Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01973:Zfp677'

182602

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp677

Ensembl Gene

ENSMUSG00000062743

Gene Name

zinc finger protein 677

Synonyms

A830058L05Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

IGL01973

Quality Score

Status

Chromosome

Chromosomal Location

21604010-21619527 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 21617169 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 75 (N75K)

Ref Sequence

ENSEMBL: ENSMUSP00000125295 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000056107] [ENSMUST00000162659]

AlphaFold

Q6PEP4

Predicted Effect

probably damaging
Transcript: ENSMUST00000056107
AA Change: N75K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000052667
Gene: ENSMUSG00000062743
AA Change: N75K

Domain	Start	End	E-Value	Type
KRAB	13	75	1.11e-21	SMART
ZnF_C2H2	185	207	2.95e-3	SMART
ZnF_C2H2	213	235	3.95e-4	SMART
ZnF_C2H2	241	263	2.09e-3	SMART
ZnF_C2H2	269	291	6.42e-4	SMART
ZnF_C2H2	297	319	5.5e-3	SMART
ZnF_C2H2	325	347	1.98e-4	SMART
ZnF_C2H2	353	375	1.98e-4	SMART
ZnF_C2H2	381	403	1.47e-3	SMART
ZnF_C2H2	409	431	1.28e-3	SMART
ZnF_C2H2	437	459	3.95e-4	SMART
ZnF_C2H2	465	487	1.04e-3	SMART
ZnF_C2H2	493	515	8.47e-4	SMART
ZnF_C2H2	521	543	7.49e-5	SMART
ZnF_C2H2	549	571	1.18e-2	SMART
ZnF_C2H2	577	599	6.08e-5	SMART
ZnF_C2H2	610	632	4.17e-3	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000162659
AA Change: N75K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000125295
Gene: ENSMUSG00000062743
AA Change: N75K

Domain	Start	End	E-Value	Type
KRAB	13	75	1.11e-21	SMART
Pfam:zf-H2C2_2	118	140	2.9e-5	PFAM
ZnF_C2H2	185	207	2.95e-3	SMART
ZnF_C2H2	213	235	3.95e-4	SMART
ZnF_C2H2	241	263	2.09e-3	SMART
ZnF_C2H2	269	291	6.42e-4	SMART
ZnF_C2H2	297	319	5.5e-3	SMART
ZnF_C2H2	325	347	1.98e-4	SMART
ZnF_C2H2	353	375	1.98e-4	SMART
ZnF_C2H2	381	403	1.47e-3	SMART
ZnF_C2H2	409	431	1.28e-3	SMART
ZnF_C2H2	437	459	3.95e-4	SMART
ZnF_C2H2	465	487	1.04e-3	SMART
ZnF_C2H2	493	515	8.47e-4	SMART
ZnF_C2H2	521	543	7.49e-5	SMART
ZnF_C2H2	549	571	1.18e-2	SMART
ZnF_C2H2	577	599	6.08e-5	SMART
ZnF_C2H2	610	632	4.17e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000232365

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410004P03Rik	A	G	12: 17,061,172 (GRCm39)	W59R	probably damaging	Het
Adam17	C	T	12: 21,399,944 (GRCm39)	R154K	probably damaging	Het
Ajm1	G	T	2: 25,469,584 (GRCm39)	S109*	probably null	Het
Atp9b	A	T	18: 80,801,518 (GRCm39)	F791I	probably benign	Het
Atr	T	G	9: 95,753,727 (GRCm39)	S776R	probably damaging	Het
AW554918	A	T	18: 25,553,056 (GRCm39)	T487S	probably damaging	Het
Bckdhb	T	A	9: 83,873,789 (GRCm39)	F217Y	probably benign	Het
Cacna1i	G	A	15: 80,266,234 (GRCm39)	A1574T	probably damaging	Het
Ccdc150	G	A	1: 54,339,647 (GRCm39)		probably null	Het
Clca4c-ps	A	T	3: 144,585,593 (GRCm39)		noncoding transcript	Het
Clec4a1	T	C	6: 122,907,680 (GRCm39)	S123P	probably damaging	Het
Col6a4	T	C	9: 105,940,093 (GRCm39)	Y1279C	probably damaging	Het
Cox8c	T	A	12: 102,865,626 (GRCm39)	M1K	probably null	Het
Crat	G	T	2: 30,295,493 (GRCm39)	S370Y	probably damaging	Het
Cts7	A	T	13: 61,503,414 (GRCm39)	D183E	probably benign	Het
Cyp1a2	C	A	9: 57,589,678 (GRCm39)	W45C	probably damaging	Het
Eml5	T	A	12: 98,829,539 (GRCm39)	I492L	probably benign	Het
Fbxl4	T	G	4: 22,422,766 (GRCm39)	L456R	probably damaging	Het
Flt1	G	T	5: 147,620,699 (GRCm39)	H148Q	probably benign	Het
Galnt3	T	C	2: 65,914,606 (GRCm39)	M604V	probably benign	Het
Gatb	T	C	3: 85,518,731 (GRCm39)	V279A	probably damaging	Het
Heatr1	C	A	13: 12,444,680 (GRCm39)	H1543Q	probably benign	Het
Ighg2b	C	T	12: 113,271,305 (GRCm39)	V83I	unknown	Het
Jcad	A	G	18: 4,675,514 (GRCm39)	Q1092R	probably benign	Het
Kirrel3	A	G	9: 34,927,764 (GRCm39)	E6G	probably damaging	Het
Klhl22	A	G	16: 17,610,575 (GRCm39)	S609G	probably benign	Het
Kntc1	A	G	5: 123,904,021 (GRCm39)	Y346C	probably damaging	Het
Maneal	T	C	4: 124,752,948 (GRCm39)	D233G	probably benign	Het
Mcm3ap	T	C	10: 76,306,951 (GRCm39)	S355P	probably benign	Het
Mtus2	C	T	5: 148,240,286 (GRCm39)		probably benign	Het
Muc4	A	G	16: 32,575,383 (GRCm39)	T1380A	probably benign	Het
Nedd4	T	A	9: 72,644,216 (GRCm39)	M661K	possibly damaging	Het
Nomo1	T	C	7: 45,732,651 (GRCm39)		probably benign	Het
Ntmt2	A	G	1: 163,544,689 (GRCm39)	I98T	probably benign	Het
Ntsr2	T	A	12: 16,706,775 (GRCm39)	W268R	probably benign	Het
Nup188	A	C	2: 30,229,862 (GRCm39)	Q1360P	possibly damaging	Het
Or2c1	A	T	16: 3,657,641 (GRCm39)	Q268L	probably damaging	Het
Or6k6	A	G	1: 173,945,099 (GRCm39)	F161S	probably damaging	Het
Pabpc1	A	T	15: 36,599,519 (GRCm39)	V392E	probably benign	Het
Pcdhb11	C	A	18: 37,556,565 (GRCm39)	R632S	probably damaging	Het
Phf11	A	G	14: 59,488,578 (GRCm39)	V73A	probably benign	Het
Pnpla6	T	A	8: 3,567,619 (GRCm39)	M87K	probably damaging	Het
Prkd1	C	T	12: 50,413,162 (GRCm39)	G670R	probably damaging	Het
Raf1	G	A	6: 115,653,530 (GRCm39)		probably benign	Het
Rapgef2	T	A	3: 78,999,116 (GRCm39)		probably null	Het
Rnf215	A	T	11: 4,086,615 (GRCm39)	H164L	probably damaging	Het
Slc24a3	T	C	2: 145,086,947 (GRCm39)	V19A	probably benign	Het
Tbc1d16	A	T	11: 119,047,533 (GRCm39)	V396E	probably benign	Het
Tecpr1	T	C	5: 144,134,806 (GRCm39)		probably benign	Het
Thap12	T	A	7: 98,365,706 (GRCm39)	Y625N	possibly damaging	Het
Tshz2	A	T	2: 169,726,603 (GRCm39)	M400L	probably damaging	Het
Ttc28	A	G	5: 111,372,101 (GRCm39)	Y850C	possibly damaging	Het
Ugt1a7c	A	G	1: 88,022,856 (GRCm39)	D5G	probably benign	Het
Vmn2r10	C	T	5: 109,143,543 (GRCm39)	M802I	probably damaging	Het
Washc4	T	C	10: 83,391,973 (GRCm39)	Y220H	probably damaging	Het
Zfhx3	T	A	8: 109,673,825 (GRCm39)	M1625K	probably damaging	Het
Zzz3	T	C	3: 152,134,007 (GRCm39)	V355A	probably benign	Het

Other mutations in Zfp677

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00481:Zfp677	APN	17	21,617,930 (GRCm39)	missense	probably benign	0.33
IGL02206:Zfp677	APN	17	21,613,499 (GRCm39)	missense	probably damaging	1.00
IGL03240:Zfp677	APN	17	21,617,135 (GRCm39)	missense	probably damaging	0.99
IGL03409:Zfp677	APN	17	21,617,107 (GRCm39)	missense	probably damaging	1.00
R0622:Zfp677	UTSW	17	21,617,962 (GRCm39)	missense	probably benign	0.04
R0972:Zfp677	UTSW	17	21,618,572 (GRCm39)	missense	probably damaging	1.00
R1519:Zfp677	UTSW	17	21,617,499 (GRCm39)	missense	possibly damaging	0.91
R2155:Zfp677	UTSW	17	21,617,970 (GRCm39)	missense	probably benign	0.01
R2316:Zfp677	UTSW	17	21,617,582 (GRCm39)	missense	probably benign	0.38
R2866:Zfp677	UTSW	17	21,617,518 (GRCm39)	nonsense	probably null
R2989:Zfp677	UTSW	17	21,617,114 (GRCm39)	missense	probably benign	0.11
R3955:Zfp677	UTSW	17	21,618,079 (GRCm39)	missense	possibly damaging	0.95
R4075:Zfp677	UTSW	17	21,618,421 (GRCm39)	missense	probably damaging	1.00
R4134:Zfp677	UTSW	17	21,618,043 (GRCm39)	missense	probably benign	0.01
R4229:Zfp677	UTSW	17	21,618,544 (GRCm39)	missense	probably damaging	1.00
R4729:Zfp677	UTSW	17	21,617,680 (GRCm39)	missense	possibly damaging	0.51
R4843:Zfp677	UTSW	17	21,612,788 (GRCm39)	missense	probably benign	0.23
R5023:Zfp677	UTSW	17	21,618,056 (GRCm39)	missense	probably damaging	1.00
R5316:Zfp677	UTSW	17	21,617,410 (GRCm39)	missense	probably damaging	0.99
R5420:Zfp677	UTSW	17	21,618,175 (GRCm39)	missense	probably damaging	1.00
R5694:Zfp677	UTSW	17	21,618,021 (GRCm39)	missense	probably damaging	0.99
R5837:Zfp677	UTSW	17	21,617,648 (GRCm39)	missense	probably damaging	1.00
R5888:Zfp677	UTSW	17	21,618,520 (GRCm39)	missense	probably damaging	1.00
R6007:Zfp677	UTSW	17	21,617,918 (GRCm39)	missense	probably damaging	1.00
R6119:Zfp677	UTSW	17	21,618,070 (GRCm39)	missense	possibly damaging	0.55
R6190:Zfp677	UTSW	17	21,617,530 (GRCm39)	missense	possibly damaging	0.91
R6518:Zfp677	UTSW	17	21,618,392 (GRCm39)	missense	probably damaging	1.00
R7198:Zfp677	UTSW	17	21,618,679 (GRCm39)	missense	probably damaging	1.00
R7391:Zfp677	UTSW	17	21,618,653 (GRCm39)	missense	possibly damaging	0.56
R7801:Zfp677	UTSW	17	21,618,277 (GRCm39)	missense	probably damaging	1.00
R7808:Zfp677	UTSW	17	21,617,647 (GRCm39)	missense	probably damaging	1.00
R8202:Zfp677	UTSW	17	21,613,535 (GRCm39)	missense	probably damaging	1.00
R8206:Zfp677	UTSW	17	21,612,717 (GRCm39)	splice site	probably null
R8885:Zfp677	UTSW	17	21,618,350 (GRCm39)	missense	probably benign
R8965:Zfp677	UTSW	17	21,617,155 (GRCm39)	missense	probably damaging	1.00
R9062:Zfp677	UTSW	17	21,612,815 (GRCm39)	critical splice donor site	probably null
R9167:Zfp677	UTSW	17	21,613,460 (GRCm39)	missense	probably damaging	1.00
R9371:Zfp677	UTSW	17	21,618,053 (GRCm39)	missense	probably damaging	1.00
R9638:Zfp677	UTSW	17	21,618,056 (GRCm39)	missense	probably damaging	1.00
R9752:Zfp677	UTSW	17	21,618,511 (GRCm39)	missense	probably damaging	1.00
RF003:Zfp677	UTSW	17	21,617,704 (GRCm39)	missense	probably damaging	1.00

Posted On

2014-05-07