Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01959:Zfp777'

182321

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp777

Ensembl Gene

ENSMUSG00000071477

Gene Name

zinc finger protein 777

Synonyms

Accession Numbers

Essential gene?

Probably essential (E-score: 0.880) question?

Stock #

IGL01959

Quality Score

Status

Chromosome

Chromosomal Location

48024188-48048911 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 48044341 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 116 (F116L)

Ref Sequence

ENSEMBL: ENSMUSP00000117227 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095944] [ENSMUST00000114583] [ENSMUST00000125385] [ENSMUST00000147281]

AlphaFold

B9EKF4

Predicted Effect

probably benign
Transcript: ENSMUST00000095944
AA Change: F116L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000093637
Gene: ENSMUSG00000071477
AA Change: F116L

Domain	Start	End	E-Value	Type
Pfam:DUF3669	177	256	4.3e-12	PFAM
KRAB	284	344	1.6e-29	SMART
low complexity region	422	433	N/A	INTRINSIC
coiled coil region	454	477	N/A	INTRINSIC
low complexity region	489	505	N/A	INTRINSIC
low complexity region	520	532	N/A	INTRINSIC
low complexity region	539	555	N/A	INTRINSIC
ZnF_C2H2	557	579	1.2e-5	SMART
ZnF_C2H2	585	607	3.8e-5	SMART
ZnF_C2H2	646	668	1.1e-6	SMART
ZnF_C2H2	674	696	4.6e-6	SMART
ZnF_C2H2	704	726	3.2e-7	SMART
ZnF_C2H2	732	754	3.3e-6	SMART
ZnF_C2H2	760	782	8.4e-6	SMART
ZnF_C2H2	788	810	4.9e-5	SMART
ZnF_C2H2	816	838	1.1e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000114583
AA Change: F160L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000110230
Gene: ENSMUSG00000071477
AA Change: F160L

Domain	Start	End	E-Value	Type
low complexity region	2	24	N/A	INTRINSIC
Pfam:DUF3669	231	298	4.7e-12	PFAM
KRAB	328	388	3.96e-27	SMART
low complexity region	466	477	N/A	INTRINSIC
coiled coil region	498	521	N/A	INTRINSIC
low complexity region	533	549	N/A	INTRINSIC
low complexity region	564	576	N/A	INTRINSIC
low complexity region	583	599	N/A	INTRINSIC
ZnF_C2H2	601	623	2.95e-3	SMART
ZnF_C2H2	629	651	8.94e-3	SMART
ZnF_C2H2	690	712	2.43e-4	SMART
ZnF_C2H2	718	740	1.12e-3	SMART
ZnF_C2H2	748	770	7.49e-5	SMART
ZnF_C2H2	776	798	7.9e-4	SMART
ZnF_C2H2	804	826	1.95e-3	SMART
ZnF_C2H2	832	854	1.18e-2	SMART
ZnF_C2H2	860	882	2.53e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000125385

Predicted Effect

probably benign
Transcript: ENSMUST00000147281
AA Change: F116L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000148362

SMART Domains

Protein: ENSMUSP00000116303
Gene: ENSMUSG00000071477

Domain	Start	End	E-Value	Type
Pfam:DUF3669	40	107	6.1e-13	PFAM
KRAB	137	197	3.96e-27	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000175187

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203645

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9230009I02Rik	T	C	11: 51,091,818		noncoding transcript	Het
Aip	A	G	19: 4,121,397	I13T	probably damaging	Het
Cacna2d1	C	T	5: 16,212,897	P140S	probably benign	Het
Cald1	A	G	6: 34,753,468	D40G	probably damaging	Het
Cep250	T	A	2: 155,983,359	V1052E	possibly damaging	Het
Chd1	A	G	17: 15,742,173	N731D	probably damaging	Het
Chml	C	T	1: 175,687,600	V252I	probably benign	Het
Cog8	T	C	8: 107,056,378	Y93C	probably damaging	Het
Creld1	G	A	6: 113,492,833	A399T	probably damaging	Het
Cyp2a4	T	A	7: 26,307,708	V80E	probably damaging	Het
Cyp2c37	T	A	19: 39,995,833	L255*	probably null	Het
Cyp2d12	C	A	15: 82,555,344		probably benign	Het
Dimt1	A	G	13: 106,953,455	I229V	probably benign	Het
Dsc1	G	A	18: 20,097,225	T341I	probably damaging	Het
Ercc3	T	A	18: 32,257,358	F567I	probably damaging	Het
Espl1	C	A	15: 102,305,662		probably benign	Het
Fcrls	T	C	3: 87,259,632	D18G	probably damaging	Het
Fnip1	T	A	11: 54,490,912	S296R	possibly damaging	Het
Fzd5	C	A	1: 64,735,946	A219S	possibly damaging	Het
Gbp7	A	G	3: 142,541,347		probably benign	Het
Gm3298	T	C	14: 5,018,731	L162S	probably damaging	Het
Hspa1l	A	G	17: 34,977,135	E50G	probably damaging	Het
Ipo9	T	C	1: 135,420,355		probably null	Het
Kazn	A	G	4: 142,150,884	L185P	probably damaging	Het
Kcnh8	T	C	17: 52,834,607	S293P	probably damaging	Het
Lrp1b	T	C	2: 41,312,527	T1191A	probably damaging	Het
Mnat1	A	G	12: 73,181,931		probably benign	Het
Msx2	C	T	13: 53,468,602		probably benign	Het
Ndufs2	T	G	1: 171,237,229	I317L	probably benign	Het
Nms	T	C	1: 38,941,925		probably benign	Het
Oosp3	T	A	19: 11,700,922	F87L	probably benign	Het
Pask	A	G	1: 93,334,607	V177A	probably benign	Het
Poldip2	G	T	11: 78,512,307		probably benign	Het
Prr14l	A	T	5: 32,830,205	S649T	possibly damaging	Het
Slc6a18	T	A	13: 73,677,865	N22I	probably damaging	Het
Smco2	T	A	6: 146,861,710	S228T	probably benign	Het
Speer4a	G	A	5: 26,035,904	Q197*	probably null	Het
Speg	A	G	1: 75,391,090	K641R	probably damaging	Het
Strip2	G	A	6: 29,928,554	V286M	probably damaging	Het
Tnfrsf22	C	T	7: 143,643,275		probably null	Het
Tnpo3	A	G	6: 29,589,020		probably benign	Het
Top2b	T	A	14: 16,422,695	N1377K	probably benign	Het
Trmt1	T	A	8: 84,691,376		probably null	Het
Trpm1	A	G	7: 64,208,975	M266V	possibly damaging	Het
Vmn1r199	A	G	13: 22,383,120	T195A	probably benign	Het
Vmn2r10	A	G	5: 108,997,705	V512A	probably benign	Het
Zp3r	T	A	1: 130,591,451	K253*	probably null	Het

Other mutations in Zfp777

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01530:Zfp777	APN	6	48043984	missense	probably damaging	1.00
IGL01916:Zfp777	APN	6	48025342	missense	probably damaging	1.00
IGL02167:Zfp777	APN	6	48044526	missense	probably damaging	0.98
IGL03150:Zfp777	APN	6	48044125	missense	probably damaging	1.00
R0238:Zfp777	UTSW	6	48024969	missense	probably damaging	0.99
R0238:Zfp777	UTSW	6	48024969	missense	probably damaging	0.99
R0372:Zfp777	UTSW	6	48044476	missense	possibly damaging	0.62
R0762:Zfp777	UTSW	6	48029360	missense	probably damaging	1.00
R1300:Zfp777	UTSW	6	48025770	missense	probably benign	0.43
R1727:Zfp777	UTSW	6	48043890	missense	probably damaging	0.99
R1906:Zfp777	UTSW	6	48042061	missense	probably damaging	0.99
R2047:Zfp777	UTSW	6	48044346	missense	probably benign
R2097:Zfp777	UTSW	6	48044242	missense	probably benign	0.08
R2211:Zfp777	UTSW	6	48043885	missense	possibly damaging	0.79
R2898:Zfp777	UTSW	6	48025660	missense	probably damaging	0.97
R3123:Zfp777	UTSW	6	48029116	unclassified	probably benign
R3832:Zfp777	UTSW	6	48044215	missense	probably benign	0.00
R4019:Zfp777	UTSW	6	48042112	missense	probably damaging	1.00
R4077:Zfp777	UTSW	6	48025522	missense	probably benign
R4471:Zfp777	UTSW	6	48042107	missense	probably damaging	1.00
R5021:Zfp777	UTSW	6	48042127	missense	probably damaging	0.99
R5030:Zfp777	UTSW	6	48037667	missense	probably damaging	0.99
R5819:Zfp777	UTSW	6	48037588	missense	probably damaging	0.99
R6544:Zfp777	UTSW	6	48044485	missense	probably damaging	0.98
R6736:Zfp777	UTSW	6	48024856	missense	probably damaging	0.99
R6971:Zfp777	UTSW	6	48024691	missense	probably damaging	1.00
R7240:Zfp777	UTSW	6	48044449	missense	probably benign	0.00
R7258:Zfp777	UTSW	6	48025797	missense	probably damaging	0.99
R7586:Zfp777	UTSW	6	48029218	missense	probably benign	0.33
R7833:Zfp777	UTSW	6	48025138	missense	probably damaging	0.99
R7947:Zfp777	UTSW	6	48024711	missense	probably damaging	1.00
R8136:Zfp777	UTSW	6	48044625	missense	probably benign	0.25
R8151:Zfp777	UTSW	6	48029141	nonsense	probably null
R8348:Zfp777	UTSW	6	48029167	missense	probably damaging	0.99
R8448:Zfp777	UTSW	6	48029167	missense	probably damaging	0.99
R8942:Zfp777	UTSW	6	48029191	missense	probably benign	0.25
R8983:Zfp777	UTSW	6	48029224	missense	probably damaging	1.00
R9205:Zfp777	UTSW	6	48025587	missense	probably benign	0.07
R9397:Zfp777	UTSW	6	48044256	missense	probably benign	0.00
R9562:Zfp777	UTSW	6	48044646	missense	possibly damaging	0.84
R9565:Zfp777	UTSW	6	48044646	missense	possibly damaging	0.84
RF008:Zfp777	UTSW	6	48042048	nonsense	probably null
Z1177:Zfp777	UTSW	6	48025234	missense	probably damaging	1.00

Posted On

2014-05-07