Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01960:Zfp667'

182367

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp667

Ensembl Gene

ENSMUSG00000054893

Gene Name

zinc finger protein 667

Synonyms

A830025F02Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL01960

Quality Score

Status

Chromosome

Chromosomal Location

6289578-6310882 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 6308336 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Arginine at position 335 (G335R)

Ref Sequence

ENSEMBL: ENSMUSP00000128658 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086327] [ENSMUST00000108562] [ENSMUST00000153840] [ENSMUST00000170776]

AlphaFold

Q2TL60

Predicted Effect

probably benign
Transcript: ENSMUST00000086327
AA Change: G335R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000083507
Gene: ENSMUSG00000054893
AA Change: G335R

Domain	Start	End	E-Value	Type
KRAB	14	74	4.77e-30	SMART
ZnF_C2H2	144	166	5.42e-2	SMART
ZnF_C2H2	172	194	3.11e-2	SMART
ZnF_C2H2	200	222	1.67e-2	SMART
ZnF_C2H2	253	275	2.57e-3	SMART
ZnF_C2H2	329	351	2.4e-3	SMART
ZnF_C2H2	357	379	3.16e-3	SMART
ZnF_C2H2	385	407	8.94e-3	SMART
ZnF_C2H2	414	436	5.06e-2	SMART
ZnF_C2H2	442	464	2.4e-3	SMART
ZnF_C2H2	470	492	5.29e-5	SMART
ZnF_C2H2	498	520	7.37e-4	SMART
ZnF_C2H2	526	548	1.38e-3	SMART
ZnF_C2H2	554	576	1.13e-4	SMART
ZnF_C2H2	582	604	1.38e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108562
AA Change: G335R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000104202
Gene: ENSMUSG00000054893
AA Change: G335R

Domain	Start	End	E-Value	Type
KRAB	14	74	4.77e-30	SMART
ZnF_C2H2	144	166	5.42e-2	SMART
ZnF_C2H2	172	194	3.11e-2	SMART
ZnF_C2H2	200	222	1.67e-2	SMART
ZnF_C2H2	253	275	2.57e-3	SMART
ZnF_C2H2	329	351	2.4e-3	SMART
ZnF_C2H2	357	379	3.16e-3	SMART
ZnF_C2H2	385	407	8.94e-3	SMART
ZnF_C2H2	414	436	5.06e-2	SMART
ZnF_C2H2	442	464	2.4e-3	SMART
ZnF_C2H2	470	492	5.29e-5	SMART
ZnF_C2H2	498	520	7.37e-4	SMART
ZnF_C2H2	526	548	1.38e-3	SMART
ZnF_C2H2	554	576	1.13e-4	SMART
ZnF_C2H2	582	604	1.38e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000153840

Predicted Effect

probably benign
Transcript: ENSMUST00000170776
AA Change: G335R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000128658
Gene: ENSMUSG00000054893
AA Change: G335R

Domain	Start	End	E-Value	Type
KRAB	14	74	4.77e-30	SMART
ZnF_C2H2	144	166	5.42e-2	SMART
ZnF_C2H2	172	194	3.11e-2	SMART
ZnF_C2H2	200	222	1.67e-2	SMART
ZnF_C2H2	253	275	2.57e-3	SMART
ZnF_C2H2	329	351	2.4e-3	SMART
ZnF_C2H2	357	379	3.16e-3	SMART
ZnF_C2H2	385	407	8.94e-3	SMART
ZnF_C2H2	414	436	5.06e-2	SMART
ZnF_C2H2	442	464	2.4e-3	SMART
ZnF_C2H2	470	492	5.29e-5	SMART
ZnF_C2H2	498	520	7.37e-4	SMART
ZnF_C2H2	526	548	1.38e-3	SMART
ZnF_C2H2	554	576	1.13e-4	SMART
ZnF_C2H2	582	604	1.38e-3	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

All alleles(4) : Targeted, other(2) Gene trapped(2)

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb2	G	A	4: 129,906,177 (GRCm39)		probably benign	Het
Adh7	T	C	3: 137,932,043 (GRCm39)	I219T	probably damaging	Het
Ankmy1	C	A	1: 92,799,385 (GRCm39)		probably benign	Het
Aoc1	A	G	6: 48,885,537 (GRCm39)	I681V	probably benign	Het
Arfgap3	T	C	15: 83,197,758 (GRCm39)	T333A	probably benign	Het
Cdc42ep4	A	G	11: 113,619,830 (GRCm39)	V187A	probably benign	Het
Cyp4f40	G	A	17: 32,878,535 (GRCm39)	G26R	probably benign	Het
Dnah7b	T	A	1: 46,163,497 (GRCm39)		probably benign	Het
Dnajb4	T	C	3: 151,892,176 (GRCm39)	E219G	probably damaging	Het
Dnmt3b	A	G	2: 153,518,631 (GRCm39)	K578R	possibly damaging	Het
Dst	A	T	1: 34,329,570 (GRCm39)	D4649V	probably damaging	Het
Fam20c	T	C	5: 138,792,075 (GRCm39)	S391P	probably damaging	Het
Fbxw10	A	T	11: 62,767,582 (GRCm39)	Y801F	probably damaging	Het
Frem2	T	G	3: 53,429,725 (GRCm39)	E2775A	probably benign	Het
Frmd4b	A	T	6: 97,272,741 (GRCm39)	S830T	possibly damaging	Het
Gatad2a	T	G	8: 70,362,598 (GRCm39)	S581R	possibly damaging	Het
Gpcpd1	C	T	2: 132,381,818 (GRCm39)		probably null	Het
Igsf10	A	G	3: 59,226,158 (GRCm39)	L2505P	probably benign	Het
Igsf9b	A	G	9: 27,239,902 (GRCm39)	D649G	possibly damaging	Het
Impact	T	C	18: 13,107,815 (GRCm39)	C28R	probably benign	Het
Ino80d	G	T	1: 63,097,306 (GRCm39)	Q863K	probably damaging	Het
Iqsec1	A	C	6: 90,653,762 (GRCm39)	M675R	probably damaging	Het
Kcng3	C	T	17: 83,895,279 (GRCm39)	V396I	probably damaging	Het
Klhl18	A	T	9: 110,279,814 (GRCm39)	D60E	probably benign	Het
Krtap7-1	C	T	16: 89,305,156 (GRCm39)		probably benign	Het
Mal2	T	A	15: 54,461,941 (GRCm39)	Y145*	probably null	Het
Mcpt8	A	T	14: 56,319,864 (GRCm39)		probably null	Het
Mdn1	A	G	4: 32,758,393 (GRCm39)	D4810G	probably benign	Het
Med24	T	C	11: 98,598,368 (GRCm39)	I766V	probably benign	Het
Mga	G	A	2: 119,769,138 (GRCm39)	V1477M	probably damaging	Het
Mybph	T	A	1: 134,121,663 (GRCm39)	V112E	probably benign	Het
Nmur2	A	T	11: 55,931,337 (GRCm39)	S125T	probably damaging	Het
Or2w3	T	C	11: 58,556,691 (GRCm39)	V102A	probably benign	Het
Or6c212	A	G	10: 129,558,756 (GRCm39)	I219T	probably damaging	Het
Or8b44	A	T	9: 38,410,003 (GRCm39)	I13F	probably damaging	Het
Otop3	A	G	11: 115,231,795 (GRCm39)	N220S	probably damaging	Het
Pacsin1	T	G	17: 27,923,809 (GRCm39)		probably null	Het
Pcsk1	A	G	13: 75,241,286 (GRCm39)	R89G	possibly damaging	Het
Pde2a	A	T	7: 101,153,947 (GRCm39)	E509V	probably benign	Het
Pex1	T	C	5: 3,677,588 (GRCm39)		probably benign	Het
Ppp4r4	T	G	12: 103,547,753 (GRCm39)		probably benign	Het
Pygb	T	A	2: 150,655,403 (GRCm39)	N251K	probably benign	Het
Rsf1	C	T	7: 97,310,782 (GRCm39)	T504I	probably benign	Het
Slc5a11	A	T	7: 122,869,163 (GRCm39)	T584S	probably benign	Het
Smad2	G	A	18: 76,395,555 (GRCm39)		probably benign	Het
Srsf6	G	A	2: 162,775,674 (GRCm39)	R161H	probably damaging	Het
Tbx3	T	A	5: 119,820,708 (GRCm39)	S573T	probably benign	Het
Tecpr1	C	T	5: 144,153,737 (GRCm39)	R172Q	probably benign	Het
Ttn	T	A	2: 76,619,244 (GRCm39)		probably null	Het
Ubr2	T	C	17: 47,284,893 (GRCm39)	M542V	probably benign	Het
Unc80	T	C	1: 66,647,659 (GRCm39)		probably benign	Het
Vmn1r222	T	A	13: 23,416,315 (GRCm39)	K299N	probably benign	Het
Wwp1	A	T	4: 19,662,115 (GRCm39)		probably benign	Het
Zbtb46	T	A	2: 181,065,928 (GRCm39)	H74L	possibly damaging	Het
Zfp106	A	T	2: 120,354,524 (GRCm39)	L1416I	probably damaging	Het
Zfp106	A	G	2: 120,369,803 (GRCm39)	L73S	probably benign	Het

Other mutations in Zfp667

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00821:Zfp667	APN	7	6,308,396 (GRCm39)	missense	possibly damaging	0.53
IGL01325:Zfp667	APN	7	6,293,545 (GRCm39)	missense	probably damaging	1.00
IGL01386:Zfp667	APN	7	6,307,869 (GRCm39)	missense	probably benign	0.00
IGL03394:Zfp667	APN	7	6,292,438 (GRCm39)	critical splice donor site	probably null
B5639:Zfp667	UTSW	7	6,293,544 (GRCm39)	missense	probably damaging	1.00
R0458:Zfp667	UTSW	7	6,307,844 (GRCm39)	missense	probably benign	0.40
R0845:Zfp667	UTSW	7	6,309,091 (GRCm39)	missense	possibly damaging	0.85
R1768:Zfp667	UTSW	7	6,308,066 (GRCm39)	missense	possibly damaging	0.53
R1953:Zfp667	UTSW	7	6,308,087 (GRCm39)	missense	probably benign	0.04
R2023:Zfp667	UTSW	7	6,308,416 (GRCm39)	missense	possibly damaging	0.85
R3159:Zfp667	UTSW	7	6,308,999 (GRCm39)	missense	probably damaging	1.00
R4080:Zfp667	UTSW	7	6,308,105 (GRCm39)	missense	possibly damaging	0.71
R4476:Zfp667	UTSW	7	6,307,598 (GRCm39)	missense	possibly damaging	0.53
R4584:Zfp667	UTSW	7	6,293,624 (GRCm39)	missense	possibly damaging	0.84
R4783:Zfp667	UTSW	7	6,308,684 (GRCm39)	missense	possibly damaging	0.83
R5037:Zfp667	UTSW	7	6,308,949 (GRCm39)	missense	possibly damaging	0.71
R5300:Zfp667	UTSW	7	6,307,635 (GRCm39)	missense	probably benign
R5311:Zfp667	UTSW	7	6,308,715 (GRCm39)	missense	probably benign	0.10
R5312:Zfp667	UTSW	7	6,308,466 (GRCm39)	missense	probably benign
R5340:Zfp667	UTSW	7	6,308,252 (GRCm39)	missense	possibly damaging	0.53
R6262:Zfp667	UTSW	7	6,307,973 (GRCm39)	missense	probably benign	0.03
R7386:Zfp667	UTSW	7	6,308,949 (GRCm39)	missense	possibly damaging	0.86
R8383:Zfp667	UTSW	7	6,308,370 (GRCm39)	missense	probably damaging	0.98
R8919:Zfp667	UTSW	7	6,308,256 (GRCm39)	missense	possibly damaging	0.53
R9099:Zfp667	UTSW	7	6,308,322 (GRCm39)	missense	probably benign	0.00
R9422:Zfp667	UTSW	7	6,308,321 (GRCm39)	missense	probably benign	0.00
Z1177:Zfp667	UTSW	7	6,307,856 (GRCm39)	missense	possibly damaging	0.91

Posted On

2014-05-07