Incidental Mutation 'IGL01960:Tecpr1'
ID 182354
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tecpr1
Ensembl Gene ENSMUSG00000066621
Gene Name tectonin beta-propeller repeat containing 1
Synonyms 2210010N04Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL01960
Quality Score
Status
Chromosome 5
Chromosomal Location 144131260-144160433 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 144153737 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 172 (R172Q)
Ref Sequence ENSEMBL: ENSMUSP00000082844 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000085701]
AlphaFold Q80VP0
Predicted Effect probably benign
Transcript: ENSMUST00000085701
AA Change: R172Q

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000082844
Gene: ENSMUSG00000066621
AA Change: R172Q

DomainStartEndE-ValueType
TECPR 23 59 8.98e1 SMART
DysFN 64 125 6.72e-24 SMART
DysFC 137 170 1.89e-9 SMART
TECPR 192 225 1.79e-1 SMART
TECPR 234 270 2.5e-9 SMART
TECPR 279 317 4.99e-9 SMART
TECPR 326 361 2.42e-7 SMART
low complexity region 381 394 N/A INTRINSIC
PH 614 724 1.69e-2 SMART
TECPR 711 750 1.88e-4 SMART
TECPR 766 800 3.27e-4 SMART
DysFN 821 882 2.95e-20 SMART
DysFC 893 926 1.66e-14 SMART
TECPR 940 974 1.69e1 SMART
TECPR 983 1019 1.45e-5 SMART
TECPR 1028 1065 1.51e-8 SMART
TECPR 1074 1109 1.59e-2 SMART
low complexity region 1125 1137 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136018
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137149
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153103
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153751
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156129
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196360
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy [provided by RefSeq, Nov 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired selective autophagy and abnormal response to bacterial infection in MEFs. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb2 G A 4: 129,906,177 (GRCm39) probably benign Het
Adh7 T C 3: 137,932,043 (GRCm39) I219T probably damaging Het
Ankmy1 C A 1: 92,799,385 (GRCm39) probably benign Het
Aoc1 A G 6: 48,885,537 (GRCm39) I681V probably benign Het
Arfgap3 T C 15: 83,197,758 (GRCm39) T333A probably benign Het
Cdc42ep4 A G 11: 113,619,830 (GRCm39) V187A probably benign Het
Cyp4f40 G A 17: 32,878,535 (GRCm39) G26R probably benign Het
Dnah7b T A 1: 46,163,497 (GRCm39) probably benign Het
Dnajb4 T C 3: 151,892,176 (GRCm39) E219G probably damaging Het
Dnmt3b A G 2: 153,518,631 (GRCm39) K578R possibly damaging Het
Dst A T 1: 34,329,570 (GRCm39) D4649V probably damaging Het
Fam20c T C 5: 138,792,075 (GRCm39) S391P probably damaging Het
Fbxw10 A T 11: 62,767,582 (GRCm39) Y801F probably damaging Het
Frem2 T G 3: 53,429,725 (GRCm39) E2775A probably benign Het
Frmd4b A T 6: 97,272,741 (GRCm39) S830T possibly damaging Het
Gatad2a T G 8: 70,362,598 (GRCm39) S581R possibly damaging Het
Gpcpd1 C T 2: 132,381,818 (GRCm39) probably null Het
Igsf10 A G 3: 59,226,158 (GRCm39) L2505P probably benign Het
Igsf9b A G 9: 27,239,902 (GRCm39) D649G possibly damaging Het
Impact T C 18: 13,107,815 (GRCm39) C28R probably benign Het
Ino80d G T 1: 63,097,306 (GRCm39) Q863K probably damaging Het
Iqsec1 A C 6: 90,653,762 (GRCm39) M675R probably damaging Het
Kcng3 C T 17: 83,895,279 (GRCm39) V396I probably damaging Het
Klhl18 A T 9: 110,279,814 (GRCm39) D60E probably benign Het
Krtap7-1 C T 16: 89,305,156 (GRCm39) probably benign Het
Mal2 T A 15: 54,461,941 (GRCm39) Y145* probably null Het
Mcpt8 A T 14: 56,319,864 (GRCm39) probably null Het
Mdn1 A G 4: 32,758,393 (GRCm39) D4810G probably benign Het
Med24 T C 11: 98,598,368 (GRCm39) I766V probably benign Het
Mga G A 2: 119,769,138 (GRCm39) V1477M probably damaging Het
Mybph T A 1: 134,121,663 (GRCm39) V112E probably benign Het
Nmur2 A T 11: 55,931,337 (GRCm39) S125T probably damaging Het
Or2w3 T C 11: 58,556,691 (GRCm39) V102A probably benign Het
Or6c212 A G 10: 129,558,756 (GRCm39) I219T probably damaging Het
Or8b44 A T 9: 38,410,003 (GRCm39) I13F probably damaging Het
Otop3 A G 11: 115,231,795 (GRCm39) N220S probably damaging Het
Pacsin1 T G 17: 27,923,809 (GRCm39) probably null Het
Pcsk1 A G 13: 75,241,286 (GRCm39) R89G possibly damaging Het
Pde2a A T 7: 101,153,947 (GRCm39) E509V probably benign Het
Pex1 T C 5: 3,677,588 (GRCm39) probably benign Het
Ppp4r4 T G 12: 103,547,753 (GRCm39) probably benign Het
Pygb T A 2: 150,655,403 (GRCm39) N251K probably benign Het
Rsf1 C T 7: 97,310,782 (GRCm39) T504I probably benign Het
Slc5a11 A T 7: 122,869,163 (GRCm39) T584S probably benign Het
Smad2 G A 18: 76,395,555 (GRCm39) probably benign Het
Srsf6 G A 2: 162,775,674 (GRCm39) R161H probably damaging Het
Tbx3 T A 5: 119,820,708 (GRCm39) S573T probably benign Het
Ttn T A 2: 76,619,244 (GRCm39) probably null Het
Ubr2 T C 17: 47,284,893 (GRCm39) M542V probably benign Het
Unc80 T C 1: 66,647,659 (GRCm39) probably benign Het
Vmn1r222 T A 13: 23,416,315 (GRCm39) K299N probably benign Het
Wwp1 A T 4: 19,662,115 (GRCm39) probably benign Het
Zbtb46 T A 2: 181,065,928 (GRCm39) H74L possibly damaging Het
Zfp106 A T 2: 120,354,524 (GRCm39) L1416I probably damaging Het
Zfp106 A G 2: 120,369,803 (GRCm39) L73S probably benign Het
Zfp667 G A 7: 6,308,336 (GRCm39) G335R probably benign Het
Other mutations in Tecpr1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01399:Tecpr1 APN 5 144,145,411 (GRCm39) critical splice donor site probably null
IGL01774:Tecpr1 APN 5 144,148,358 (GRCm39) missense probably damaging 0.97
IGL01973:Tecpr1 APN 5 144,134,806 (GRCm39) splice site probably benign
IGL02244:Tecpr1 APN 5 144,146,821 (GRCm39) missense probably benign
IGL02247:Tecpr1 APN 5 144,143,372 (GRCm39) missense possibly damaging 0.64
IGL02423:Tecpr1 APN 5 144,140,305 (GRCm39) missense possibly damaging 0.88
IGL02679:Tecpr1 APN 5 144,143,364 (GRCm39) missense probably benign 0.28
larghissimo UTSW 5 144,154,075 (GRCm39) missense probably damaging 1.00
PIT4531001:Tecpr1 UTSW 5 144,150,885 (GRCm39) missense probably damaging 0.96
R0121:Tecpr1 UTSW 5 144,147,017 (GRCm39) missense probably benign 0.02
R0125:Tecpr1 UTSW 5 144,134,717 (GRCm39) missense probably damaging 1.00
R0194:Tecpr1 UTSW 5 144,155,335 (GRCm39) missense probably damaging 1.00
R0376:Tecpr1 UTSW 5 144,144,294 (GRCm39) missense possibly damaging 0.94
R0441:Tecpr1 UTSW 5 144,132,759 (GRCm39) missense probably benign
R0504:Tecpr1 UTSW 5 144,150,899 (GRCm39) missense probably damaging 0.99
R0538:Tecpr1 UTSW 5 144,143,092 (GRCm39) missense probably damaging 0.99
R0586:Tecpr1 UTSW 5 144,154,219 (GRCm39) missense probably damaging 1.00
R0607:Tecpr1 UTSW 5 144,149,408 (GRCm39) missense probably damaging 1.00
R0608:Tecpr1 UTSW 5 144,148,317 (GRCm39) missense probably damaging 1.00
R0656:Tecpr1 UTSW 5 144,150,871 (GRCm39) splice site probably null
R0835:Tecpr1 UTSW 5 144,149,410 (GRCm39) missense possibly damaging 0.81
R1080:Tecpr1 UTSW 5 144,153,747 (GRCm39) missense probably damaging 1.00
R1394:Tecpr1 UTSW 5 144,143,357 (GRCm39) missense possibly damaging 0.77
R1597:Tecpr1 UTSW 5 144,151,128 (GRCm39) missense probably benign 0.00
R1663:Tecpr1 UTSW 5 144,134,762 (GRCm39) missense probably benign 0.17
R1785:Tecpr1 UTSW 5 144,145,463 (GRCm39) missense probably benign 0.01
R1786:Tecpr1 UTSW 5 144,145,463 (GRCm39) missense probably benign 0.01
R1833:Tecpr1 UTSW 5 144,145,426 (GRCm39) missense probably damaging 0.99
R1883:Tecpr1 UTSW 5 144,143,347 (GRCm39) missense probably benign 0.03
R1988:Tecpr1 UTSW 5 144,141,515 (GRCm39) missense possibly damaging 0.94
R2130:Tecpr1 UTSW 5 144,145,463 (GRCm39) missense probably benign 0.01
R2131:Tecpr1 UTSW 5 144,145,463 (GRCm39) missense probably benign 0.01
R2132:Tecpr1 UTSW 5 144,145,463 (GRCm39) missense probably benign 0.01
R2133:Tecpr1 UTSW 5 144,145,463 (GRCm39) missense probably benign 0.01
R2172:Tecpr1 UTSW 5 144,148,274 (GRCm39) missense probably benign 0.10
R2172:Tecpr1 UTSW 5 144,133,235 (GRCm39) missense probably damaging 1.00
R2290:Tecpr1 UTSW 5 144,150,881 (GRCm39) missense probably damaging 0.99
R3691:Tecpr1 UTSW 5 144,146,797 (GRCm39) missense probably benign 0.10
R4027:Tecpr1 UTSW 5 144,143,077 (GRCm39) missense probably benign 0.41
R4587:Tecpr1 UTSW 5 144,149,408 (GRCm39) missense probably damaging 0.96
R4684:Tecpr1 UTSW 5 144,144,255 (GRCm39) missense probably benign 0.16
R4864:Tecpr1 UTSW 5 144,150,935 (GRCm39) missense probably benign 0.00
R4932:Tecpr1 UTSW 5 144,141,476 (GRCm39) missense probably damaging 0.97
R4955:Tecpr1 UTSW 5 144,154,075 (GRCm39) missense probably damaging 1.00
R5043:Tecpr1 UTSW 5 144,134,672 (GRCm39) splice site probably null
R5459:Tecpr1 UTSW 5 144,144,234 (GRCm39) missense probably damaging 1.00
R5579:Tecpr1 UTSW 5 144,151,162 (GRCm39) missense possibly damaging 0.55
R5677:Tecpr1 UTSW 5 144,155,451 (GRCm39) nonsense probably null
R5679:Tecpr1 UTSW 5 144,144,241 (GRCm39) missense possibly damaging 0.69
R5802:Tecpr1 UTSW 5 144,143,364 (GRCm39) missense probably benign 0.28
R6000:Tecpr1 UTSW 5 144,148,239 (GRCm39) missense probably benign 0.02
R6022:Tecpr1 UTSW 5 144,136,009 (GRCm39) missense possibly damaging 0.95
R6114:Tecpr1 UTSW 5 144,141,458 (GRCm39) missense possibly damaging 0.81
R6251:Tecpr1 UTSW 5 144,135,394 (GRCm39) missense probably damaging 0.97
R6372:Tecpr1 UTSW 5 144,153,776 (GRCm39) missense probably damaging 1.00
R6493:Tecpr1 UTSW 5 144,146,792 (GRCm39) missense probably benign
R7276:Tecpr1 UTSW 5 144,153,838 (GRCm39) nonsense probably null
R7314:Tecpr1 UTSW 5 144,154,150 (GRCm39) missense probably damaging 1.00
R7375:Tecpr1 UTSW 5 144,145,417 (GRCm39) missense possibly damaging 0.68
R7632:Tecpr1 UTSW 5 144,155,544 (GRCm39) missense probably benign 0.03
R7702:Tecpr1 UTSW 5 144,140,236 (GRCm39) missense probably damaging 1.00
R8135:Tecpr1 UTSW 5 144,135,420 (GRCm39) missense probably damaging 0.99
R8406:Tecpr1 UTSW 5 144,137,658 (GRCm39) missense probably damaging 1.00
R8844:Tecpr1 UTSW 5 144,153,117 (GRCm39) missense possibly damaging 0.94
R8856:Tecpr1 UTSW 5 144,153,117 (GRCm39) missense possibly damaging 0.94
R8857:Tecpr1 UTSW 5 144,153,117 (GRCm39) missense possibly damaging 0.94
R8866:Tecpr1 UTSW 5 144,153,117 (GRCm39) missense possibly damaging 0.94
R8903:Tecpr1 UTSW 5 144,150,845 (GRCm39) intron probably benign
R8926:Tecpr1 UTSW 5 144,153,780 (GRCm39) missense probably damaging 1.00
R9218:Tecpr1 UTSW 5 144,154,049 (GRCm39) missense possibly damaging 0.70
R9423:Tecpr1 UTSW 5 144,155,396 (GRCm39) missense probably damaging 0.98
RF001:Tecpr1 UTSW 5 144,154,204 (GRCm39) missense probably damaging 0.99
Z1176:Tecpr1 UTSW 5 144,155,409 (GRCm39) missense probably benign 0.28
Posted On 2014-05-07