Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01970:Leng9'

182522

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Leng9

Ensembl Gene

ENSMUSG00000043432

Gene Name

leukocyte receptor cluster (LRC) member 9

Synonyms

9530024C23Rik, F630035L11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL01970

Quality Score

Status

Chromosome

Chromosomal Location

4151182-4152871 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 4151326 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 450 (Y450C)

Ref Sequence

ENSEMBL: ENSMUSP00000061079 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037472] [ENSMUST00000058358] [ENSMUST00000076831] [ENSMUST00000121270] [ENSMUST00000140410] [ENSMUST00000143825]

AlphaFold

Q8BTN6

Predicted Effect

probably benign
Transcript: ENSMUST00000037472

SMART Domains

Protein: ENSMUSP00000046465
Gene: ENSMUSG00000035545

Domain	Start	End	E-Value	Type
low complexity region	47	69	N/A	INTRINSIC
low complexity region	73	118	N/A	INTRINSIC
low complexity region	156	174	N/A	INTRINSIC
low complexity region	383	396	N/A	INTRINSIC
low complexity region	413	447	N/A	INTRINSIC
low complexity region	453	468	N/A	INTRINSIC
Pfam:SAC3_GANP	567	762	8.2e-66	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000058358
AA Change: Y450C

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000061079
Gene: ENSMUSG00000043432
AA Change: Y450C

Domain	Start	End	E-Value	Type
ZnF_C3H1	8	34	1.72e-4	SMART
Pfam:DUF504	77	128	1.9e-11	PFAM
Pfam:AKAP7_NLS	305	484	2.5e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000076831

SMART Domains

Protein: ENSMUSP00000092508
Gene: ENSMUSG00000063838

Domain	Start	End	E-Value	Type
PBD	23	57	5.86e-6	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000121270

SMART Domains

Protein: ENSMUSP00000112428
Gene: ENSMUSG00000035545

Domain	Start	End	E-Value	Type
low complexity region	47	69	N/A	INTRINSIC
low complexity region	73	118	N/A	INTRINSIC
low complexity region	156	174	N/A	INTRINSIC
low complexity region	383	396	N/A	INTRINSIC
low complexity region	413	447	N/A	INTRINSIC
low complexity region	453	468	N/A	INTRINSIC
Pfam:SAC3_GANP	567	764	7.4e-67	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127723

Predicted Effect

probably benign
Transcript: ENSMUST00000140410

Predicted Effect

probably benign
Transcript: ENSMUST00000143825

SMART Domains

Protein: ENSMUSP00000117257
Gene: ENSMUSG00000063838

Domain	Start	End	E-Value	Type
PBD	23	57	5.86e-6	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000146434

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Cdk9	T	C	2: 32,598,063 (GRCm39)	H280R	possibly damaging	Het
Cenpt	C	T	8: 106,571,748 (GRCm39)	R461H	probably damaging	Het
Cpa4	A	G	6: 30,579,645 (GRCm39)	T151A	probably benign	Het
Glrb	A	G	3: 80,769,232 (GRCm39)	I165T	possibly damaging	Het
Gm17305	A	T	11: 69,255,646 (GRCm39)		probably benign	Het
Kdm5b	T	A	1: 134,528,465 (GRCm39)	S391T	probably damaging	Het
Klrg2	T	C	6: 38,613,383 (GRCm39)	K207E	probably damaging	Het
Krt1	T	C	15: 101,755,299 (GRCm39)	I487V	possibly damaging	Het
Krt27	A	G	11: 99,239,547 (GRCm39)	L311P	probably damaging	Het
Oacyl	A	T	18: 65,882,785 (GRCm39)	I627F	possibly damaging	Het
Perm1	G	T	4: 156,302,118 (GRCm39)	G221W	probably damaging	Het
Rft1	C	T	14: 30,412,492 (GRCm39)	L518F	probably benign	Het
Sdk1	A	T	5: 142,071,437 (GRCm39)	Q1209L	possibly damaging	Het
Selenbp1	A	G	3: 94,844,313 (GRCm39)	S57G	probably benign	Het
Sema5a	T	C	15: 32,686,792 (GRCm39)	M968T	probably benign	Het
Slc16a3	G	A	11: 120,847,864 (GRCm39)	V351M	probably damaging	Het
Sorbs2	G	A	8: 46,198,840 (GRCm39)	V73I	probably damaging	Het
Specc1l	T	A	10: 75,081,595 (GRCm39)	D347E	probably damaging	Het
Tas2r116	A	C	6: 132,832,632 (GRCm39)	T78P	probably benign	Het
Tpm3	A	G	3: 89,997,135 (GRCm39)	E224G	probably damaging	Het
Trnau1ap	T	C	4: 132,041,298 (GRCm39)		probably benign	Het
Vmn2r17	T	A	5: 109,575,813 (GRCm39)	M228K	probably damaging	Het
Vnn1	T	C	10: 23,773,300 (GRCm39)	I109T	probably benign	Het
Wee1	C	A	7: 109,738,457 (GRCm39)	H523Q	probably damaging	Het
Xpr1	T	C	1: 155,165,980 (GRCm39)	N524S	probably benign	Het

Other mutations in Leng9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01903:Leng9	APN	7	4,151,746 (GRCm39)	missense	probably damaging	1.00
IGL02197:Leng9	APN	7	4,151,723 (GRCm39)	missense	probably damaging	1.00
IGL03013:Leng9	APN	7	4,151,737 (GRCm39)	missense	probably damaging	1.00
R1616:Leng9	UTSW	7	4,151,902 (GRCm39)	missense	probably benign	0.00
R2352:Leng9	UTSW	7	4,152,409 (GRCm39)	missense	probably damaging	1.00
R2419:Leng9	UTSW	7	4,151,626 (GRCm39)	missense	probably benign	0.32
R4156:Leng9	UTSW	7	4,152,433 (GRCm39)	missense	possibly damaging	0.70
R4832:Leng9	UTSW	7	4,152,029 (GRCm39)	missense	probably damaging	0.99
R4841:Leng9	UTSW	7	4,152,385 (GRCm39)	missense	probably damaging	1.00
R4842:Leng9	UTSW	7	4,152,385 (GRCm39)	missense	probably damaging	1.00
R7468:Leng9	UTSW	7	4,151,800 (GRCm39)	missense	probably benign
R7627:Leng9	UTSW	7	4,151,617 (GRCm39)	missense	probably damaging	1.00
R7679:Leng9	UTSW	7	4,152,659 (GRCm39)	missense	probably benign	0.11
R8885:Leng9	UTSW	7	4,151,774 (GRCm39)	missense	possibly damaging	0.95
R8951:Leng9	UTSW	7	4,152,782 (GRCm39)	unclassified	probably benign
R9062:Leng9	UTSW	7	4,151,666 (GRCm39)	missense	probably damaging	1.00
R9140:Leng9	UTSW	7	4,152,657 (GRCm39)	missense	probably benign
R9275:Leng9	UTSW	7	4,151,447 (GRCm39)	missense	probably benign	0.02
R9418:Leng9	UTSW	7	4,151,354 (GRCm39)	missense	probably benign	0.01
R9582:Leng9	UTSW	7	4,152,263 (GRCm39)	missense	probably damaging	1.00
X0058:Leng9	UTSW	7	4,152,382 (GRCm39)	missense	possibly damaging	0.56

Posted On

2014-05-07