Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01959:Oosp3'

182314

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oosp3

Ensembl Gene

ENSMUSG00000055933

Gene Name

oocyte secreted protein 3

Synonyms

LOC225923, Gm97

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.411) question?

Stock #

IGL01959

Quality Score

Status

Chromosome

Chromosomal Location

11697055-11711874 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 11700922 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 87 (F87L)

Ref Sequence

ENSEMBL: ENSMUSP00000064913 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069760] [ENSMUST00000119053]

AlphaFold

G5E8D7

Predicted Effect

probably benign
Transcript: ENSMUST00000069760
AA Change: F87L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000064913
Gene: ENSMUSG00000055933
AA Change: F87L

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
PDB:3EF7\|B	25	118	1e-5	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000119053

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190477

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9230009I02Rik	T	C	11: 51,091,818		noncoding transcript	Het
Aip	A	G	19: 4,121,397	I13T	probably damaging	Het
Cacna2d1	C	T	5: 16,212,897	P140S	probably benign	Het
Cald1	A	G	6: 34,753,468	D40G	probably damaging	Het
Cep250	T	A	2: 155,983,359	V1052E	possibly damaging	Het
Chd1	A	G	17: 15,742,173	N731D	probably damaging	Het
Chml	C	T	1: 175,687,600	V252I	probably benign	Het
Cog8	T	C	8: 107,056,378	Y93C	probably damaging	Het
Creld1	G	A	6: 113,492,833	A399T	probably damaging	Het
Cyp2a4	T	A	7: 26,307,708	V80E	probably damaging	Het
Cyp2c37	T	A	19: 39,995,833	L255*	probably null	Het
Cyp2d12	C	A	15: 82,555,344		probably benign	Het
Dimt1	A	G	13: 106,953,455	I229V	probably benign	Het
Dsc1	G	A	18: 20,097,225	T341I	probably damaging	Het
Ercc3	T	A	18: 32,257,358	F567I	probably damaging	Het
Espl1	C	A	15: 102,305,662		probably benign	Het
Fcrls	T	C	3: 87,259,632	D18G	probably damaging	Het
Fnip1	T	A	11: 54,490,912	S296R	possibly damaging	Het
Fzd5	C	A	1: 64,735,946	A219S	possibly damaging	Het
Gbp7	A	G	3: 142,541,347		probably benign	Het
Gm3298	T	C	14: 5,018,731	L162S	probably damaging	Het
Hspa1l	A	G	17: 34,977,135	E50G	probably damaging	Het
Ipo9	T	C	1: 135,420,355		probably null	Het
Kazn	A	G	4: 142,150,884	L185P	probably damaging	Het
Kcnh8	T	C	17: 52,834,607	S293P	probably damaging	Het
Lrp1b	T	C	2: 41,312,527	T1191A	probably damaging	Het
Mnat1	A	G	12: 73,181,931		probably benign	Het
Msx2	C	T	13: 53,468,602		probably benign	Het
Ndufs2	T	G	1: 171,237,229	I317L	probably benign	Het
Nms	T	C	1: 38,941,925		probably benign	Het
Pask	A	G	1: 93,334,607	V177A	probably benign	Het
Poldip2	G	T	11: 78,512,307		probably benign	Het
Prr14l	A	T	5: 32,830,205	S649T	possibly damaging	Het
Slc6a18	T	A	13: 73,677,865	N22I	probably damaging	Het
Smco2	T	A	6: 146,861,710	S228T	probably benign	Het
Speer4a	G	A	5: 26,035,904	Q197*	probably null	Het
Speg	A	G	1: 75,391,090	K641R	probably damaging	Het
Strip2	G	A	6: 29,928,554	V286M	probably damaging	Het
Tnfrsf22	C	T	7: 143,643,275		probably null	Het
Tnpo3	A	G	6: 29,589,020		probably benign	Het
Top2b	T	A	14: 16,422,695	N1377K	probably benign	Het
Trmt1	T	A	8: 84,691,376		probably null	Het
Trpm1	A	G	7: 64,208,975	M266V	possibly damaging	Het
Vmn1r199	A	G	13: 22,383,120	T195A	probably benign	Het
Vmn2r10	A	G	5: 108,997,705	V512A	probably benign	Het
Zfp777	A	G	6: 48,044,341	F116L	probably benign	Het
Zp3r	T	A	1: 130,591,451	K253*	probably null	Het

Other mutations in Oosp3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00861:Oosp3	APN	19	11711640	missense	probably benign	0.03
IGL02006:Oosp3	APN	19	11699420	missense	probably damaging	0.99
IGL02231:Oosp3	APN	19	11699439	missense	probably damaging	0.99
IGL02836:Oosp3	APN	19	11700968	missense	probably benign	0.03
R1669:Oosp3	UTSW	19	11701014	splice site	probably benign
R2045:Oosp3	UTSW	19	11699369	missense	probably benign	0.03
R2852:Oosp3	UTSW	19	11699532	critical splice donor site	probably null
R4820:Oosp3	UTSW	19	11711633	missense	probably damaging	0.97
R5030:Oosp3	UTSW	19	11700944	missense	probably benign	0.02
R5524:Oosp3	UTSW	19	11705430	missense	possibly damaging	0.66
R5641:Oosp3	UTSW	19	11697173	critical splice donor site	probably null
R5933:Oosp3	UTSW	19	11705389	missense	probably benign	0.07
R7018:Oosp3	UTSW	19	11699419	missense	probably benign	0.00
R7585:Oosp3	UTSW	19	11700958	missense	probably benign	0.00
R7958:Oosp3	UTSW	19	11705456	missense	probably benign	0.07
R9238:Oosp3	UTSW	19	11699389	missense	probably damaging	0.97
R9684:Oosp3	UTSW	19	11705442	missense	probably benign	0.31

Posted On

2014-05-07