Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01973:Ighg2b'

182569

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ighg2b

Ensembl Gene

ENSMUSG00000076613

Gene Name

immunoglobulin heavy constant gamma 2B

Synonyms

IgG2b, gamma2b

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

IGL01973

Quality Score

Status

Chromosome

Chromosomal Location

113267934-113271553 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 113271305 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 83 (V83I)

Gene Model

predicted gene model for transcript(s):

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000103418
AA Change: V83I

SMART Domains

Protein: ENSMUSP00000100214
Gene: ENSMUSG00000076613
AA Change: V83I

Domain	Start	End	E-Value	Type
IGc1	22	92	6.9e-16	SMART
low complexity region	108	121	N/A	INTRINSIC
IG_like	145	220	4.02e-2	SMART
IGc1	251	324	1.64e-31	SMART

Predicted Effect

unknown
Transcript: ENSMUST00000192188
AA Change: V83I

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410004P03Rik	A	G	12: 17,061,172 (GRCm39)	W59R	probably damaging	Het
Adam17	C	T	12: 21,399,944 (GRCm39)	R154K	probably damaging	Het
Ajm1	G	T	2: 25,469,584 (GRCm39)	S109*	probably null	Het
Atp9b	A	T	18: 80,801,518 (GRCm39)	F791I	probably benign	Het
Atr	T	G	9: 95,753,727 (GRCm39)	S776R	probably damaging	Het
AW554918	A	T	18: 25,553,056 (GRCm39)	T487S	probably damaging	Het
Bckdhb	T	A	9: 83,873,789 (GRCm39)	F217Y	probably benign	Het
Cacna1i	G	A	15: 80,266,234 (GRCm39)	A1574T	probably damaging	Het
Ccdc150	G	A	1: 54,339,647 (GRCm39)		probably null	Het
Clca4c-ps	A	T	3: 144,585,593 (GRCm39)		noncoding transcript	Het
Clec4a1	T	C	6: 122,907,680 (GRCm39)	S123P	probably damaging	Het
Col6a4	T	C	9: 105,940,093 (GRCm39)	Y1279C	probably damaging	Het
Cox8c	T	A	12: 102,865,626 (GRCm39)	M1K	probably null	Het
Crat	G	T	2: 30,295,493 (GRCm39)	S370Y	probably damaging	Het
Cts7	A	T	13: 61,503,414 (GRCm39)	D183E	probably benign	Het
Cyp1a2	C	A	9: 57,589,678 (GRCm39)	W45C	probably damaging	Het
Eml5	T	A	12: 98,829,539 (GRCm39)	I492L	probably benign	Het
Fbxl4	T	G	4: 22,422,766 (GRCm39)	L456R	probably damaging	Het
Flt1	G	T	5: 147,620,699 (GRCm39)	H148Q	probably benign	Het
Galnt3	T	C	2: 65,914,606 (GRCm39)	M604V	probably benign	Het
Gatb	T	C	3: 85,518,731 (GRCm39)	V279A	probably damaging	Het
Heatr1	C	A	13: 12,444,680 (GRCm39)	H1543Q	probably benign	Het
Jcad	A	G	18: 4,675,514 (GRCm39)	Q1092R	probably benign	Het
Kirrel3	A	G	9: 34,927,764 (GRCm39)	E6G	probably damaging	Het
Klhl22	A	G	16: 17,610,575 (GRCm39)	S609G	probably benign	Het
Kntc1	A	G	5: 123,904,021 (GRCm39)	Y346C	probably damaging	Het
Maneal	T	C	4: 124,752,948 (GRCm39)	D233G	probably benign	Het
Mcm3ap	T	C	10: 76,306,951 (GRCm39)	S355P	probably benign	Het
Mtus2	C	T	5: 148,240,286 (GRCm39)		probably benign	Het
Muc4	A	G	16: 32,575,383 (GRCm39)	T1380A	probably benign	Het
Nedd4	T	A	9: 72,644,216 (GRCm39)	M661K	possibly damaging	Het
Nomo1	T	C	7: 45,732,651 (GRCm39)		probably benign	Het
Ntmt2	A	G	1: 163,544,689 (GRCm39)	I98T	probably benign	Het
Ntsr2	T	A	12: 16,706,775 (GRCm39)	W268R	probably benign	Het
Nup188	A	C	2: 30,229,862 (GRCm39)	Q1360P	possibly damaging	Het
Or2c1	A	T	16: 3,657,641 (GRCm39)	Q268L	probably damaging	Het
Or6k6	A	G	1: 173,945,099 (GRCm39)	F161S	probably damaging	Het
Pabpc1	A	T	15: 36,599,519 (GRCm39)	V392E	probably benign	Het
Pcdhb11	C	A	18: 37,556,565 (GRCm39)	R632S	probably damaging	Het
Phf11	A	G	14: 59,488,578 (GRCm39)	V73A	probably benign	Het
Pnpla6	T	A	8: 3,567,619 (GRCm39)	M87K	probably damaging	Het
Prkd1	C	T	12: 50,413,162 (GRCm39)	G670R	probably damaging	Het
Raf1	G	A	6: 115,653,530 (GRCm39)		probably benign	Het
Rapgef2	T	A	3: 78,999,116 (GRCm39)		probably null	Het
Rnf215	A	T	11: 4,086,615 (GRCm39)	H164L	probably damaging	Het
Slc24a3	T	C	2: 145,086,947 (GRCm39)	V19A	probably benign	Het
Tbc1d16	A	T	11: 119,047,533 (GRCm39)	V396E	probably benign	Het
Tecpr1	T	C	5: 144,134,806 (GRCm39)		probably benign	Het
Thap12	T	A	7: 98,365,706 (GRCm39)	Y625N	possibly damaging	Het
Tshz2	A	T	2: 169,726,603 (GRCm39)	M400L	probably damaging	Het
Ttc28	A	G	5: 111,372,101 (GRCm39)	Y850C	possibly damaging	Het
Ugt1a7c	A	G	1: 88,022,856 (GRCm39)	D5G	probably benign	Het
Vmn2r10	C	T	5: 109,143,543 (GRCm39)	M802I	probably damaging	Het
Washc4	T	C	10: 83,391,973 (GRCm39)	Y220H	probably damaging	Het
Zfhx3	T	A	8: 109,673,825 (GRCm39)	M1625K	probably damaging	Het
Zfp677	T	A	17: 21,617,169 (GRCm39)	N75K	probably damaging	Het
Zzz3	T	C	3: 152,134,007 (GRCm39)	V355A	probably benign	Het

Other mutations in Ighg2b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01366:Ighg2b	APN	12	113,270,656 (GRCm39)	missense	possibly damaging	0.79
IGL01837:Ighg2b	APN	12	113,270,065 (GRCm39)	missense	unknown
IGL01998:Ighg2b	APN	12	113,270,709 (GRCm39)	missense	unknown
IGL02147:Ighg2b	APN	12	113,270,011 (GRCm39)	makesense	probably null
IGL02183:Ighg2b	APN	12	113,271,449 (GRCm39)	missense	unknown
IGL03089:Ighg2b	APN	12	113,270,298 (GRCm39)	missense	probably damaging	1.00
PIT4453001:Ighg2b	UTSW	12	113,270,492 (GRCm39)	missense	unknown
R4199:Ighg2b	UTSW	12	113,270,907 (GRCm39)	missense	probably damaging	0.96
R4459:Ighg2b	UTSW	12	113,270,578 (GRCm39)	missense	unknown
R4577:Ighg2b	UTSW	12	113,270,512 (GRCm39)	missense	unknown
R4589:Ighg2b	UTSW	12	113,270,104 (GRCm39)	missense	unknown
R4807:Ighg2b	UTSW	12	113,267,965 (GRCm39)	unclassified	probably benign
R4822:Ighg2b	UTSW	12	113,270,011 (GRCm39)	makesense	probably null
R5424:Ighg2b	UTSW	12	113,271,550 (GRCm39)	missense	unknown
R5641:Ighg2b	UTSW	12	113,270,767 (GRCm39)	missense	unknown
R6297:Ighg2b	UTSW	12	113,270,512 (GRCm39)	missense	unknown
R6701:Ighg2b	UTSW	12	113,270,699 (GRCm39)	missense	unknown
R6703:Ighg2b	UTSW	12	113,268,653 (GRCm39)	unclassified	probably benign
R6880:Ighg2b	UTSW	12	113,270,726 (GRCm39)	missense
R7342:Ighg2b	UTSW	12	113,270,050 (GRCm39)	missense
R7505:Ighg2b	UTSW	12	113,268,600 (GRCm39)	missense
R7908:Ighg2b	UTSW	12	113,270,074 (GRCm39)	missense
R8543:Ighg2b	UTSW	12	113,270,552 (GRCm39)	missense	probably damaging	1.00
R8951:Ighg2b	UTSW	12	113,270,926 (GRCm39)	missense	probably benign
R9237:Ighg2b	UTSW	12	113,270,217 (GRCm39)	missense
R9539:Ighg2b	UTSW	12	113,270,498 (GRCm39)	missense
R9789:Ighg2b	UTSW	12	113,270,304 (GRCm39)	missense

Posted On

2014-05-07