in Oosp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00861:Oosp3 APN 19 11711640 missense probably benign 0.03
IGL02006:Oosp3 APN 19 11699420 missense probably damaging 0.99
IGL02231:Oosp3 APN 19 11699439 missense probably damaging 0.99
IGL02836:Oosp3 APN 19 11700968 missense probably benign 0.03
R1669:Oosp3 UTSW 19 11701014 splice site probably benign
R2045:Oosp3 UTSW 19 11699369 missense probably benign 0.03
R2852:Oosp3 UTSW 19 11699532 critical splice donor site probably null
R4820:Oosp3 UTSW 19 11711633 missense probably damaging 0.97
R5030:Oosp3 UTSW 19 11700944 missense probably benign 0.02
R5524:Oosp3 UTSW 19 11705430 missense possibly damaging 0.66
R5641:Oosp3 UTSW 19 11697173 critical splice donor site probably null
R5933:Oosp3 UTSW 19 11705389 missense probably benign 0.07
R7018:Oosp3 UTSW 19 11699419 missense probably benign 0.00
R7585:Oosp3 UTSW 19 11700958 missense probably benign 0.00
R7958:Oosp3 UTSW 19 11705456 missense probably benign 0.07
Posted On2014-05-07