Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01973:Or6k6'

182599

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or6k6

Ensembl Gene

ENSMUSG00000046486

Gene Name

olfactory receptor family 6 subfamily K member 6

Synonyms

Olfr425, GA_x6K02T02K39-452-3, Olfr244, Olfr231, GA_x6K02T2P20D-21053942-21054499, GA_x6K02T2LER7-6-623, MOR105-4

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.178) question?

Stock #

IGL01973

Quality Score

Status

Chromosome

Chromosomal Location

173944657-173945580 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 173945099 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 161 (F161S)

Ref Sequence

ENSEMBL: ENSMUSP00000151011 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000063030] [ENSMUST00000214446]

AlphaFold

E9Q0M4

Predicted Effect

probably damaging
Transcript: ENSMUST00000063030
AA Change: F161S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000059596
Gene: ENSMUSG00000046486
AA Change: F161S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	24	300	2.6e-63	PFAM
Pfam:7tm_1	34	282	2.7e-21	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000214446
AA Change: F161S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410004P03Rik	A	G	12: 17,061,172 (GRCm39)	W59R	probably damaging	Het
Adam17	C	T	12: 21,399,944 (GRCm39)	R154K	probably damaging	Het
Ajm1	G	T	2: 25,469,584 (GRCm39)	S109*	probably null	Het
Atp9b	A	T	18: 80,801,518 (GRCm39)	F791I	probably benign	Het
Atr	T	G	9: 95,753,727 (GRCm39)	S776R	probably damaging	Het
AW554918	A	T	18: 25,553,056 (GRCm39)	T487S	probably damaging	Het
Bckdhb	T	A	9: 83,873,789 (GRCm39)	F217Y	probably benign	Het
Cacna1i	G	A	15: 80,266,234 (GRCm39)	A1574T	probably damaging	Het
Ccdc150	G	A	1: 54,339,647 (GRCm39)		probably null	Het
Clca4c-ps	A	T	3: 144,585,593 (GRCm39)		noncoding transcript	Het
Clec4a1	T	C	6: 122,907,680 (GRCm39)	S123P	probably damaging	Het
Col6a4	T	C	9: 105,940,093 (GRCm39)	Y1279C	probably damaging	Het
Cox8c	T	A	12: 102,865,626 (GRCm39)	M1K	probably null	Het
Crat	G	T	2: 30,295,493 (GRCm39)	S370Y	probably damaging	Het
Cts7	A	T	13: 61,503,414 (GRCm39)	D183E	probably benign	Het
Cyp1a2	C	A	9: 57,589,678 (GRCm39)	W45C	probably damaging	Het
Eml5	T	A	12: 98,829,539 (GRCm39)	I492L	probably benign	Het
Fbxl4	T	G	4: 22,422,766 (GRCm39)	L456R	probably damaging	Het
Flt1	G	T	5: 147,620,699 (GRCm39)	H148Q	probably benign	Het
Galnt3	T	C	2: 65,914,606 (GRCm39)	M604V	probably benign	Het
Gatb	T	C	3: 85,518,731 (GRCm39)	V279A	probably damaging	Het
Heatr1	C	A	13: 12,444,680 (GRCm39)	H1543Q	probably benign	Het
Ighg2b	C	T	12: 113,271,305 (GRCm39)	V83I	unknown	Het
Jcad	A	G	18: 4,675,514 (GRCm39)	Q1092R	probably benign	Het
Kirrel3	A	G	9: 34,927,764 (GRCm39)	E6G	probably damaging	Het
Klhl22	A	G	16: 17,610,575 (GRCm39)	S609G	probably benign	Het
Kntc1	A	G	5: 123,904,021 (GRCm39)	Y346C	probably damaging	Het
Maneal	T	C	4: 124,752,948 (GRCm39)	D233G	probably benign	Het
Mcm3ap	T	C	10: 76,306,951 (GRCm39)	S355P	probably benign	Het
Mtus2	C	T	5: 148,240,286 (GRCm39)		probably benign	Het
Muc4	A	G	16: 32,575,383 (GRCm39)	T1380A	probably benign	Het
Nedd4	T	A	9: 72,644,216 (GRCm39)	M661K	possibly damaging	Het
Nomo1	T	C	7: 45,732,651 (GRCm39)		probably benign	Het
Ntmt2	A	G	1: 163,544,689 (GRCm39)	I98T	probably benign	Het
Ntsr2	T	A	12: 16,706,775 (GRCm39)	W268R	probably benign	Het
Nup188	A	C	2: 30,229,862 (GRCm39)	Q1360P	possibly damaging	Het
Or2c1	A	T	16: 3,657,641 (GRCm39)	Q268L	probably damaging	Het
Pabpc1	A	T	15: 36,599,519 (GRCm39)	V392E	probably benign	Het
Pcdhb11	C	A	18: 37,556,565 (GRCm39)	R632S	probably damaging	Het
Phf11	A	G	14: 59,488,578 (GRCm39)	V73A	probably benign	Het
Pnpla6	T	A	8: 3,567,619 (GRCm39)	M87K	probably damaging	Het
Prkd1	C	T	12: 50,413,162 (GRCm39)	G670R	probably damaging	Het
Raf1	G	A	6: 115,653,530 (GRCm39)		probably benign	Het
Rapgef2	T	A	3: 78,999,116 (GRCm39)		probably null	Het
Rnf215	A	T	11: 4,086,615 (GRCm39)	H164L	probably damaging	Het
Slc24a3	T	C	2: 145,086,947 (GRCm39)	V19A	probably benign	Het
Tbc1d16	A	T	11: 119,047,533 (GRCm39)	V396E	probably benign	Het
Tecpr1	T	C	5: 144,134,806 (GRCm39)		probably benign	Het
Thap12	T	A	7: 98,365,706 (GRCm39)	Y625N	possibly damaging	Het
Tshz2	A	T	2: 169,726,603 (GRCm39)	M400L	probably damaging	Het
Ttc28	A	G	5: 111,372,101 (GRCm39)	Y850C	possibly damaging	Het
Ugt1a7c	A	G	1: 88,022,856 (GRCm39)	D5G	probably benign	Het
Vmn2r10	C	T	5: 109,143,543 (GRCm39)	M802I	probably damaging	Het
Washc4	T	C	10: 83,391,973 (GRCm39)	Y220H	probably damaging	Het
Zfhx3	T	A	8: 109,673,825 (GRCm39)	M1625K	probably damaging	Het
Zfp677	T	A	17: 21,617,169 (GRCm39)	N75K	probably damaging	Het
Zzz3	T	C	3: 152,134,007 (GRCm39)	V355A	probably benign	Het

Other mutations in Or6k6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03126:Or6k6	APN	1	173,945,276 (GRCm39)	missense	probably benign	0.07
R0200:Or6k6	UTSW	1	173,945,078 (GRCm39)	missense	probably benign	0.00
R1292:Or6k6	UTSW	1	173,945,420 (GRCm39)	missense	probably benign	0.16
R1966:Or6k6	UTSW	1	173,944,817 (GRCm39)	nonsense	probably null
R2860:Or6k6	UTSW	1	173,945,298 (GRCm39)	missense	probably damaging	1.00
R2861:Or6k6	UTSW	1	173,945,298 (GRCm39)	missense	probably damaging	1.00
R2862:Or6k6	UTSW	1	173,945,298 (GRCm39)	missense	probably damaging	1.00
R4492:Or6k6	UTSW	1	173,944,770 (GRCm39)	missense	probably benign	0.01
R4594:Or6k6	UTSW	1	173,944,886 (GRCm39)	missense	probably damaging	0.96
R4670:Or6k6	UTSW	1	173,945,427 (GRCm39)	missense	probably benign	0.04
R4703:Or6k6	UTSW	1	173,944,964 (GRCm39)	missense	possibly damaging	0.52
R6385:Or6k6	UTSW	1	173,944,862 (GRCm39)	missense	probably damaging	1.00
R7085:Or6k6	UTSW	1	173,945,226 (GRCm39)	missense	probably damaging	1.00
R7426:Or6k6	UTSW	1	173,944,753 (GRCm39)	missense	probably benign	0.00
R7708:Or6k6	UTSW	1	173,945,300 (GRCm39)	missense	probably damaging	0.99
R7780:Or6k6	UTSW	1	173,945,115 (GRCm39)	missense	probably benign	0.02
R9308:Or6k6	UTSW	1	173,945,501 (GRCm39)	missense	probably benign	0.00
Z1088:Or6k6	UTSW	1	173,944,881 (GRCm39)	missense	probably benign	0.38

Posted On

2014-05-07